TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1929c/-:

update plot	correlation	link to info on gene
Rv1780/-	(cc=0.4605)	info on Rv1780/-
Rv2266/cyp124	(cc=0.3777)	info on Rv2266/cyp124
Rv0644c/mmaA2	(cc=0.3745)	info on Rv0644c/mmaA2
Rv3181c/-	(cc=0.3703)	info on Rv3181c/-
Rv1554/frdC	(cc=0.3601)	info on Rv1554/frdC
Rv1552/frdA	(cc=0.3579)	info on Rv1552/frdA
Rv1058/fadD14	(cc=0.355)	info on Rv1058/fadD14
Rv0088/-	(cc=0.3404)	info on Rv0088/-
Rv2173/idsA2	(cc=0.3362)	info on Rv2173/idsA2
Rv3112/moaD1	(cc=0.3346)	info on Rv3112/moaD1

Correlation of Rv1929c/- with Rv1058/fadD14

Normalized LFCs for Rv1929c/-:
(description and provenance of datasets)

	Rv1929c/-	Rv1058/fadD14
Fe_supp_jason_reseq	-1.299	0.845
low_pH_jason_reseq	0.142	2.618
NO_jason_reseq	-0.845	-0.323
B6_jason_reseq	-0.601	-1.356
MHCII_jason_reseq	0.576	-0.435
Isoniazid02	0.167	-0.194
Rifampicin4	-0.054	-0.116
Ethambutol3	0.392	0.148
Meropenem3	-0.073	0.406
Vancomycin16	0.106	-0.544
Rv2680_day32	1.782	1.435
H37Rv_KO_MarP	0.512	-0.653
hypoxia_3wks	1.747	1.535
hypoxia_6wks	2.464	3.247
glycerol	0.521	1.09
cholesterol	0.898	1.217
AJ	0.165	1.03
Bibs02	0.216	0.262
Bibs02c	-0.182	1.816
BL6	-0.806	3.092
BL6a	0.178	2.987
BXD01	1.214	3.11
BXD010	0.441	2.481
BXD011	1.22	2.298
BXD03	0.775	1.948
BXD04	-0.18	2.976
BXD05	-0.742	2.087
BXD06	0.812	2.618
BXD07	1.003	2.642
BXD08	-0.086	2.699
BXD09	0.98	2.228
CAST	-0.148	-0.222
CCcont	-1.246	2.164
DS01	0.098	0.14
DS02	-0.29	0.83
DS04	-0.97	0.975
DS0c	0.195	0.963
GP01	1.263	2.962
GP02	0.686	2.733
GP0c	-0.027	2.85
NOD	0.225	0.997
NZO	0.397	0.675
PWK	-0.02	0.281
H37Rv_KO_CtpC	-0.581	0.877
H37Rv_KO_CtpD	0.064	1.601
H37Rv_KO_Rv1272	0.598	2.677
H37Rv_KO_SugABC	1.188	3.098
H37Rv_KO_MbtN	-1.162	1.92
Trans05	1.007	2.268
macrophage_unactivated	1.228	-0.123
IL1	-0.988	-0.116
Rapamycin	0.436	-0.371
Tcell	1.193	0.394
GMCSF	-0.639	-1.714
IFNab	-1.007	0.284
IFNg	-0.647	-2.913
IFNg_GMCSF1	-1.48	-2.599
Rv1432_day32	-0.279	2.88
Rv1565c_day32	0.013	1.579
secA2_input	-1.191	1.374
delta_Rv3594	0.835	1.779
delta_Rv3717	-0.048	2.157
delta_Rv3811	0.754	1.756
delta_Rv0954	-0.672	0.049
PonA1	-1.111	-0.851
EccD1_KO	-0.418	-0.046
EspI_KO	-0.508	-0.365
PE35_KO	0.54	-0.98
PPE68_KO	1.952	-0.41
glycerol2	-0.497	1.219
lignocerate	4.317	1.649
oleate	-0.459	-1.157
phosphatidylcholine	-0.528	0.655
acetate	-1.503	0.712
glucAc	-1.255	0.682
Rv0950ko	-0.323	-0.648
Rv1096ko	-2.337	0.1
Rv3684ko	-2.538	-0.262
delta_otsA_trehalose	-0.719	-0.009