TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1715/fadB3:

update plot	correlation	link to info on gene
Rv1681/moeX	(cc=0.4538)	info on Rv1681/moeX
Rv1078/pra	(cc=0.4386)	info on Rv1078/pra
Rv2785c/rpsO	(cc=0.4229)	info on Rv2785c/rpsO
Rv0092/ctpA	(cc=0.4172)	info on Rv0092/ctpA
Rv0671/lpqP	(cc=0.4077)	info on Rv0671/lpqP
Rv1457c/-	(cc=0.3976)	info on Rv1457c/-
Rv2202c/adoK	(cc=0.3849)	info on Rv2202c/adoK
Rv3073c/-	(cc=0.3827)	info on Rv3073c/-
Rv1458c/-	(cc=0.3827)	info on Rv1458c/-
Rv3043c/ctaD	(cc=0.3676)	info on Rv3043c/ctaD

Correlation of Rv1715/fadB3 with Rv2202c/adoK

Normalized LFCs for Rv1715/fadB3:
(description and provenance of datasets)

	Rv1715/fadB3	Rv2202c/adoK
Fe_supp_jason_reseq	0.655	0.0
low_pH_jason_reseq	0.842	0.231
NO_jason_reseq	-0.108	0.0
B6_jason_reseq	0.994	0.0
MHCII_jason_reseq	-0.406	0.0
Isoniazid02	0.141	0.0
Rifampicin4	0.0	0.0
Ethambutol3	3.89	0.0
Meropenem3	0.604	0.0
Vancomycin16	0.257	0.0
Rv2680_day32	-0.131	0.0
H37Rv_KO_MarP	0.0	0.0
hypoxia_3wks	-0.439	0.0
hypoxia_6wks	0.347	0.0
glycerol	0.233	0.0
cholesterol	-0.401	0.0
AJ	-1.856	0.0
Bibs02	-0.138	0.0
Bibs02c	2.402	0.0
BL6	-1.782	0.0
BL6a	1.362	0.0
BXD01	-0.28	0.0
BXD010	-0.574	0.0
BXD011	-0.776	0.0
BXD03	-1.397	0.0
BXD04	0.168	0.0
BXD05	-0.708	0.0
BXD06	-0.412	0.0
BXD07	-0.257	0.138
BXD08	-0.81	0.0
BXD09	0.191	0.14
CAST	0.41	0.0
CCcont	-0.785	0.0
DS01	1.095	0.0
DS02	-0.468	0.0
DS04	-2.135	0.0
DS0c	0.431	0.0
GP01	1.317	0.0
GP02	-0.204	0.0
GP0c	0.926	0.0
NOD	-0.29	0.0
NZO	-2.494	0.0
PWK	-1.032	0.0
H37Rv_KO_CtpC	-0.854	0.0
H37Rv_KO_CtpD	1.231	0.0
H37Rv_KO_Rv1272	-0.742	0.0
H37Rv_KO_SugABC	-0.184	0.0
H37Rv_KO_MbtN	1.183	0.0
Trans05	-0.168	0.0
macrophage_unactivated	-0.328	0.0
IL1	0.288	0.0
Rapamycin	0.927	0.0
Tcell	0.417	0.0
GMCSF	0.65	0.0
IFNab	-1.288	0.0
IFNg	-0.906	0.0
IFNg_GMCSF1	0.402	0.0
Rv1432_day32	-0.391	0.0
Rv1565c_day32	-1.779	0.0
secA2_input	2.203	1.675
delta_Rv3594	0.13	0.0
delta_Rv3717	0.107	0.0
delta_Rv3811	0.358	0.0
delta_Rv0954	-0.375	0.0
PonA1	-0.274	0.0
EccD1_KO	-1.322	0.0
EspI_KO	-0.596	0.0
PE35_KO	-1.327	0.0
PPE68_KO	-1.811	0.0
glycerol2	-1.058	0.0
lignocerate	-0.865	0.0
oleate	-0.665	0.0
phosphatidylcholine	-0.606	0.0
acetate	-0.547	0.0
glucAc	-1.409	0.0
Rv0950ko	-1.022	-0.793
Rv1096ko	-1.565	-0.793
Rv3684ko	-2.561	-0.861
delta_otsA_trehalose	-0.465	0.0