TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1797/eccE5:

update plot	correlation	link to info on gene
Rv1783/eccC5	(cc=0.9797)	info on Rv1783/eccC5
Rv1782/eccB5	(cc=0.9136)	info on Rv1782/eccB5
Rv1794/-	(cc=0.8868)	info on Rv1794/-
Rv1796/mycP5	(cc=0.8793)	info on Rv1796/mycP5
Rv1795/eccD5	(cc=0.8763)	info on Rv1795/eccD5
Rv0537c/-	(cc=0.4633)	info on Rv0537c/-
Rv1267c/embR	(cc=0.4281)	info on Rv1267c/embR
Rv1063c/-	(cc=0.4231)	info on Rv1063c/-
Rv0538/-	(cc=0.4035)	info on Rv0538/-
Rv1532c/-	(cc=0.3928)	info on Rv1532c/-

Correlation of Rv1797/eccE5 with Rv1795/eccD5

Normalized LFCs for Rv1797/eccE5:
(description and provenance of datasets)

	Rv1797/eccE5	Rv1795/eccD5
Fe_supp_jason_reseq	0.218	0.415
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	0.0	0.0
Rifampicin4	0.0	0.0
Ethambutol3	0.0	0.0
Meropenem3	0.0	0.0
Vancomycin16	0.0	0.0
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	6.0	5.012
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	0.0	4.046
cholesterol	0.145	1.325
AJ	0.0	0.0
Bibs02	0.0	0.0
Bibs02c	0.0	1.028
BL6	0.0	0.0
BL6a	0.0	0.377
BXD01	0.0	0.0
BXD010	0.0	0.0
BXD011	0.0	0.0
BXD03	0.0	0.0
BXD04	0.0	0.0
BXD05	0.0	0.0
BXD06	0.0	0.0
BXD07	0.0	0.0
BXD08	0.0	0.0
BXD09	0.0	0.0
CAST	0.0	0.23
CCcont	0.149	0.149
DS01	0.0	0.0
DS02	0.0	0.0
DS04	0.0	0.0
DS0c	0.0	0.0
GP01	3.42	4.073
GP02	3.65	4.279
GP0c	4.084	5.395
NOD	0.0	0.0
NZO	0.0	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	0.0	0.0
H37Rv_KO_CtpD	0.0	0.0
H37Rv_KO_Rv1272	0.0	0.0
H37Rv_KO_SugABC	0.0	0.0
H37Rv_KO_MbtN	0.0	0.0
Trans05	0.0	0.0
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	0.0	0.216
delta_Rv3594	0.0	0.0
delta_Rv3717	0.331	0.853
delta_Rv3811	0.0	0.0
delta_Rv0954	1.196	2.536
PonA1	0.0	0.0
EccD1_KO	0.0	0.0
EspI_KO	-0.394	0.0
PE35_KO	0.0	0.767
PPE68_KO	-0.442	0.442
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	0.0	0.38
Rv1096ko	0.38	0.38
Rv3684ko	-0.452	0.0
delta_otsA_trehalose	0.0	0.0