TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1215c/-:

update plot	correlation	link to info on gene
Rv1482c/-	(cc=0.6263)	info on Rv1482c/-
Rv0844c/narL	(cc=0.6025)	info on Rv0844c/narL
Rv1616/-	(cc=0.5809)	info on Rv1616/-
Rv3378c/-	(cc=0.5474)	info on Rv3378c/-
Rv1949c/-	(cc=0.5463)	info on Rv1949c/-
Rv2929/-	(cc=0.5324)	info on Rv2929/-
Rv1944c/-	(cc=0.525)	info on Rv1944c/-
Rv1871c/-	(cc=0.5209)	info on Rv1871c/-
Rv2529/-	(cc=0.5143)	info on Rv2529/-
Rv2161c/-	(cc=0.5035)	info on Rv2161c/-

Correlation of Rv1215c/- with Rv1871c/-

Normalized LFCs for Rv1215c/-:
(description and provenance of datasets)

	Rv1215c/-	Rv1871c/-
Fe_supp_jason_reseq	-0.272	-0.912
low_pH_jason_reseq	0.11	-0.53
NO_jason_reseq	0.339	0.473
B6_jason_reseq	-0.613	-1.258
MHCII_jason_reseq	-1.388	-1.425
Isoniazid02	0.755	1.439
Rifampicin4	0.441	0.479
Ethambutol3	2.03	0.428
Meropenem3	0.919	0.461
Vancomycin16	0.276	0.456
Rv2680_day32	0.171	-0.682
H37Rv_KO_MarP	0.334	-0.285
hypoxia_3wks	0.622	0.75
hypoxia_6wks	0.0	0.073
glycerol	-0.127	-0.992
cholesterol	0.069	-0.324
AJ	0.536	-0.239
Bibs02	-0.399	-0.36
Bibs02c	-0.488	-1.199
BL6	0.418	-0.055
BL6a	0.141	-0.277
BXD01	0.339	-0.095
BXD010	0.527	0.395
BXD011	1.165	0.603
BXD03	0.172	-0.029
BXD04	0.158	-0.269
BXD05	0.27	0.71
BXD06	0.515	0.057
BXD07	0.25	0.007
BXD08	0.743	0.157
BXD09	0.53	-0.145
CAST	0.509	0.37
CCcont	0.054	-0.471
DS01	0.058	-0.039
DS02	0.323	-0.501
DS04	0.093	-0.177
DS0c	0.079	-0.277
GP01	0.529	1.05
GP02	1.583	0.11
GP0c	0.077	0.703
NOD	-0.172	0.485
NZO	0.98	-0.688
PWK	0.117	-0.604
H37Rv_KO_CtpC	0.721	0.112
H37Rv_KO_CtpD	0.5	0.495
H37Rv_KO_Rv1272	0.837	0.893
H37Rv_KO_SugABC	-0.024	0.349
H37Rv_KO_MbtN	0.297	1.584
Trans05	0.601	0.698
macrophage_unactivated	-0.186	0.625
IL1	-0.264	-0.403
Rapamycin	-0.181	0.476
Tcell	0.14	-0.345
GMCSF	-0.037	0.869
IFNab	0.088	0.686
IFNg	-0.238	-0.168
IFNg_GMCSF1	-0.632	0.292
Rv1432_day32	1.285	-0.485
Rv1565c_day32	0.092	-0.009
secA2_input	-0.604	-0.994
delta_Rv3594	-0.194	-1.137
delta_Rv3717	-0.932	-1.158
delta_Rv3811	-0.598	-0.758
delta_Rv0954	-0.872	-0.908
PonA1	-0.016	-1.138
EccD1_KO	0.457	-0.306
EspI_KO	0.311	0.915
PE35_KO	0.405	-0.184
PPE68_KO	0.253	-0.074
glycerol2	-0.031	0.265
lignocerate	-0.054	-0.578
oleate	0.593	0.698
phosphatidylcholine	0.539	0.37
acetate	-0.409	-0.836
glucAc	-0.644	-1.325
Rv0950ko	-0.347	-0.874
Rv1096ko	0.042	-1.378
Rv3684ko	-0.331	-0.707
delta_otsA_trehalose	-0.673	0.11