TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0659c/mazF2:

update plot	correlation	link to info on gene
Rv1702c/-	(cc=0.4413)	info on Rv1702c/-
Rv2630/-	(cc=0.4299)	info on Rv2630/-
Rv0902c/prrB	(cc=0.4259)	info on Rv0902c/prrB
Rv3111/moaC1	(cc=0.4224)	info on Rv3111/moaC1
Rv2221c/glnE	(cc=0.4168)	info on Rv2221c/glnE
Rv2128/-	(cc=0.4038)	info on Rv2128/-
Rv3066/-	(cc=0.4014)	info on Rv3066/-
Rv3208/-	(cc=0.3855)	info on Rv3208/-
Rv2874/dipZ	(cc=0.3815)	info on Rv2874/dipZ
Rv0489/gpm1	(cc=0.3754)	info on Rv0489/gpm1

Correlation of Rv0659c/mazF2 with Rv3208/-

Normalized LFCs for Rv0659c/mazF2:
(description and provenance of datasets)

	Rv0659c/mazF2	Rv3208/-
Fe_supp_jason_reseq	2.262	4.191
low_pH_jason_reseq	0.074	0.0
NO_jason_reseq	0.811	0.0
B6_jason_reseq	1.417	0.0
MHCII_jason_reseq	2.051	0.0
Isoniazid02	-0.019	0.0
Rifampicin4	0.271	0.0
Ethambutol3	-0.072	0.0
Meropenem3	0.468	0.0
Vancomycin16	0.793	0.0
Rv2680_day32	0.197	0.0
H37Rv_KO_MarP	-0.714	-1.705
hypoxia_3wks	0.108	-0.55
hypoxia_6wks	-0.102	-0.288
glycerol	-0.187	0.0
cholesterol	-0.725	0.0
AJ	0.03	0.0
Bibs02	0.375	0.0
Bibs02c	0.108	0.0
BL6	0.655	0.768
BL6a	0.217	0.0
BXD01	-0.687	0.0
BXD010	-0.021	0.352
BXD011	0.261	0.35
BXD03	-0.069	0.0
BXD04	-0.236	0.0
BXD05	0.319	0.135
BXD06	0.303	0.0
BXD07	0.027	0.0
BXD08	0.912	0.0
BXD09	0.054	0.0
CAST	0.404	0.0
CCcont	-0.345	1.43
DS01	0.453	0.0
DS02	0.295	0.0
DS04	0.989	0.682
DS0c	-0.396	0.0
GP01	-0.554	0.0
GP02	0.24	0.0
GP0c	0.291	0.357
NOD	0.773	0.0
NZO	-0.094	0.0
PWK	1.204	0.0
H37Rv_KO_CtpC	0.062	0.0
H37Rv_KO_CtpD	-0.703	0.0
H37Rv_KO_Rv1272	1.723	0.141
H37Rv_KO_SugABC	0.794	0.348
H37Rv_KO_MbtN	-0.98	0.196
Trans05	0.755	0.131
macrophage_unactivated	1.035	0.398
IL1	-0.131	0.374
Rapamycin	0.779	1.068
Tcell	0.0	0.0
GMCSF	0.848	0.333
IFNab	0.375	0.729
IFNg	0.126	0.93
IFNg_GMCSF1	1.21	0.396
Rv1432_day32	-0.332	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-1.644	-1.368
delta_Rv3594	-0.018	1.487
delta_Rv3717	-0.725	1.223
delta_Rv3811	-0.21	-0.171
delta_Rv0954	-0.496	-0.149
PonA1	-0.739	-0.204
EccD1_KO	-0.095	-1.204
EspI_KO	-0.299	0.0
PE35_KO	0.128	-2.981
PPE68_KO	0.154	-2.742
glycerol2	-0.499	-0.82
lignocerate	-0.11	-0.712
oleate	-0.421	-0.829
phosphatidylcholine	-0.499	-0.819
acetate	-0.209	-0.973
glucAc	0.021	-0.605
Rv0950ko	-0.19	0.311
Rv1096ko	-0.054	-0.513
Rv3684ko	-0.255	0.17
delta_otsA_trehalose	0.068	0.0