TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0795/-:

update plot	correlation	link to info on gene
Rv3474/-	(cc=0.801)	info on Rv3474/-
Rv1370c/-	(cc=0.7932)	info on Rv1370c/-
Rv2168c/-	(cc=0.7923)	info on Rv2168c/-
Rv3381c/-	(cc=0.7273)	info on Rv3381c/-
Rv2648/-	(cc=0.7007)	info on Rv2648/-
Rv2815c/-	(cc=0.6988)	info on Rv2815c/-
Rv3186/-	(cc=0.6748)	info on Rv3186/-
Rv2278/-	(cc=0.6641)	info on Rv2278/-
Rv2354/-	(cc=0.6641)	info on Rv2354/-
Rv2480c/-	(cc=0.6605)	info on Rv2480c/-

Correlation of Rv0795/- with Rv2278/-

Normalized LFCs for Rv0795/-:
(description and provenance of datasets)

	Rv0795/-	Rv2278/-
Fe_supp_jason_reseq	0.079	-0.826
low_pH_jason_reseq	1.603	0.805
NO_jason_reseq	0.034	-0.78
B6_jason_reseq	-0.974	-1.946
MHCII_jason_reseq	-0.578	-0.839
Isoniazid02	-0.073	0.322
Rifampicin4	0.452	1.118
Ethambutol3	1.229	1.45
Meropenem3	-0.246	0.079
Vancomycin16	0.13	0.358
Rv2680_day32	-0.092	-0.034
H37Rv_KO_MarP	-0.095	-0.38
hypoxia_3wks	0.937	0.981
hypoxia_6wks	-0.115	-0.04
glycerol	-0.404	-0.499
cholesterol	0.035	0.132
AJ	1.106	1.676
Bibs02	-0.136	-0.028
Bibs02c	0.705	0.662
BL6	-0.471	-0.196
BL6a	0.736	0.72
BXD01	0.484	0.682
BXD010	0.551	0.599
BXD011	0.895	0.34
BXD03	0.927	0.716
BXD04	0.223	0.948
BXD05	1.063	0.811
BXD06	0.417	0.462
BXD07	0.626	0.774
BXD08	0.323	0.461
BXD09	0.493	0.221
CAST	0.839	0.909
CCcont	-0.352	-0.251
DS01	-0.068	-0.096
DS02	0.339	-0.044
DS04	-0.247	0.122
DS0c	0.338	0.434
GP01	1.127	1.114
GP02	1.331	1.244
GP0c	0.461	0.677
NOD	0.106	0.373
NZO	1.035	1.003
PWK	1.017	1.6
H37Rv_KO_CtpC	0.473	0.631
H37Rv_KO_CtpD	0.223	0.0
H37Rv_KO_Rv1272	0.0	0.191
H37Rv_KO_SugABC	-0.054	-0.161
H37Rv_KO_MbtN	0.953	0.982
Trans05	0.376	0.787
macrophage_unactivated	-0.578	-0.518
IL1	-0.587	-1.548
Rapamycin	-0.166	-1.602
Tcell	-0.088	-1.251
GMCSF	-0.18	-0.618
IFNab	-0.883	-1.521
IFNg	0.053	-0.54
IFNg_GMCSF1	0.493	-0.107
Rv1432_day32	0.782	1.314
Rv1565c_day32	-0.164	-0.133
secA2_input	-0.258	-0.409
delta_Rv3594	-0.151	-0.046
delta_Rv3717	-0.172	-0.229
delta_Rv3811	-0.428	-0.348
delta_Rv0954	0.182	0.234
PonA1	-0.248	-0.321
EccD1_KO	-1.2	1.161
EspI_KO	-0.023	1.397
PE35_KO	0.671	1.747
PPE68_KO	-0.576	1.549
glycerol2	0.163	-0.185
lignocerate	0.15	-0.329
oleate	-0.401	0.044
phosphatidylcholine	-0.053	-0.326
acetate	1.593	0.781
glucAc	1.894	1.395
Rv0950ko	0.543	0.582
Rv1096ko	0.875	0.458
Rv3684ko	-0.354	-0.026
delta_otsA_trehalose	0.193	0.895