TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0373c/-:

update plot	correlation	link to info on gene
Rv0338c/-	(cc=0.7289)	info on Rv0338c/-
Rv2268c/cyp128	(cc=0.6421)	info on Rv2268c/cyp128
Rv1371/-	(cc=0.6126)	info on Rv1371/-
Rv1675c/cmr	(cc=0.5903)	info on Rv1675c/cmr
Rv0669c/-	(cc=0.5499)	info on Rv0669c/-
Rv0320/-	(cc=0.5155)	info on Rv0320/-
Rv1097c/-	(cc=0.4781)	info on Rv1097c/-
Rv2715/-	(cc=0.4709)	info on Rv2715/-
Rv1360/-	(cc=0.4694)	info on Rv1360/-
Rv2090/-	(cc=0.4681)	info on Rv2090/-

Correlation of Rv0373c/- with Rv1097c/-

Normalized LFCs for Rv0373c/-:
(description and provenance of datasets)

	Rv0373c/-	Rv1097c/-
Fe_supp_jason_reseq	-0.676	-1.111
low_pH_jason_reseq	0.775	-0.915
NO_jason_reseq	0.656	0.257
B6_jason_reseq	-0.535	-0.489
MHCII_jason_reseq	-0.119	-1.162
Isoniazid02	-0.31	0.026
Rifampicin4	-0.276	0.728
Ethambutol3	-0.231	0.522
Meropenem3	1.324	0.829
Vancomycin16	-0.162	-0.151
Rv2680_day32	0.836	0.713
H37Rv_KO_MarP	-0.059	0.272
hypoxia_3wks	0.307	-0.291
hypoxia_6wks	-0.054	0.372
glycerol	0.391	-0.298
cholesterol	5.178	3.367
AJ	-0.261	-0.508
Bibs02	0.126	0.07
Bibs02c	0.611	0.041
BL6	0.106	-0.835
BL6a	0.0	0.291
BXD01	0.213	0.025
BXD010	0.651	0.166
BXD011	0.319	0.312
BXD03	-0.352	0.244
BXD04	-0.163	0.202
BXD05	0.714	0.68
BXD06	-0.098	0.77
BXD07	-0.269	0.155
BXD08	-0.149	0.076
BXD09	-0.158	0.794
CAST	0.195	0.045
CCcont	0.151	-0.091
DS01	-0.086	0.578
DS02	-0.039	0.083
DS04	0.067	0.0
DS0c	0.633	-0.225
GP01	0.017	0.546
GP02	1.31	1.896
GP0c	0.543	0.807
NOD	0.19	-1.336
NZO	0.069	0.114
PWK	0.82	-0.851
H37Rv_KO_CtpC	-0.577	0.448
H37Rv_KO_CtpD	0.559	-1.049
H37Rv_KO_Rv1272	0.252	-0.086
H37Rv_KO_SugABC	0.471	-0.241
H37Rv_KO_MbtN	-0.502	0.582
Trans05	0.515	0.811
macrophage_unactivated	0.357	2.273
IL1	-0.27	1.293
Rapamycin	0.512	0.433
Tcell	-0.196	-0.068
GMCSF	0.298	0.322
IFNab	0.175	1.366
IFNg	0.446	0.326
IFNg_GMCSF1	-0.386	-0.066
Rv1432_day32	-0.505	0.321
Rv1565c_day32	0.58	0.738
secA2_input	-0.348	-0.679
delta_Rv3594	0.567	0.974
delta_Rv3717	0.0	0.999
delta_Rv3811	0.0	0.183
delta_Rv0954	-0.168	0.041
PonA1	-0.422	0.937
EccD1_KO	-0.253	0.395
EspI_KO	-0.451	-0.473
PE35_KO	-0.648	0.828
PPE68_KO	-0.573	0.653
glycerol2	-0.171	-0.115
lignocerate	-0.149	-0.066
oleate	-0.085	-0.328
phosphatidylcholine	-0.028	-0.324
acetate	0.304	-0.332
glucAc	0.059	0.858
Rv0950ko	-0.338	-0.253
Rv1096ko	0.374	2.763
Rv3684ko	0.468	1.579
delta_otsA_trehalose	-1.609	-1.211