TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0918/-:

update plot	correlation	link to info on gene
Rv0071/-	(cc=0.5683)	info on Rv0071/-
Rv0615/-	(cc=0.5657)	info on Rv0615/-
Rv2627c/-	(cc=0.5305)	info on Rv2627c/-
Rv0303/-	(cc=0.5206)	info on Rv0303/-
Rv1192/-	(cc=0.5063)	info on Rv1192/-
Rv1181/pks4	(cc=0.5054)	info on Rv1181/pks4
Rv3450c/eccB4	(cc=0.5004)	info on Rv3450c/eccB4
Rv3606c/folK	(cc=0.4986)	info on Rv3606c/folK
Rv3612c/-	(cc=0.4985)	info on Rv3612c/-
Rv0221/-	(cc=0.4923)	info on Rv0221/-

Correlation of Rv0918/- with Rv1192/-

Normalized LFCs for Rv0918/-:
(description and provenance of datasets)

	Rv0918/-	Rv1192/-
Fe_supp_jason_reseq	-0.019	1.031
low_pH_jason_reseq	-1.362	-1.225
NO_jason_reseq	0.459	-0.189
B6_jason_reseq	0.781	1.83
MHCII_jason_reseq	1.154	1.815
Isoniazid02	0.112	0.377
Rifampicin4	-0.187	-0.125
Ethambutol3	1.223	1.46
Meropenem3	0.839	1.205
Vancomycin16	0.424	0.119
Rv2680_day32	2.915	1.037
H37Rv_KO_MarP	1.067	0.203
hypoxia_3wks	-0.797	-0.861
hypoxia_6wks	-0.042	-1.207
glycerol	-0.554	-1.119
cholesterol	0.024	-0.023
AJ	1.316	0.266
Bibs02	0.02	0.485
Bibs02c	0.706	0.377
BL6	-0.325	-0.701
BL6a	0.376	-0.218
BXD01	-0.509	-0.434
BXD010	-0.297	-1.013
BXD011	-1.106	-0.527
BXD03	-0.644	-0.481
BXD04	-1.75	-0.115
BXD05	-1.395	-1.431
BXD06	-0.671	-0.467
BXD07	-1.133	-0.623
BXD08	-0.183	-0.793
BXD09	-0.608	-0.899
CAST	-0.133	0.469
CCcont	-0.571	-0.592
DS01	0.065	1.167
DS02	0.512	0.429
DS04	0.607	1.526
DS0c	1.031	0.947
GP01	-2.828	-0.602
GP02	-1.939	0.033
GP0c	-0.857	-1.353
NOD	0.285	0.731
NZO	0.283	0.025
PWK	-0.033	0.374
H37Rv_KO_CtpC	0.238	-0.644
H37Rv_KO_CtpD	-0.796	-0.502
H37Rv_KO_Rv1272	-0.397	-0.653
H37Rv_KO_SugABC	-1.469	-0.293
H37Rv_KO_MbtN	-0.42	-1.325
Trans05	-0.428	-0.495
macrophage_unactivated	-1.341	0.092
IL1	-0.151	-0.329
Rapamycin	-1.065	-1.04
Tcell	-1.342	0.248
GMCSF	0.605	-0.465
IFNab	-0.898	-0.305
IFNg	-1.355	-0.81
IFNg_GMCSF1	-0.531	-0.418
Rv1432_day32	0.692	-0.92
Rv1565c_day32	-1.136	-0.573
secA2_input	-0.955	-0.177
delta_Rv3594	-0.561	0.659
delta_Rv3717	0.466	0.02
delta_Rv3811	0.474	0.946
delta_Rv0954	-0.557	1.187
PonA1	1.163	0.372
EccD1_KO	-1.187	-0.957
EspI_KO	-2.028	-0.2
PE35_KO	-1.762	-0.277
PPE68_KO	-2.176	-0.035
glycerol2	-0.39	0.935
lignocerate	0.0	1.103
oleate	-0.109	0.669
phosphatidylcholine	-0.297	1.139
acetate	-0.52	0.618
glucAc	0.224	0.666
Rv0950ko	0.169	0.648
Rv1096ko	1.098	0.682
Rv3684ko	0.734	0.383
delta_otsA_trehalose	0.66	-0.476