TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0934/pstS1:

update plot	correlation	link to info on gene
Rv0940c/-	(cc=0.6869)	info on Rv0940c/-
Rv3389c/htdY	(cc=0.6347)	info on Rv3389c/htdY
Rv3473c/bpoA	(cc=0.6326)	info on Rv3473c/bpoA
Rv1489A/-	(cc=0.6258)	info on Rv1489A/-
Rv2281/pitB	(cc=0.6159)	info on Rv2281/pitB
Rv1159A/-	(cc=0.5509)	info on Rv1159A/-
Rv1169c/lipX	(cc=0.5252)	info on Rv1169c/lipX
Rv0232/-	(cc=0.524)	info on Rv0232/-
Rv3508/PE_PGRS54	(cc=0.5202)	info on Rv3508/PE_PGRS54
Rv0343/iniC	(cc=0.5202)	info on Rv0343/iniC

Correlation of Rv0934/pstS1 with Rv3389c/htdY

Normalized LFCs for Rv0934/pstS1:
(description and provenance of datasets)

	Rv0934/pstS1	Rv3389c/htdY
Fe_supp_jason_reseq	-0.764	-0.699
low_pH_jason_reseq	-0.391	-0.965
NO_jason_reseq	0.722	-0.396
B6_jason_reseq	-0.065	-1.175
MHCII_jason_reseq	0.128	-1.29
Isoniazid02	-1.689	-1.947
Rifampicin4	0.766	0.577
Ethambutol3	-2.021	-1.544
Meropenem3	-1.711	-1.27
Vancomycin16	-0.52	-1.112
Rv2680_day32	0.066	0.894
H37Rv_KO_MarP	-0.069	0.686
hypoxia_3wks	-0.419	-0.909
hypoxia_6wks	0.175	-0.163
glycerol	0.629	0.158
cholesterol	0.085	-0.35
AJ	0.825	-0.064
Bibs02	-0.389	0.632
Bibs02c	0.33	0.875
BL6	0.977	0.353
BL6a	0.304	0.659
BXD01	0.422	0.085
BXD010	0.584	0.959
BXD011	0.511	-0.158
BXD03	0.348	0.315
BXD04	0.511	0.117
BXD05	0.628	-0.134
BXD06	0.692	-0.346
BXD07	0.338	-0.083
BXD08	0.853	0.216
BXD09	0.432	-0.271
CAST	0.23	-0.444
CCcont	0.876	0.826
DS01	-0.092	0.559
DS02	0.082	-0.361
DS04	-0.52	-0.072
DS0c	0.195	0.459
GP01	0.91	1.487
GP02	0.519	0.458
GP0c	-0.494	0.845
NOD	-0.062	-0.662
NZO	0.548	0.444
PWK	0.983	-0.225
H37Rv_KO_CtpC	0.027	0.134
H37Rv_KO_CtpD	-0.76	0.525
H37Rv_KO_Rv1272	-0.319	1.195
H37Rv_KO_SugABC	-0.146	0.38
H37Rv_KO_MbtN	-1.123	-1.147
Trans05	-0.059	0.448
macrophage_unactivated	-0.249	0.316
IL1	-0.424	0.219
Rapamycin	-0.439	0.954
Tcell	0.169	-0.368
GMCSF	-0.209	0.248
IFNab	-0.372	0.378
IFNg	0.032	0.059
IFNg_GMCSF1	0.559	0.839
Rv1432_day32	0.83	0.505
Rv1565c_day32	-0.502	-0.114
secA2_input	-0.067	0.327
delta_Rv3594	-0.698	-1.286
delta_Rv3717	-1.192	-1.315
delta_Rv3811	-1.037	-0.907
delta_Rv0954	-0.543	-0.499
PonA1	-0.383	-0.811
EccD1_KO	0.102	0.25
EspI_KO	0.676	0.756
PE35_KO	0.481	-0.233
PPE68_KO	0.47	0.077
glycerol2	1.275	1.199
lignocerate	1.458	0.938
oleate	0.559	-0.184
phosphatidylcholine	0.857	0.896
acetate	1.323	0.49
glucAc	1.288	0.392
Rv0950ko	-0.148	0.504
Rv1096ko	0.121	0.365
Rv3684ko	0.206	0.242
delta_otsA_trehalose	-2.021	-2.225