TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0659c/mazF2:

update plot	correlation	link to info on gene
Rv1702c/-	(cc=0.4413)	info on Rv1702c/-
Rv2630/-	(cc=0.4299)	info on Rv2630/-
Rv0902c/prrB	(cc=0.4259)	info on Rv0902c/prrB
Rv3111/moaC1	(cc=0.4224)	info on Rv3111/moaC1
Rv2221c/glnE	(cc=0.4168)	info on Rv2221c/glnE
Rv2128/-	(cc=0.4038)	info on Rv2128/-
Rv3066/-	(cc=0.4014)	info on Rv3066/-
Rv3208/-	(cc=0.3855)	info on Rv3208/-
Rv2874/dipZ	(cc=0.3815)	info on Rv2874/dipZ
Rv0489/gpm1	(cc=0.3754)	info on Rv0489/gpm1

Correlation of Rv0659c/mazF2 with Rv1702c/-

Normalized LFCs for Rv0659c/mazF2:
(description and provenance of datasets)

	Rv0659c/mazF2	Rv1702c/-
Fe_supp_jason_reseq	2.262	0.508
low_pH_jason_reseq	0.074	-1.246
NO_jason_reseq	0.811	0.504
B6_jason_reseq	1.417	0.204
MHCII_jason_reseq	2.051	0.512
Isoniazid02	-0.019	0.0
Rifampicin4	0.271	0.027
Ethambutol3	-0.072	-0.063
Meropenem3	0.468	-0.252
Vancomycin16	0.793	0.135
Rv2680_day32	0.197	-0.432
H37Rv_KO_MarP	-0.714	0.025
hypoxia_3wks	0.108	-0.159
hypoxia_6wks	-0.102	-0.367
glycerol	-0.187	0.164
cholesterol	-0.725	-0.155
AJ	0.03	0.326
Bibs02	0.375	0.789
Bibs02c	0.108	0.123
BL6	0.655	-0.422
BL6a	0.217	0.257
BXD01	-0.687	-0.032
BXD010	-0.021	0.35
BXD011	0.261	0.159
BXD03	-0.069	0.117
BXD04	-0.236	-0.133
BXD05	0.319	0.231
BXD06	0.303	-0.024
BXD07	0.027	-0.304
BXD08	0.912	0.085
BXD09	0.054	-0.078
CAST	0.404	0.122
CCcont	-0.345	-0.444
DS01	0.453	-0.072
DS02	0.295	-0.054
DS04	0.989	0.86
DS0c	-0.396	-0.107
GP01	-0.554	-0.024
GP02	0.24	0.332
GP0c	0.291	0.112
NOD	0.773	0.08
NZO	-0.094	0.507
PWK	1.204	0.48
H37Rv_KO_CtpC	0.062	-0.111
H37Rv_KO_CtpD	-0.703	-0.56
H37Rv_KO_Rv1272	1.723	0.19
H37Rv_KO_SugABC	0.794	0.595
H37Rv_KO_MbtN	-0.98	-0.576
Trans05	0.755	0.217
macrophage_unactivated	1.035	0.35
IL1	-0.131	0.635
Rapamycin	0.779	0.552
Tcell	0.0	0.026
GMCSF	0.848	0.581
IFNab	0.375	0.269
IFNg	0.126	0.021
IFNg_GMCSF1	1.21	0.588
Rv1432_day32	-0.332	0.242
Rv1565c_day32	0.0	-0.161
secA2_input	-1.644	0.157
delta_Rv3594	-0.018	-0.255
delta_Rv3717	-0.725	-0.333
delta_Rv3811	-0.21	-0.18
delta_Rv0954	-0.496	0.446
PonA1	-0.739	-0.381
EccD1_KO	-0.095	0.717
EspI_KO	-0.299	0.365
PE35_KO	0.128	-0.411
PPE68_KO	0.154	0.346
glycerol2	-0.499	-0.485
lignocerate	-0.11	-0.145
oleate	-0.421	-0.115
phosphatidylcholine	-0.499	0.119
acetate	-0.209	-0.449
glucAc	0.021	-0.279
Rv0950ko	-0.19	0.265
Rv1096ko	-0.054	-0.069
Rv3684ko	-0.255	-0.229
delta_otsA_trehalose	0.068	-0.323