TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0497/-:

update plot	correlation	link to info on gene
Rv1836c/-	(cc=0.6274)	info on Rv1836c/-
Rv3854c/ethA	(cc=0.6185)	info on Rv3854c/ethA
Rv1821/secA2	(cc=0.6117)	info on Rv1821/secA2
Rv1111c/-	(cc=0.6082)	info on Rv1111c/-
Rv2190c/-	(cc=0.5803)	info on Rv2190c/-
Rv2696c/-	(cc=0.529)	info on Rv2696c/-
Rv0385/-	(cc=0.5272)	info on Rv0385/-
Rv3207c/-	(cc=0.52)	info on Rv3207c/-
Rv2553c/-	(cc=0.5089)	info on Rv2553c/-
Rv0049/-	(cc=0.4992)	info on Rv0049/-

Correlation of Rv0497/- with Rv0385/-

Normalized LFCs for Rv0497/-:
(description and provenance of datasets)

	Rv0497/-	Rv0385/-
Fe_supp_jason_reseq	2.155	-0.436
low_pH_jason_reseq	-1.887	-1.472
NO_jason_reseq	0.858	-0.824
B6_jason_reseq	-1.375	-0.957
MHCII_jason_reseq	-1.155	-0.264
Isoniazid02	-1.622	-1.873
Rifampicin4	-1.66	-0.856
Ethambutol3	-0.19	-1.837
Meropenem3	-1.154	-1.348
Vancomycin16	-2.555	0.069
Rv2680_day32	1.148	0.735
H37Rv_KO_MarP	-3.88	-4.106
hypoxia_3wks	-1.244	-0.439
hypoxia_6wks	-1.038	1.328
glycerol	-1.24	-0.162
cholesterol	0.748	3.246
AJ	0.487	-0.508
Bibs02	-0.697	-0.225
Bibs02c	-1.773	-0.37
BL6	0.731	0.744
BL6a	-0.755	0.083
BXD01	0.209	0.842
BXD010	0.518	0.005
BXD011	0.54	-0.129
BXD03	0.377	0.494
BXD04	0.524	0.963
BXD05	-0.354	0.632
BXD06	0.248	0.857
BXD07	0.786	0.555
BXD08	-0.4	0.94
BXD09	0.622	0.455
CAST	-2.853	0.475
CCcont	1.016	0.355
DS01	-1.001	0.358
DS02	-0.129	0.091
DS04	-0.115	0.842
DS0c	-0.826	0.542
GP01	1.52	0.71
GP02	-0.025	0.94
GP0c	1.579	0.227
NOD	-2.39	-0.238
NZO	0.727	-0.055
PWK	2.552	1.029
H37Rv_KO_CtpC	0.092	-0.394
H37Rv_KO_CtpD	0.235	-0.139
H37Rv_KO_Rv1272	0.824	-0.64
H37Rv_KO_SugABC	2.212	0.428
H37Rv_KO_MbtN	3.528	1.353
Trans05	1.205	0.584
macrophage_unactivated	-0.514	-0.095
IL1	0.703	-0.231
Rapamycin	0.157	-0.307
Tcell	-2.346	-0.459
GMCSF	1.31	0.33
IFNab	2.53	1.155
IFNg	0.136	0.27
IFNg_GMCSF1	1.618	0.465
Rv1432_day32	2.092	1.352
Rv1565c_day32	-1.93	-3.159
secA2_input	-2.038	-1.141
delta_Rv3594	1.086	-0.425
delta_Rv3717	2.536	0.311
delta_Rv3811	0.828	0.0
delta_Rv0954	-0.282	-0.538
PonA1	-0.912	0.104
EccD1_KO	-0.109	0.224
EspI_KO	-0.719	-0.037
PE35_KO	-1.485	-1.383
PPE68_KO	-0.806	-0.963
glycerol2	-0.177	0.073
lignocerate	-0.32	-0.239
oleate	0.457	-1.418
phosphatidylcholine	-0.176	-1.675
acetate	0.0	0.595
glucAc	0.119	0.166
Rv0950ko	-0.615	0.296
Rv1096ko	0.305	1.113
Rv3684ko	-0.157	0.943
delta_otsA_trehalose	-0.118	-0.144