TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0497/-:

update plot	correlation	link to info on gene
Rv1836c/-	(cc=0.6274)	info on Rv1836c/-
Rv3854c/ethA	(cc=0.6185)	info on Rv3854c/ethA
Rv1821/secA2	(cc=0.6117)	info on Rv1821/secA2
Rv1111c/-	(cc=0.6082)	info on Rv1111c/-
Rv2190c/-	(cc=0.5803)	info on Rv2190c/-
Rv2696c/-	(cc=0.529)	info on Rv2696c/-
Rv0385/-	(cc=0.5272)	info on Rv0385/-
Rv3207c/-	(cc=0.52)	info on Rv3207c/-
Rv2553c/-	(cc=0.5089)	info on Rv2553c/-
Rv0049/-	(cc=0.4992)	info on Rv0049/-

Correlation of Rv0497/- with Rv3207c/-

Normalized LFCs for Rv0497/-:
(description and provenance of datasets)

	Rv0497/-	Rv3207c/-
Fe_supp_jason_reseq	2.155	2.441
low_pH_jason_reseq	-1.887	-0.415
NO_jason_reseq	0.858	-3.783
B6_jason_reseq	-1.375	-1.385
MHCII_jason_reseq	-1.155	0.141
Isoniazid02	-1.622	-1.224
Rifampicin4	-1.66	-2.989
Ethambutol3	-0.19	-0.546
Meropenem3	-1.154	-0.283
Vancomycin16	-2.555	-3.783
Rv2680_day32	1.148	0.095
H37Rv_KO_MarP	-3.88	-5.574
hypoxia_3wks	-1.244	-2.759
hypoxia_6wks	-1.038	-3.101
glycerol	-1.24	0.325
cholesterol	0.748	1.336
AJ	0.487	-0.324
Bibs02	-0.697	-0.775
Bibs02c	-1.773	-1.341
BL6	0.731	0.292
BL6a	-0.755	0.244
BXD01	0.209	0.729
BXD010	0.518	-0.179
BXD011	0.54	0.464
BXD03	0.377	0.45
BXD04	0.524	-0.113
BXD05	-0.354	0.49
BXD06	0.248	0.996
BXD07	0.786	0.223
BXD08	-0.4	-0.564
BXD09	0.622	1.049
CAST	-2.853	-0.976
CCcont	1.016	2.818
DS01	-1.001	-0.216
DS02	-0.129	1.045
DS04	-0.115	0.384
DS0c	-0.826	0.652
GP01	1.52	0.818
GP02	-0.025	0.638
GP0c	1.579	-0.317
NOD	-2.39	-0.099
NZO	0.727	-0.98
PWK	2.552	-0.706
H37Rv_KO_CtpC	0.092	1.212
H37Rv_KO_CtpD	0.235	0.997
H37Rv_KO_Rv1272	0.824	1.863
H37Rv_KO_SugABC	2.212	1.078
H37Rv_KO_MbtN	3.528	0.893
Trans05	1.205	0.393
macrophage_unactivated	-0.514	1.635
IL1	0.703	-0.86
Rapamycin	0.157	0.196
Tcell	-2.346	-0.691
GMCSF	1.31	1.428
IFNab	2.53	1.351
IFNg	0.136	0.492
IFNg_GMCSF1	1.618	0.842
Rv1432_day32	2.092	1.623
Rv1565c_day32	-1.93	0.218
secA2_input	-2.038	-1.027
delta_Rv3594	1.086	0.344
delta_Rv3717	2.536	-0.098
delta_Rv3811	0.828	0.315
delta_Rv0954	-0.282	-1.018
PonA1	-0.912	-0.416
EccD1_KO	-0.109	0.648
EspI_KO	-0.719	0.893
PE35_KO	-1.485	-0.968
PPE68_KO	-0.806	0.266
glycerol2	-0.177	0.254
lignocerate	-0.32	-0.392
oleate	0.457	-0.829
phosphatidylcholine	-0.176	-0.626
acetate	0.0	1.225
glucAc	0.119	0.572
Rv0950ko	-0.615	-5.5
Rv1096ko	0.305	-0.335
Rv3684ko	-0.157	0.783
delta_otsA_trehalose	-0.118	-0.052