TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1074c/fadA3:

update plot	correlation	link to info on gene
Rv3160c/-	(cc=0.5509)	info on Rv3160c/-
Rv1069c/-	(cc=0.5367)	info on Rv1069c/-
Rv1071c/echA9	(cc=0.5258)	info on Rv1071c/echA9
Rv1995/-	(cc=0.5228)	info on Rv1995/-
Rv2395/-	(cc=0.5199)	info on Rv2395/-
Rv3059/cyp136	(cc=0.5138)	info on Rv3059/cyp136
Rv0853c/pdc	(cc=0.5105)	info on Rv0853c/pdc
Rv2007c/fdxA	(cc=0.5105)	info on Rv2007c/fdxA
Rv1852/ureG	(cc=0.5077)	info on Rv1852/ureG
Rv0241c/htdX	(cc=0.5006)	info on Rv0241c/htdX

Correlation of Rv1074c/fadA3 with Rv2395/-

Normalized LFCs for Rv1074c/fadA3:
(description and provenance of datasets)

	Rv1074c/fadA3	Rv2395/-
Fe_supp_jason_reseq	0.156	-0.474
low_pH_jason_reseq	-1.651	-0.663
NO_jason_reseq	-1.131	0.137
B6_jason_reseq	0.294	-0.222
MHCII_jason_reseq	0.55	-0.09
Isoniazid02	0.787	0.975
Rifampicin4	0.709	-0.127
Ethambutol3	2.327	-0.026
Meropenem3	0.417	-0.025
Vancomycin16	0.117	-0.18
Rv2680_day32	-1.003	-0.175
H37Rv_KO_MarP	-0.365	0.186
hypoxia_3wks	-0.578	0.0
hypoxia_6wks	-0.42	-0.048
glycerol	-0.492	-0.43
cholesterol	-0.829	0.014
AJ	-0.23	0.207
Bibs02	-0.372	0.005
Bibs02c	-1.543	0.15
BL6	0.206	-0.177
BL6a	-0.709	-0.208
BXD01	-0.276	-0.095
BXD010	0.07	-0.248
BXD011	-0.377	-0.042
BXD03	-0.348	-0.109
BXD04	-0.428	-0.165
BXD05	-0.118	0.108
BXD06	-0.3	-0.14
BXD07	-0.282	-0.368
BXD08	-0.629	0.066
BXD09	-0.441	-0.345
CAST	0.289	0.312
CCcont	-0.023	-0.526
DS01	-0.313	-0.053
DS02	-0.321	0.049
DS04	-0.021	-0.142
DS0c	0.179	0.262
GP01	-1.025	-0.516
GP02	-0.154	-0.297
GP0c	-1.127	-0.667
NOD	1.271	0.373
NZO	-0.16	-0.139
PWK	0.479	0.482
H37Rv_KO_CtpC	0.144	-0.297
H37Rv_KO_CtpD	-0.442	0.568
H37Rv_KO_Rv1272	0.994	0.314
H37Rv_KO_SugABC	0.225	-0.177
H37Rv_KO_MbtN	-0.354	0.033
Trans05	0.103	-0.228
macrophage_unactivated	0.982	0.372
IL1	0.047	0.237
Rapamycin	0.393	0.107
Tcell	0.0	0.277
GMCSF	0.673	0.586
IFNab	0.284	-0.091
IFNg	0.23	0.358
IFNg_GMCSF1	0.317	0.163
Rv1432_day32	0.237	0.237
Rv1565c_day32	0.088	-0.062
secA2_input	0.564	0.265
delta_Rv3594	0.454	0.187
delta_Rv3717	0.052	-0.031
delta_Rv3811	-0.028	-0.064
delta_Rv0954	1.149	0.623
PonA1	0.083	0.479
EccD1_KO	0.46	0.543
EspI_KO	1.069	-0.16
PE35_KO	1.517	0.158
PPE68_KO	1.072	-0.179
glycerol2	1.118	0.277
lignocerate	1.327	0.369
oleate	0.143	0.17
phosphatidylcholine	1.452	0.542
acetate	0.158	-0.251
glucAc	0.093	-0.006
Rv0950ko	0.582	1.182
Rv1096ko	0.244	0.648
Rv3684ko	0.868	0.403
delta_otsA_trehalose	2.072	1.511