TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0769/-:

update plot	correlation	link to info on gene
Rv3165c/-	(cc=0.4668)	info on Rv3165c/-
Rv3852/hns	(cc=0.4594)	info on Rv3852/hns
Rv3085/-	(cc=0.4391)	info on Rv3085/-
Rv1219c/-	(cc=0.4199)	info on Rv1219c/-
Rv2240c/-	(cc=0.415)	info on Rv2240c/-
Rv1524/-	(cc=0.4132)	info on Rv1524/-
Rv1404/-	(cc=0.4128)	info on Rv1404/-
Rv2060/-	(cc=0.4017)	info on Rv2060/-
Rv0548c/menB	(cc=0.3924)	info on Rv0548c/menB
Rv1473A/-	(cc=0.3917)	info on Rv1473A/-

Correlation of Rv0769/- with Rv1404/-

Normalized LFCs for Rv0769/-:
(description and provenance of datasets)

	Rv0769/-	Rv1404/-
Fe_supp_jason_reseq	0.612	2.382
low_pH_jason_reseq	-0.53	-1.328
NO_jason_reseq	0.722	0.281
B6_jason_reseq	0.533	1.228
MHCII_jason_reseq	0.951	-0.776
Isoniazid02	-0.356	0.332
Rifampicin4	-1.151	0.422
Ethambutol3	0.131	0.235
Meropenem3	0.47	0.395
Vancomycin16	-0.523	-0.589
Rv2680_day32	0.816	0.803
H37Rv_KO_MarP	0.217	0.478
hypoxia_3wks	-0.439	0.287
hypoxia_6wks	0.188	-0.159
glycerol	-0.461	-1.862
cholesterol	0.061	-1.612
AJ	-0.264	-0.671
Bibs02	-0.596	-2.035
Bibs02c	-1.449	-2.12
BL6	0.267	0.993
BL6a	0.184	0.0
BXD01	0.027	-0.048
BXD010	0.144	1.358
BXD011	0.191	0.968
BXD03	0.241	1.162
BXD04	0.733	0.167
BXD05	0.713	-0.209
BXD06	0.766	1.229
BXD07	0.284	0.352
BXD08	0.722	0.729
BXD09	1.099	1.092
CAST	0.741	-1.018
CCcont	0.838	1.732
DS01	-0.051	-2.178
DS02	-0.328	-0.249
DS04	-1.226	-0.753
DS0c	-0.3	-0.958
GP01	-0.84	-1.099
GP02	-0.146	-0.926
GP0c	-0.297	-1.199
NOD	0.024	-1.119
NZO	-0.251	-0.994
PWK	0.35	-1.809
H37Rv_KO_CtpC	1.105	-1.808
H37Rv_KO_CtpD	-0.239	-0.787
H37Rv_KO_Rv1272	-0.127	-0.972
H37Rv_KO_SugABC	-0.1	1.453
H37Rv_KO_MbtN	-0.069	-0.348
Trans05	-0.028	-0.812
macrophage_unactivated	0.499	-0.89
IL1	0.605	0.641
Rapamycin	0.187	-0.611
Tcell	0.033	0.433
GMCSF	0.214	0.57
IFNab	0.508	0.889
IFNg	0.216	0.123
IFNg_GMCSF1	0.698	0.55
Rv1432_day32	0.0	-0.961
Rv1565c_day32	0.235	-0.114
secA2_input	0.668	0.0
delta_Rv3594	0.583	1.326
delta_Rv3717	0.424	0.384
delta_Rv3811	-0.271	2.357
delta_Rv0954	-0.504	0.302
PonA1	-0.479	0.503
EccD1_KO	0.138	-1.131
EspI_KO	1.708	2.321
PE35_KO	0.522	0.481
PPE68_KO	0.806	0.272
glycerol2	0.705	-0.347
lignocerate	1.109	0.712
oleate	-0.793	-2.535
phosphatidylcholine	0.392	-0.618
acetate	1.084	0.459
glucAc	1.095	0.777
Rv0950ko	0.199	1.683
Rv1096ko	0.962	-0.941
Rv3684ko	1.176	-0.134
delta_otsA_trehalose	2.083	0.239