TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1567c/-:

update plot	correlation	link to info on gene
Rv2724c/fadE20	(cc=0.5234)	info on Rv2724c/fadE20
Rv1500/-	(cc=0.494)	info on Rv1500/-
Rv2355/-	(cc=0.4863)	info on Rv2355/-
Rv0796/-	(cc=0.4834)	info on Rv0796/-
Rv2735c/-	(cc=0.4828)	info on Rv2735c/-
Rv1724c/-	(cc=0.4776)	info on Rv1724c/-
Rv0989c/grcC2	(cc=0.4772)	info on Rv0989c/grcC2
Rv3854c/ethA	(cc=0.4762)	info on Rv3854c/ethA
Rv3796/-	(cc=0.4757)	info on Rv3796/-
Rv0924c/mntH	(cc=0.4742)	info on Rv0924c/mntH

Correlation of Rv1567c/- with Rv2724c/fadE20

Normalized LFCs for Rv1567c/-:
(description and provenance of datasets)

	Rv1567c/-	Rv2724c/fadE20
Fe_supp_jason_reseq	0.767	-0.052
low_pH_jason_reseq	-0.627	-0.571
NO_jason_reseq	0.57	0.215
B6_jason_reseq	1.235	0.553
MHCII_jason_reseq	1.475	-0.271
Isoniazid02	0.17	-0.431
Rifampicin4	0.008	0.317
Ethambutol3	0.027	-1.149
Meropenem3	-0.162	-1.343
Vancomycin16	-1.098	-0.69
Rv2680_day32	0.08	0.171
H37Rv_KO_MarP	-1.002	0.282
hypoxia_3wks	0.0	0.315
hypoxia_6wks	0.516	0.808
glycerol	-0.922	-0.24
cholesterol	0.833	-0.028
AJ	0.397	0.308
Bibs02	1.429	0.25
Bibs02c	1.132	0.467
BL6	0.8	0.089
BL6a	1.179	0.288
BXD01	0.751	0.361
BXD010	0.698	0.311
BXD011	0.41	0.141
BXD03	0.526	0.115
BXD04	0.66	0.583
BXD05	1.028	0.583
BXD06	0.772	0.171
BXD07	0.823	0.214
BXD08	0.557	0.082
BXD09	0.901	-0.129
CAST	0.484	0.639
CCcont	0.438	-0.202
DS01	0.932	0.462
DS02	0.993	0.451
DS04	0.004	0.448
DS0c	0.919	0.432
GP01	0.938	0.342
GP02	1.096	0.353
GP0c	0.623	-0.258
NOD	1.23	0.801
NZO	0.184	0.397
PWK	0.698	0.76
H37Rv_KO_CtpC	0.358	0.145
H37Rv_KO_CtpD	1.02	0.258
H37Rv_KO_Rv1272	0.468	-0.206
H37Rv_KO_SugABC	0.84	0.621
H37Rv_KO_MbtN	0.264	-0.248
Trans05	0.562	0.185
macrophage_unactivated	0.395	-0.398
IL1	-0.199	-0.288
Rapamycin	-0.123	-0.712
Tcell	-0.248	-0.482
GMCSF	-0.338	-0.94
IFNab	0.354	-0.209
IFNg	0.091	-0.58
IFNg_GMCSF1	0.955	-0.352
Rv1432_day32	-0.413	-0.039
Rv1565c_day32	0.531	0.319
secA2_input	-0.661	-0.579
delta_Rv3594	0.439	0.944
delta_Rv3717	0.857	0.439
delta_Rv3811	0.225	0.473
delta_Rv0954	1.813	0.731
PonA1	0.395	0.568
EccD1_KO	-0.559	-0.306
EspI_KO	-0.987	0.305
PE35_KO	-0.263	-0.207
PPE68_KO	-0.717	-0.566
glycerol2	-0.09	-0.163
lignocerate	0.356	-0.402
oleate	-0.679	0.381
phosphatidylcholine	-0.211	-0.3
acetate	-0.121	-0.816
glucAc	-0.334	-0.573
Rv0950ko	0.528	-0.054
Rv1096ko	-0.477	-0.739
Rv3684ko	0.075	0.059
delta_otsA_trehalose	-0.301	-0.182