TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0795/-:

update plot	correlation	link to info on gene
Rv3474/-	(cc=0.801)	info on Rv3474/-
Rv1370c/-	(cc=0.7932)	info on Rv1370c/-
Rv2168c/-	(cc=0.7923)	info on Rv2168c/-
Rv3381c/-	(cc=0.7273)	info on Rv3381c/-
Rv2648/-	(cc=0.7007)	info on Rv2648/-
Rv2815c/-	(cc=0.6988)	info on Rv2815c/-
Rv3186/-	(cc=0.6748)	info on Rv3186/-
Rv2278/-	(cc=0.6641)	info on Rv2278/-
Rv2354/-	(cc=0.6641)	info on Rv2354/-
Rv2480c/-	(cc=0.6605)	info on Rv2480c/-

Correlation of Rv0795/- with Rv3186/-

Normalized LFCs for Rv0795/-:
(description and provenance of datasets)

	Rv0795/-	Rv3186/-
Fe_supp_jason_reseq	0.079	-0.172
low_pH_jason_reseq	1.603	0.915
NO_jason_reseq	0.034	-0.037
B6_jason_reseq	-0.974	-0.497
MHCII_jason_reseq	-0.578	0.0
Isoniazid02	-0.073	-0.083
Rifampicin4	0.452	0.29
Ethambutol3	1.229	1.115
Meropenem3	-0.246	-0.198
Vancomycin16	0.13	-0.058
Rv2680_day32	-0.092	-0.285
H37Rv_KO_MarP	-0.095	-0.291
hypoxia_3wks	0.937	0.797
hypoxia_6wks	-0.115	0.24
glycerol	-0.404	-0.489
cholesterol	0.035	0.069
AJ	1.106	1.371
Bibs02	-0.136	0.228
Bibs02c	0.705	0.917
BL6	-0.471	0.381
BL6a	0.736	0.937
BXD01	0.484	0.297
BXD010	0.551	0.637
BXD011	0.895	0.397
BXD03	0.927	0.648
BXD04	0.223	0.452
BXD05	1.063	0.924
BXD06	0.417	0.491
BXD07	0.626	0.638
BXD08	0.323	0.171
BXD09	0.493	0.386
CAST	0.839	0.452
CCcont	-0.352	-0.13
DS01	-0.068	0.157
DS02	0.339	0.345
DS04	-0.247	-0.118
DS0c	0.338	0.134
GP01	1.127	1.048
GP02	1.331	1.249
GP0c	0.461	0.675
NOD	0.106	0.021
NZO	1.035	1.162
PWK	1.017	1.081
H37Rv_KO_CtpC	0.473	0.108
H37Rv_KO_CtpD	0.223	-0.438
H37Rv_KO_Rv1272	0.0	0.126
H37Rv_KO_SugABC	-0.054	-0.24
H37Rv_KO_MbtN	0.953	0.841
Trans05	0.376	0.416
macrophage_unactivated	-0.578	0.051
IL1	-0.587	-0.593
Rapamycin	-0.166	-1.728
Tcell	-0.088	-1.577
GMCSF	-0.18	-1.061
IFNab	-0.883	-1.261
IFNg	0.053	-0.516
IFNg_GMCSF1	0.493	-0.933
Rv1432_day32	0.782	3.988
Rv1565c_day32	-0.164	0.032
secA2_input	-0.258	0.124
delta_Rv3594	-0.151	-0.135
delta_Rv3717	-0.172	-0.54
delta_Rv3811	-0.428	-0.568
delta_Rv0954	0.182	0.027
PonA1	-0.248	-0.076
EccD1_KO	-1.2	-0.72
EspI_KO	-0.023	0.319
PE35_KO	0.671	0.61
PPE68_KO	-0.576	-0.141
glycerol2	0.163	-0.367
lignocerate	0.15	-0.319
oleate	-0.401	-0.464
phosphatidylcholine	-0.053	-0.139
acetate	1.593	0.708
glucAc	1.894	1.398
Rv0950ko	0.543	0.09
Rv1096ko	0.875	0.223
Rv3684ko	-0.354	-0.102
delta_otsA_trehalose	0.193	0.66