TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0633c/-:

update plot	correlation	link to info on gene
Rv0347/-	(cc=0.5655)	info on Rv0347/-
Rv2392/cysH	(cc=0.5297)	info on Rv2392/cysH
Rv0650/-	(cc=0.5139)	info on Rv0650/-
Rv0631c/recC	(cc=0.5096)	info on Rv0631c/recC
Rv2672/-	(cc=0.4924)	info on Rv2672/-
Rv0634A/-	(cc=0.483)	info on Rv0634A/-
Rv1178/-	(cc=0.4685)	info on Rv1178/-
Rv0673/echA4	(cc=0.4624)	info on Rv0673/echA4
Rv0435c/-	(cc=0.4604)	info on Rv0435c/-
Rv0300/vapB2	(cc=0.4561)	info on Rv0300/vapB2

Correlation of Rv0633c/- with Rv0650/-

Normalized LFCs for Rv0633c/-:
(description and provenance of datasets)

	Rv0633c/-	Rv0650/-
Fe_supp_jason_reseq	0.415	-1.301
low_pH_jason_reseq	-0.738	-0.748
NO_jason_reseq	-0.945	-0.772
B6_jason_reseq	0.198	-0.437
MHCII_jason_reseq	0.257	0.252
Isoniazid02	0.432	0.639
Rifampicin4	0.133	1.481
Ethambutol3	0.978	1.792
Meropenem3	0.68	0.304
Vancomycin16	0.186	0.735
Rv2680_day32	-0.867	0.326
H37Rv_KO_MarP	0.222	0.446
hypoxia_3wks	0.128	-0.235
hypoxia_6wks	-0.451	-1.503
glycerol	-0.015	2.342
cholesterol	0.486	1.387
AJ	-0.588	1.168
Bibs02	-0.007	0.503
Bibs02c	-0.453	1.44
BL6	0.361	0.63
BL6a	-0.014	0.684
BXD01	-0.601	-0.164
BXD010	-0.643	0.486
BXD011	-0.475	-0.383
BXD03	-0.13	-0.73
BXD04	-0.606	-0.692
BXD05	0.458	-1.163
BXD06	-0.478	-0.37
BXD07	0.159	-0.042
BXD08	-0.92	0.366
BXD09	-0.298	-0.235
CAST	0.265	0.402
CCcont	-0.473	0.913
DS01	0.068	1.738
DS02	0.236	1.47
DS04	-0.073	-0.422
DS0c	-0.132	1.466
GP01	0.26	0.919
GP02	-0.905	0.057
GP0c	-0.438	0.669
NOD	-0.348	0.805
NZO	0.087	0.308
PWK	-0.126	0.627
H37Rv_KO_CtpC	-0.435	-0.752
H37Rv_KO_CtpD	-0.528	0.661
H37Rv_KO_Rv1272	-0.708	-0.095
H37Rv_KO_SugABC	0.421	0.316
H37Rv_KO_MbtN	-0.998	-2.29
Trans05	-0.58	0.298
macrophage_unactivated	-0.464	0.574
IL1	0.546	2.058
Rapamycin	0.89	0.672
Tcell	0.326	-0.368
GMCSF	0.605	0.322
IFNab	0.771	0.846
IFNg	0.492	0.668
IFNg_GMCSF1	0.314	0.927
Rv1432_day32	-1.269	0.692
Rv1565c_day32	0.158	-0.415
secA2_input	0.571	1.669
delta_Rv3594	0.162	-0.463
delta_Rv3717	-0.259	0.515
delta_Rv3811	-0.17	-0.076
delta_Rv0954	0.393	1.26
PonA1	0.617	0.375
EccD1_KO	0.464	1.151
EspI_KO	-0.445	0.325
PE35_KO	0.432	-0.814
PPE68_KO	0.173	-0.566
glycerol2	-0.755	0.137
lignocerate	-0.449	0.788
oleate	-0.44	-0.544
phosphatidylcholine	-0.647	0.416
acetate	-0.216	-0.115
glucAc	0.605	0.453
Rv0950ko	1.098	1.493
Rv1096ko	2.117	3.088
Rv3684ko	2.103	3.76
delta_otsA_trehalose	-0.801	-0.197