TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1527c/pks5:

update plot	correlation	link to info on gene
Rv1838c/vapC13	(cc=0.5927)	info on Rv1838c/vapC13
Rv2123/PPE37	(cc=0.534)	info on Rv2123/PPE37
Rv0278c/PE_PGRS3	(cc=0.5279)	info on Rv0278c/PE_PGRS3
Rv0969/ctpV	(cc=0.5033)	info on Rv0969/ctpV
Rv1834/lipZ	(cc=0.5007)	info on Rv1834/lipZ
Rv1760/-	(cc=0.4985)	info on Rv1760/-
Rv2177c/-	(cc=0.4975)	info on Rv2177c/-
Rv1625c/cya	(cc=0.4968)	info on Rv1625c/cya
Rv1263/amiB2	(cc=0.4927)	info on Rv1263/amiB2
Rv2025c/-	(cc=0.4908)	info on Rv2025c/-

Correlation of Rv1527c/pks5 with Rv2177c/-

Normalized LFCs for Rv1527c/pks5:
(description and provenance of datasets)

	Rv1527c/pks5	Rv2177c/-
Fe_supp_jason_reseq	0.175	0.011
low_pH_jason_reseq	-0.587	-1.226
NO_jason_reseq	-0.155	0.302
B6_jason_reseq	0.181	0.386
MHCII_jason_reseq	0.229	-0.305
Isoniazid02	-0.015	-0.054
Rifampicin4	-0.057	1.162
Ethambutol3	0.225	0.672
Meropenem3	0.915	0.639
Vancomycin16	-0.056	0.504
Rv2680_day32	-0.199	-0.169
H37Rv_KO_MarP	0.189	-0.174
hypoxia_3wks	0.159	0.271
hypoxia_6wks	0.294	0.336
glycerol	0.196	-0.312
cholesterol	0.013	-0.143
AJ	0.622	0.948
Bibs02	0.15	-0.38
Bibs02c	0.477	-0.394
BL6	0.251	-0.158
BL6a	0.066	-0.205
BXD01	-0.215	-0.61
BXD010	0.021	-0.632
BXD011	-0.262	-0.555
BXD03	-0.108	-0.386
BXD04	-0.508	-0.057
BXD05	0.022	-0.039
BXD06	-0.39	-0.068
BXD07	-0.036	-0.227
BXD08	0.022	-0.352
BXD09	-0.304	0.067
CAST	-0.12	0.494
CCcont	0.025	-0.651
DS01	0.554	0.417
DS02	0.126	0.384
DS04	0.455	1.362
DS0c	0.325	-0.506
GP01	1.712	1.28
GP02	0.477	0.324
GP0c	0.555	1.16
NOD	0.304	-0.028
NZO	0.314	0.88
PWK	-0.017	0.861
H37Rv_KO_CtpC	0.314	-0.189
H37Rv_KO_CtpD	0.143	-0.601
H37Rv_KO_Rv1272	0.415	0.397
H37Rv_KO_SugABC	0.611	0.481
H37Rv_KO_MbtN	-0.13	-1.489
Trans05	0.289	1.047
macrophage_unactivated	-0.158	-0.887
IL1	-0.074	-0.736
Rapamycin	-0.114	-0.126
Tcell	-0.081	-0.365
GMCSF	0.19	0.29
IFNab	-0.151	-0.538
IFNg	-0.134	-0.997
IFNg_GMCSF1	0.189	-0.352
Rv1432_day32	0.216	0.245
Rv1565c_day32	-0.104	-0.283
secA2_input	0.523	1.116
delta_Rv3594	0.021	-0.433
delta_Rv3717	-0.374	-0.233
delta_Rv3811	0.312	-0.312
delta_Rv0954	-0.172	-0.59
PonA1	0.492	-0.087
EccD1_KO	0.089	-0.253
EspI_KO	0.262	0.225
PE35_KO	0.23	-0.761
PPE68_KO	0.378	-0.646
glycerol2	0.46	-0.017
lignocerate	0.673	-0.029
oleate	0.373	0.301
phosphatidylcholine	0.696	0.283
acetate	0.845	0.735
glucAc	0.441	0.176
Rv0950ko	0.422	-0.19
Rv1096ko	0.311	-0.166
Rv3684ko	0.498	-0.449
delta_otsA_trehalose	0.551	-0.662