TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0701/rplC:

update plot	correlation	link to info on gene
Rv3673c/-	(cc=0.9187)	info on Rv3673c/-
Rv2678c/hemE	(cc=0.799)	info on Rv2678c/hemE
Rv2882c/frr	(cc=0.7923)	info on Rv2882c/frr
Rv2164c/-	(cc=0.6902)	info on Rv2164c/-
Rv3858c/gltD	(cc=0.6779)	info on Rv3858c/gltD
Rv2373c/dnaJ2	(cc=0.6688)	info on Rv2373c/dnaJ2
Rv2611c/-	(cc=0.6669)	info on Rv2611c/-
Rv1177/fdxC	(cc=0.6649)	info on Rv1177/fdxC
Rv3753c/-	(cc=0.6627)	info on Rv3753c/-
Rv3456c/rplQ	(cc=0.662)	info on Rv3456c/rplQ

Correlation of Rv0701/rplC with Rv2611c/-

Normalized LFCs for Rv0701/rplC:
(description and provenance of datasets)

	Rv0701/rplC	Rv2611c/-
Fe_supp_jason_reseq	0.0	0.0
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	-0.292
MHCII_jason_reseq	0.0	-0.257
Isoniazid02	0.0	0.0
Rifampicin4	0.0	0.0
Ethambutol3	0.0	0.32
Meropenem3	0.0	0.0
Vancomycin16	0.0	0.0
Rv2680_day32	0.0	-1.406
H37Rv_KO_MarP	0.0	-0.957
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	0.0	0.0
cholesterol	0.0	0.0
AJ	0.0	0.0
Bibs02	0.0	0.0
Bibs02c	0.0	0.0
BL6	0.0	0.0
BL6a	0.0	0.0
BXD01	0.0	0.0
BXD010	0.0	0.0
BXD011	0.0	0.0
BXD03	0.0	0.0
BXD04	0.0	0.0
BXD05	0.0	0.0
BXD06	0.0	0.0
BXD07	0.0	0.0
BXD08	0.0	0.0
BXD09	0.0	0.0
CAST	0.0	0.0
CCcont	0.0	0.285
DS01	0.0	0.0
DS02	0.0	0.0
DS04	0.0	0.0
DS0c	0.0	0.0
GP01	0.0	0.0
GP02	0.0	0.0
GP0c	0.13	0.0
NOD	0.0	0.0
NZO	0.0	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	0.0	0.0
H37Rv_KO_CtpD	0.0	0.127
H37Rv_KO_Rv1272	0.0	0.0
H37Rv_KO_SugABC	0.0	0.0
H37Rv_KO_MbtN	0.0	0.0
Trans05	0.0	0.0
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	1.675	-0.302
delta_Rv3594	0.0	0.211
delta_Rv3717	0.0	0.331
delta_Rv3811	0.0	0.391
delta_Rv0954	0.0	0.0
PonA1	0.0	0.304
EccD1_KO	-1.47	-2.654
EspI_KO	-1.668	-0.87
PE35_KO	-1.706	-2.018
PPE68_KO	-1.872	-2.985
glycerol2	0.0	-0.193
lignocerate	0.0	0.0
oleate	0.0	-0.196
phosphatidylcholine	0.0	0.0
acetate	0.0	1.044
glucAc	0.0	1.034
Rv0950ko	0.0	-0.323
Rv1096ko	0.0	-1.463
Rv3684ko	0.0	-0.727
delta_otsA_trehalose	0.254	-0.133