TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1944c/-:

update plot	correlation	link to info on gene
Rv3410c/guaB3	(cc=0.6104)	info on Rv3410c/guaB3
Rv1215c/-	(cc=0.525)	info on Rv1215c/-
Rv1962A/vapB35	(cc=0.504)	info on Rv1962A/vapB35
Rv1697/-	(cc=0.5007)	info on Rv1697/-
Rv1785c/cyp143	(cc=0.4725)	info on Rv1785c/cyp143
Rv1552/frdA	(cc=0.4636)	info on Rv1552/frdA
Rv0988/-	(cc=0.4541)	info on Rv0988/-
Rv0013/trpG	(cc=0.4481)	info on Rv0013/trpG
Rv3665c/dppB	(cc=0.4409)	info on Rv3665c/dppB
Rv2677c/hemY	(cc=0.4353)	info on Rv2677c/hemY

Correlation of Rv1944c/- with Rv2677c/hemY

Normalized LFCs for Rv1944c/-:
(description and provenance of datasets)

	Rv1944c/-	Rv2677c/hemY
Fe_supp_jason_reseq	-0.614	-3.105
low_pH_jason_reseq	2.561	-0.363
NO_jason_reseq	-0.788	-0.89
B6_jason_reseq	-0.807	-2.335
MHCII_jason_reseq	-1.64	-2.056
Isoniazid02	3.462	5.986
Rifampicin4	0.173	-0.374
Ethambutol3	3.199	1.475
Meropenem3	0.097	-0.55
Vancomycin16	0.17	-1.218
Rv2680_day32	-0.039	-0.289
H37Rv_KO_MarP	0.49	0.611
hypoxia_3wks	-0.522	-1.005
hypoxia_6wks	0.0	-1.161
glycerol	-0.614	-0.856
cholesterol	0.946	-0.105
AJ	-0.97	-0.983
Bibs02	0.413	-0.592
Bibs02c	-0.67	0.141
BL6	0.477	-0.53
BL6a	0.044	0.26
BXD01	0.734	0.248
BXD010	0.605	0.168
BXD011	0.323	-0.54
BXD03	0.133	0.258
BXD04	-0.627	0.162
BXD05	1.216	-0.201
BXD06	0.314	0.469
BXD07	0.549	0.182
BXD08	0.925	0.467
BXD09	0.196	0.69
CAST	0.367	-0.976
CCcont	0.694	-0.633
DS01	0.282	0.31
DS02	0.532	-0.922
DS04	0.252	-0.141
DS0c	1.279	0.413
GP01	0.843	0.644
GP02	2.041	-0.269
GP0c	1.277	0.581
NOD	0.944	-0.727
NZO	-0.517	-0.465
PWK	1.269	-0.831
H37Rv_KO_CtpC	1.205	2.143
H37Rv_KO_CtpD	0.344	-0.41
H37Rv_KO_Rv1272	1.093	1.07
H37Rv_KO_SugABC	0.768	-0.42
H37Rv_KO_MbtN	0.08	-0.154
Trans05	-0.126	-0.305
macrophage_unactivated	0.9	2.326
IL1	-0.89	0.658
Rapamycin	-0.387	-0.252
Tcell	1.388	0.495
GMCSF	-0.42	-0.217
IFNab	0.514	1.255
IFNg	-0.249	-1.253
IFNg_GMCSF1	0.273	0.0
Rv1432_day32	1.073	0.0
Rv1565c_day32	0.444	0.673
secA2_input	0.402	0.568
delta_Rv3594	-0.26	0.142
delta_Rv3717	0.191	0.0
delta_Rv3811	-0.327	0.617
delta_Rv0954	0.213	1.096
PonA1	0.454	0.712
EccD1_KO	0.342	-0.559
EspI_KO	0.328	-0.234
PE35_KO	0.732	0.0
PPE68_KO	-0.038	-0.544
glycerol2	0.548	-0.689
lignocerate	0.258	-1.34
oleate	0.525	0.0
phosphatidylcholine	0.978	-0.753
acetate	-0.279	-1.716
glucAc	-0.194	-2.243
Rv0950ko	-1.933	-0.235
Rv1096ko	-0.799	0.832
Rv3684ko	-2.512	1.66
delta_otsA_trehalose	-1.08	-0.336