TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0567/-:

update plot	correlation	link to info on gene
Rv0327c/cyp135A1	(cc=0.5657)	info on Rv0327c/cyp135A1
Rv0794c/-	(cc=0.5311)	info on Rv0794c/-
Rv3777/-	(cc=0.4983)	info on Rv3777/-
Rv2998/-	(cc=0.4873)	info on Rv2998/-
Rv0024/-	(cc=0.481)	info on Rv0024/-
Rv2424c/-	(cc=0.4761)	info on Rv2424c/-
Rv3325/-	(cc=0.4685)	info on Rv3325/-
Rv1200/-	(cc=0.4522)	info on Rv1200/-
Rv2644c/-	(cc=0.4498)	info on Rv2644c/-
Rv2915c/-	(cc=0.4485)	info on Rv2915c/-

Correlation of Rv0567/- with Rv3325/-

Normalized LFCs for Rv0567/-:
(description and provenance of datasets)

	Rv0567/-	Rv3325/-
Fe_supp_jason_reseq	0.18	-0.032
low_pH_jason_reseq	-0.55	0.187
NO_jason_reseq	-0.347	-0.391
B6_jason_reseq	0.591	0.174
MHCII_jason_reseq	0.752	-0.044
Isoniazid02	0.033	0.211
Rifampicin4	0.295	0.931
Ethambutol3	0.338	1.294
Meropenem3	-0.272	-0.095
Vancomycin16	-0.186	0.411
Rv2680_day32	-1.09	-0.624
H37Rv_KO_MarP	0.19	-0.333
hypoxia_3wks	0.662	0.809
hypoxia_6wks	0.825	-0.203
glycerol	-0.358	-1.147
cholesterol	-0.516	-0.305
AJ	0.182	1.17
Bibs02	0.629	0.074
Bibs02c	0.306	0.353
BL6	0.187	-0.304
BL6a	0.227	0.264
BXD01	-0.481	-0.101
BXD010	0.384	0.192
BXD011	0.374	0.178
BXD03	0.128	0.078
BXD04	0.293	-0.096
BXD05	-0.224	0.311
BXD06	0.142	-0.164
BXD07	0.017	0.095
BXD08	-0.184	-0.186
BXD09	-0.043	0.196
CAST	0.294	0.532
CCcont	-0.187	-0.363
DS01	-0.022	0.37
DS02	0.115	0.509
DS04	-0.7	0.119
DS0c	0.68	1.023
GP01	0.528	0.771
GP02	0.379	1.281
GP0c	-0.486	0.556
NOD	0.404	0.083
NZO	0.364	0.964
PWK	0.266	1.069
H37Rv_KO_CtpC	-0.777	0.089
H37Rv_KO_CtpD	-0.575	0.114
H37Rv_KO_Rv1272	-0.377	-0.259
H37Rv_KO_SugABC	-0.344	-0.232
H37Rv_KO_MbtN	-0.417	0.67
Trans05	-0.094	0.009
macrophage_unactivated	0.057	-1.244
IL1	-0.558	-1.21
Rapamycin	-0.528	-0.601
Tcell	-0.059	-0.899
GMCSF	-0.246	-1.188
IFNab	-0.475	-1.11
IFNg	-0.11	-1.299
IFNg_GMCSF1	-0.415	-0.578
Rv1432_day32	0.169	1.314
Rv1565c_day32	-0.368	-0.311
secA2_input	-0.094	-0.013
delta_Rv3594	-1.037	0.45
delta_Rv3717	-0.708	-0.145
delta_Rv3811	-0.294	-0.208
delta_Rv0954	-0.227	0.324
PonA1	-0.464	-0.308
EccD1_KO	1.039	0.237
EspI_KO	0.761	1.292
PE35_KO	0.741	1.07
PPE68_KO	0.854	0.88
glycerol2	0.406	-0.245
lignocerate	0.744	-0.184
oleate	-0.4	-0.668
phosphatidylcholine	0.459	-0.245
acetate	0.359	1.081
glucAc	0.423	1.52
Rv0950ko	0.597	0.811
Rv1096ko	0.338	0.534
Rv3684ko	0.088	0.108
delta_otsA_trehalose	-0.88	-0.317