TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0373c/-:

update plot	correlation	link to info on gene
Rv0338c/-	(cc=0.7289)	info on Rv0338c/-
Rv2268c/cyp128	(cc=0.6421)	info on Rv2268c/cyp128
Rv1371/-	(cc=0.6126)	info on Rv1371/-
Rv1675c/cmr	(cc=0.5903)	info on Rv1675c/cmr
Rv0669c/-	(cc=0.5499)	info on Rv0669c/-
Rv0320/-	(cc=0.5155)	info on Rv0320/-
Rv1097c/-	(cc=0.4781)	info on Rv1097c/-
Rv2715/-	(cc=0.4709)	info on Rv2715/-
Rv1360/-	(cc=0.4694)	info on Rv1360/-
Rv2090/-	(cc=0.4681)	info on Rv2090/-

Correlation of Rv0373c/- with Rv2715/-

Normalized LFCs for Rv0373c/-:
(description and provenance of datasets)

	Rv0373c/-	Rv2715/-
Fe_supp_jason_reseq	-0.676	-0.508
low_pH_jason_reseq	0.775	0.796
NO_jason_reseq	0.656	-0.646
B6_jason_reseq	-0.535	-0.542
MHCII_jason_reseq	-0.119	0.346
Isoniazid02	-0.31	1.224
Rifampicin4	-0.276	-0.504
Ethambutol3	-0.231	2.932
Meropenem3	1.324	2.498
Vancomycin16	-0.162	0.0
Rv2680_day32	0.836	-0.73
H37Rv_KO_MarP	-0.059	0.223
hypoxia_3wks	0.307	-0.116
hypoxia_6wks	-0.054	0.175
glycerol	0.391	-0.471
cholesterol	5.178	4.799
AJ	-0.261	-0.024
Bibs02	0.126	-0.223
Bibs02c	0.611	1.516
BL6	0.106	0.26
BL6a	0.0	1.24
BXD01	0.213	0.314
BXD010	0.651	1.166
BXD011	0.319	0.642
BXD03	-0.352	0.349
BXD04	-0.163	0.809
BXD05	0.714	0.369
BXD06	-0.098	0.366
BXD07	-0.269	0.357
BXD08	-0.149	0.448
BXD09	-0.158	0.788
CAST	0.195	-0.28
CCcont	0.151	0.348
DS01	-0.086	0.429
DS02	-0.039	0.132
DS04	0.067	0.682
DS0c	0.633	0.046
GP01	0.017	0.804
GP02	1.31	0.516
GP0c	0.543	0.387
NOD	0.19	1.787
NZO	0.069	-0.964
PWK	0.82	0.158
H37Rv_KO_CtpC	-0.577	0.607
H37Rv_KO_CtpD	0.559	0.185
H37Rv_KO_Rv1272	0.252	0.558
H37Rv_KO_SugABC	0.471	0.898
H37Rv_KO_MbtN	-0.502	1.101
Trans05	0.515	1.278
macrophage_unactivated	0.357	0.3
IL1	-0.27	-0.065
Rapamycin	0.512	0.353
Tcell	-0.196	0.176
GMCSF	0.298	-0.148
IFNab	0.175	-0.133
IFNg	0.446	0.644
IFNg_GMCSF1	-0.386	-0.358
Rv1432_day32	-0.505	-0.499
Rv1565c_day32	0.58	-0.655
secA2_input	-0.348	-0.11
delta_Rv3594	0.567	0.728
delta_Rv3717	0.0	0.151
delta_Rv3811	0.0	1.169
delta_Rv0954	-0.168	0.783
PonA1	-0.422	0.386
EccD1_KO	-0.253	1.095
EspI_KO	-0.451	0.95
PE35_KO	-0.648	1.476
PPE68_KO	-0.573	0.784
glycerol2	-0.171	-0.476
lignocerate	-0.149	0.102
oleate	-0.085	-0.216
phosphatidylcholine	-0.028	0.0
acetate	0.304	0.206
glucAc	0.059	0.481
Rv0950ko	-0.338	-0.109
Rv1096ko	0.374	-0.145
Rv3684ko	0.468	-0.318
delta_otsA_trehalose	-1.609	0.879