TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0394c/-:

update plot	correlation	link to info on gene
Rv3812/PE_PGRS62	(cc=0.5205)	info on Rv3812/PE_PGRS62
Rv2882c/frr	(cc=0.5033)	info on Rv2882c/frr
Rv3749c/-	(cc=0.4612)	info on Rv3749c/-
Rv0213c/-	(cc=0.461)	info on Rv0213c/-
Rv0701/rplC	(cc=0.4604)	info on Rv0701/rplC
Rv3673c/-	(cc=0.4545)	info on Rv3673c/-
Rv0741/-	(cc=0.4512)	info on Rv0741/-
Rv0615/-	(cc=0.4489)	info on Rv0615/-
Rv1641/infC	(cc=0.4398)	info on Rv1641/infC
Rv0552/-	(cc=0.4349)	info on Rv0552/-

Correlation of Rv0394c/- with Rv3673c/-

Normalized LFCs for Rv0394c/-:
(description and provenance of datasets)

	Rv0394c/-	Rv3673c/-
Fe_supp_jason_reseq	-0.403	0.0
low_pH_jason_reseq	0.276	0.0
NO_jason_reseq	0.877	0.0
B6_jason_reseq	0.854	0.0
MHCII_jason_reseq	1.06	0.0
Isoniazid02	-0.275	0.0
Rifampicin4	-0.322	0.0
Ethambutol3	-0.816	0.0
Meropenem3	-0.854	0.0
Vancomycin16	-0.348	0.0
Rv2680_day32	0.345	0.0
H37Rv_KO_MarP	0.895	0.0
hypoxia_3wks	0.311	0.0
hypoxia_6wks	0.503	0.0
glycerol	-0.396	0.0
cholesterol	0.226	0.0
AJ	0.121	0.0
Bibs02	0.16	0.0
Bibs02c	0.071	0.0
BL6	0.227	0.0
BL6a	-0.016	0.0
BXD01	-0.337	0.0
BXD010	-0.096	0.0
BXD011	-0.481	0.0
BXD03	0.246	0.0
BXD04	-0.887	0.0
BXD05	0.046	0.0
BXD06	-0.275	0.0
BXD07	-0.027	0.0
BXD08	0.19	0.0
BXD09	-0.427	0.0
CAST	0.637	0.0
CCcont	-0.745	0.0
DS01	-0.178	0.0
DS02	-0.05	0.0
DS04	-0.863	0.0
DS0c	0.25	0.0
GP01	-0.103	0.0
GP02	0.031	0.0
GP0c	-0.932	0.0
NOD	0.737	0.0
NZO	0.14	0.0
PWK	0.095	0.0
H37Rv_KO_CtpC	-0.365	0.0
H37Rv_KO_CtpD	-0.417	0.0
H37Rv_KO_Rv1272	-0.311	0.0
H37Rv_KO_SugABC	0.86	0.0
H37Rv_KO_MbtN	-0.016	0.0
Trans05	-0.814	0.0
macrophage_unactivated	-0.514	0.0
IL1	-1.498	0.0
Rapamycin	-0.945	0.0
Tcell	1.18	0.0
GMCSF	-1.154	0.0
IFNab	-1.484	0.0
IFNg	-0.19	0.0
IFNg_GMCSF1	0.047	0.0
Rv1432_day32	-0.206	0.0
Rv1565c_day32	0.182	0.0
secA2_input	-0.113	0.593
delta_Rv3594	-0.237	0.0
delta_Rv3717	-0.195	0.0
delta_Rv3811	-0.935	0.0
delta_Rv0954	0.012	0.0
PonA1	0.389	0.0
EccD1_KO	-1.22	-1.595
EspI_KO	-1.586	-1.383
PE35_KO	-1.377	-1.415
PPE68_KO	-2.093	-0.71
glycerol2	-0.062	0.0
lignocerate	-0.054	0.0
oleate	-0.259	0.0
phosphatidylcholine	-0.092	0.0
acetate	-0.135	0.0
glucAc	-0.397	0.0
Rv0950ko	0.416	0.0
Rv1096ko	0.63	0.0
Rv3684ko	0.37	0.0
delta_otsA_trehalose	0.038	0.0