TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1215c/-:

update plot	correlation	link to info on gene
Rv1482c/-	(cc=0.6263)	info on Rv1482c/-
Rv0844c/narL	(cc=0.6025)	info on Rv0844c/narL
Rv1616/-	(cc=0.5809)	info on Rv1616/-
Rv3378c/-	(cc=0.5474)	info on Rv3378c/-
Rv1949c/-	(cc=0.5463)	info on Rv1949c/-
Rv2929/-	(cc=0.5324)	info on Rv2929/-
Rv1944c/-	(cc=0.525)	info on Rv1944c/-
Rv1871c/-	(cc=0.5209)	info on Rv1871c/-
Rv2529/-	(cc=0.5143)	info on Rv2529/-
Rv2161c/-	(cc=0.5035)	info on Rv2161c/-

Correlation of Rv1215c/- with Rv1949c/-

Normalized LFCs for Rv1215c/-:
(description and provenance of datasets)

	Rv1215c/-	Rv1949c/-
Fe_supp_jason_reseq	-0.272	0.311
low_pH_jason_reseq	0.11	-0.689
NO_jason_reseq	0.339	0.239
B6_jason_reseq	-0.613	-0.692
MHCII_jason_reseq	-1.388	-0.969
Isoniazid02	0.755	-0.113
Rifampicin4	0.441	-0.011
Ethambutol3	2.03	0.047
Meropenem3	0.919	0.629
Vancomycin16	0.276	-0.377
Rv2680_day32	0.171	0.057
H37Rv_KO_MarP	0.334	0.48
hypoxia_3wks	0.622	0.303
hypoxia_6wks	0.0	-0.547
glycerol	-0.127	-0.888
cholesterol	0.069	0.519
AJ	0.536	-0.044
Bibs02	-0.399	0.258
Bibs02c	-0.488	-0.341
BL6	0.418	-0.195
BL6a	0.141	-0.142
BXD01	0.339	0.438
BXD010	0.527	-0.041
BXD011	1.165	0.194
BXD03	0.172	0.242
BXD04	0.158	0.926
BXD05	0.27	0.283
BXD06	0.515	0.033
BXD07	0.25	0.226
BXD08	0.743	0.742
BXD09	0.53	0.274
CAST	0.509	0.085
CCcont	0.054	-0.573
DS01	0.058	0.074
DS02	0.323	0.041
DS04	0.093	-0.675
DS0c	0.079	-0.402
GP01	0.529	0.819
GP02	1.583	0.762
GP0c	0.077	-0.221
NOD	-0.172	-0.072
NZO	0.98	0.038
PWK	0.117	-0.013
H37Rv_KO_CtpC	0.721	0.887
H37Rv_KO_CtpD	0.5	0.158
H37Rv_KO_Rv1272	0.837	0.568
H37Rv_KO_SugABC	-0.024	0.301
H37Rv_KO_MbtN	0.297	0.92
Trans05	0.601	1.347
macrophage_unactivated	-0.186	0.139
IL1	-0.264	-0.792
Rapamycin	-0.181	-0.344
Tcell	0.14	-0.15
GMCSF	-0.037	0.364
IFNab	0.088	-0.369
IFNg	-0.238	0.024
IFNg_GMCSF1	-0.632	-0.264
Rv1432_day32	1.285	0.068
Rv1565c_day32	0.092	0.019
secA2_input	-0.604	-0.753
delta_Rv3594	-0.194	0.044
delta_Rv3717	-0.932	-0.059
delta_Rv3811	-0.598	-0.123
delta_Rv0954	-0.872	-0.69
PonA1	-0.016	-0.125
EccD1_KO	0.457	0.158
EspI_KO	0.311	-0.08
PE35_KO	0.405	0.099
PPE68_KO	0.253	0.067
glycerol2	-0.031	0.115
lignocerate	-0.054	-0.438
oleate	0.593	0.644
phosphatidylcholine	0.539	0.409
acetate	-0.409	-1.159
glucAc	-0.644	-1.522
Rv0950ko	-0.347	0.075
Rv1096ko	0.042	-0.995
Rv3684ko	-0.331	-0.305
delta_otsA_trehalose	-0.673	-0.338