TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0934/pstS1:

update plot	correlation	link to info on gene
Rv0940c/-	(cc=0.6869)	info on Rv0940c/-
Rv3389c/htdY	(cc=0.6347)	info on Rv3389c/htdY
Rv3473c/bpoA	(cc=0.6326)	info on Rv3473c/bpoA
Rv1489A/-	(cc=0.6258)	info on Rv1489A/-
Rv2281/pitB	(cc=0.6159)	info on Rv2281/pitB
Rv1159A/-	(cc=0.5509)	info on Rv1159A/-
Rv1169c/lipX	(cc=0.5252)	info on Rv1169c/lipX
Rv0232/-	(cc=0.524)	info on Rv0232/-
Rv3508/PE_PGRS54	(cc=0.5202)	info on Rv3508/PE_PGRS54
Rv0343/iniC	(cc=0.5202)	info on Rv0343/iniC

Correlation of Rv0934/pstS1 with Rv2281/pitB

Normalized LFCs for Rv0934/pstS1:
(description and provenance of datasets)

	Rv0934/pstS1	Rv2281/pitB
Fe_supp_jason_reseq	-0.764	0.223
low_pH_jason_reseq	-0.391	-0.343
NO_jason_reseq	0.722	0.215
B6_jason_reseq	-0.065	0.28
MHCII_jason_reseq	0.128	-0.784
Isoniazid02	-1.689	-1.67
Rifampicin4	0.766	0.458
Ethambutol3	-2.021	0.555
Meropenem3	-1.711	-0.641
Vancomycin16	-0.52	-0.584
Rv2680_day32	0.066	0.336
H37Rv_KO_MarP	-0.069	-0.325
hypoxia_3wks	-0.419	-0.191
hypoxia_6wks	0.175	-0.1
glycerol	0.629	0.171
cholesterol	0.085	0.215
AJ	0.825	0.482
Bibs02	-0.389	0.155
Bibs02c	0.33	0.0
BL6	0.977	0.69
BL6a	0.304	0.469
BXD01	0.422	0.193
BXD010	0.584	0.456
BXD011	0.511	0.591
BXD03	0.348	-0.234
BXD04	0.511	-0.139
BXD05	0.628	0.28
BXD06	0.692	0.541
BXD07	0.338	0.643
BXD08	0.853	0.952
BXD09	0.432	1.115
CAST	0.23	0.27
CCcont	0.876	0.588
DS01	-0.092	0.69
DS02	0.082	0.605
DS04	-0.52	-0.419
DS0c	0.195	-0.614
GP01	0.91	0.147
GP02	0.519	1.022
GP0c	-0.494	-0.429
NOD	-0.062	0.298
NZO	0.548	0.834
PWK	0.983	0.068
H37Rv_KO_CtpC	0.027	0.165
H37Rv_KO_CtpD	-0.76	0.499
H37Rv_KO_Rv1272	-0.319	0.097
H37Rv_KO_SugABC	-0.146	0.673
H37Rv_KO_MbtN	-1.123	-0.316
Trans05	-0.059	0.515
macrophage_unactivated	-0.249	0.622
IL1	-0.424	0.35
Rapamycin	-0.439	0.052
Tcell	0.169	-0.482
GMCSF	-0.209	-0.29
IFNab	-0.372	0.051
IFNg	0.032	0.567
IFNg_GMCSF1	0.559	-0.465
Rv1432_day32	0.83	0.231
Rv1565c_day32	-0.502	-0.106
secA2_input	-0.067	0.277
delta_Rv3594	-0.698	0.34
delta_Rv3717	-1.192	-0.468
delta_Rv3811	-1.037	-1.184
delta_Rv0954	-0.543	-0.028
PonA1	-0.383	0.299
EccD1_KO	0.102	-0.164
EspI_KO	0.676	-0.682
PE35_KO	0.481	0.14
PPE68_KO	0.47	0.304
glycerol2	1.275	1.481
lignocerate	1.458	2.191
oleate	0.559	-0.084
phosphatidylcholine	0.857	1.867
acetate	1.323	2.364
glucAc	1.288	2.339
Rv0950ko	-0.148	0.066
Rv1096ko	0.121	0.383
Rv3684ko	0.206	-0.789
delta_otsA_trehalose	-2.021	-2.033