TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0795/-:

update plot	correlation	link to info on gene
Rv3474/-	(cc=0.801)	info on Rv3474/-
Rv1370c/-	(cc=0.7932)	info on Rv1370c/-
Rv2168c/-	(cc=0.7923)	info on Rv2168c/-
Rv3381c/-	(cc=0.7273)	info on Rv3381c/-
Rv2648/-	(cc=0.7007)	info on Rv2648/-
Rv2815c/-	(cc=0.6988)	info on Rv2815c/-
Rv3186/-	(cc=0.6748)	info on Rv3186/-
Rv2278/-	(cc=0.6641)	info on Rv2278/-
Rv2354/-	(cc=0.6641)	info on Rv2354/-
Rv2480c/-	(cc=0.6605)	info on Rv2480c/-

Correlation of Rv0795/- with Rv3381c/-

Normalized LFCs for Rv0795/-:
(description and provenance of datasets)

	Rv0795/-	Rv3381c/-
Fe_supp_jason_reseq	0.079	0.027
low_pH_jason_reseq	1.603	0.413
NO_jason_reseq	0.034	0.137
B6_jason_reseq	-0.974	-0.307
MHCII_jason_reseq	-0.578	0.322
Isoniazid02	-0.073	-0.191
Rifampicin4	0.452	0.068
Ethambutol3	1.229	1.231
Meropenem3	-0.246	-0.375
Vancomycin16	0.13	-0.066
Rv2680_day32	-0.092	0.005
H37Rv_KO_MarP	-0.095	-0.234
hypoxia_3wks	0.937	0.865
hypoxia_6wks	-0.115	0.0
glycerol	-0.404	-0.654
cholesterol	0.035	-0.163
AJ	1.106	1.198
Bibs02	-0.136	0.102
Bibs02c	0.705	0.9
BL6	-0.471	-0.594
BL6a	0.736	0.37
BXD01	0.484	-0.016
BXD010	0.551	0.163
BXD011	0.895	-0.021
BXD03	0.927	0.096
BXD04	0.223	-0.263
BXD05	1.063	0.332
BXD06	0.417	0.121
BXD07	0.626	0.221
BXD08	0.323	-0.131
BXD09	0.493	-0.314
CAST	0.839	0.649
CCcont	-0.352	-0.727
DS01	-0.068	0.696
DS02	0.339	0.627
DS04	-0.247	0.559
DS0c	0.338	1.105
GP01	1.127	0.821
GP02	1.331	1.283
GP0c	0.461	0.175
NOD	0.106	0.295
NZO	1.035	1.045
PWK	1.017	1.38
H37Rv_KO_CtpC	0.473	0.542
H37Rv_KO_CtpD	0.223	0.184
H37Rv_KO_Rv1272	0.0	-0.139
H37Rv_KO_SugABC	-0.054	-0.206
H37Rv_KO_MbtN	0.953	0.939
Trans05	0.376	0.348
macrophage_unactivated	-0.578	-1.001
IL1	-0.587	-1.166
Rapamycin	-0.166	-0.608
Tcell	-0.088	-1.916
GMCSF	-0.18	-0.504
IFNab	-0.883	-1.11
IFNg	0.053	-0.847
IFNg_GMCSF1	0.493	0.082
Rv1432_day32	0.782	1.245
Rv1565c_day32	-0.164	-0.322
secA2_input	-0.258	-0.127
delta_Rv3594	-0.151	-0.047
delta_Rv3717	-0.172	-0.262
delta_Rv3811	-0.428	-0.352
delta_Rv0954	0.182	-0.063
PonA1	-0.248	-0.871
EccD1_KO	-1.2	-0.539
EspI_KO	-0.023	0.887
PE35_KO	0.671	0.744
PPE68_KO	-0.576	0.435
glycerol2	0.163	0.284
lignocerate	0.15	0.118
oleate	-0.401	0.149
phosphatidylcholine	-0.053	0.228
acetate	1.593	2.045
glucAc	1.894	2.18
Rv0950ko	0.543	0.332
Rv1096ko	0.875	0.274
Rv3684ko	-0.354	0.016
delta_otsA_trehalose	0.193	0.201