TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1991A/mazE6:

update plot	correlation	link to info on gene
Rv1565c/-	(cc=0.5028)	info on Rv1565c/-
Rv3875/esxA	(cc=0.4993)	info on Rv3875/esxA
Rv1583c/-	(cc=0.4939)	info on Rv1583c/-
Rv0489/gpm1	(cc=0.4938)	info on Rv0489/gpm1
Rv2960c/-	(cc=0.4619)	info on Rv2960c/-
Rv1498A/-	(cc=0.4498)	info on Rv1498A/-
Rv2680/-	(cc=0.447)	info on Rv2680/-
Rv2374c/hrcA	(cc=0.445)	info on Rv2374c/hrcA
Rv1561/vapC11	(cc=0.4388)	info on Rv1561/vapC11
Rv1896c/-	(cc=0.4329)	info on Rv1896c/-

Correlation of Rv1991A/mazE6 with Rv1565c/-

Normalized LFCs for Rv1991A/mazE6:
(description and provenance of datasets)

	Rv1991A/mazE6	Rv1565c/-
Fe_supp_jason_reseq	3.195	4.537
low_pH_jason_reseq	0.694	0.156
NO_jason_reseq	-0.541	0.475
B6_jason_reseq	-0.111	0.881
MHCII_jason_reseq	-0.572	0.603
Isoniazid02	0.314	-0.383
Rifampicin4	0.69	-0.523
Ethambutol3	2.83	-0.946
Meropenem3	0.756	0.926
Vancomycin16	0.626	-2.064
Rv2680_day32	0.393	0.413
H37Rv_KO_MarP	-0.744	-6.0
hypoxia_3wks	-0.486	-0.885
hypoxia_6wks	-0.839	-0.727
glycerol	0.709	-0.168
cholesterol	-0.159	-0.398
AJ	-1.044	-0.637
Bibs02	-0.823	-0.319
Bibs02c	-0.112	-0.365
BL6	1.907	0.351
BL6a	0.839	0.555
BXD01	0.506	0.365
BXD010	1.024	0.0
BXD011	1.548	0.759
BXD03	0.831	0.0
BXD04	0.063	0.49
BXD05	0.57	0.533
BXD06	0.82	-0.111
BXD07	0.434	0.0
BXD08	0.856	0.103
BXD09	0.822	0.109
CAST	-0.859	-0.632
CCcont	1.741	2.714
DS01	1.16	-0.648
DS02	-1.161	-0.597
DS04	1.015	1.244
DS0c	-0.976	-0.596
GP01	0.925	-0.271
GP02	0.511	-0.228
GP0c	2.692	-0.108
NOD	1.103	-0.392
NZO	-0.744	-0.548
PWK	0.196	-0.539
H37Rv_KO_CtpC	0.998	0.968
H37Rv_KO_CtpD	1.213	0.355
H37Rv_KO_Rv1272	-0.424	1.542
H37Rv_KO_SugABC	1.602	0.995
H37Rv_KO_MbtN	0.965	1.407
Trans05	1.43	0.195
macrophage_unactivated	-1.846	-0.83
IL1	0.0	-1.391
Rapamycin	0.227	-1.439
Tcell	-0.43	-0.554
GMCSF	0.259	0.0
IFNab	-1.031	-0.248
IFNg	0.0	0.208
IFNg_GMCSF1	0.732	-0.258
Rv1432_day32	0.0	-1.374
Rv1565c_day32	0.0	0.0
secA2_input	-2.195	-3.58
delta_Rv3594	0.895	1.184
delta_Rv3717	0.429	1.019
delta_Rv3811	0.617	0.546
delta_Rv0954	2.719	-0.389
PonA1	-1.829	-3.057
EccD1_KO	0.483	-0.224
EspI_KO	-0.81	-0.023
PE35_KO	-0.23	-1.718
PPE68_KO	2.24	-0.275
glycerol2	1.09	0.369
lignocerate	0.235	0.462
oleate	-1.517	0.0
phosphatidylcholine	0.508	0.193
acetate	1.774	1.273
glucAc	1.515	0.877
Rv0950ko	0.072	-2.741
Rv1096ko	-0.793	-2.379
Rv3684ko	-0.327	-0.043
delta_otsA_trehalose	0.369	-0.479