TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0184/-:

update plot	correlation	link to info on gene
Rv3922c/-	(cc=0.5587)	info on Rv3922c/-
Rv3770B/-	(cc=0.5035)	info on Rv3770B/-
Rv0309/-	(cc=0.4897)	info on Rv0309/-
Rv0821c/phoY2	(cc=0.4753)	info on Rv0821c/phoY2
Rv2179c/-	(cc=0.4613)	info on Rv2179c/-
Rv0905/echA6	(cc=0.4519)	info on Rv0905/echA6
Rv2731/-	(cc=0.4471)	info on Rv2731/-
Rv1712/cmk	(cc=0.4354)	info on Rv1712/cmk
Rv0179c/lprO	(cc=0.4326)	info on Rv0179c/lprO
Rv3719/-	(cc=0.4322)	info on Rv3719/-

Correlation of Rv0184/- with Rv2731/-

Normalized LFCs for Rv0184/-:
(description and provenance of datasets)

	Rv0184/-	Rv2731/-
Fe_supp_jason_reseq	-0.481	-2.379
low_pH_jason_reseq	0.468	-0.194
NO_jason_reseq	0.425	0.066
B6_jason_reseq	-0.988	0.758
MHCII_jason_reseq	-0.623	-1.473
Isoniazid02	0.269	1.493
Rifampicin4	-0.639	-1.14
Ethambutol3	1.13	0.062
Meropenem3	1.313	-0.108
Vancomycin16	-0.881	-0.764
Rv2680_day32	0.849	2.646
H37Rv_KO_MarP	0.502	0.384
hypoxia_3wks	-1.017	-0.351
hypoxia_6wks	-0.666	-0.952
glycerol	1.448	1.807
cholesterol	0.083	1.207
AJ	-0.176	-1.104
Bibs02	1.351	0.91
Bibs02c	0.835	-0.255
BL6	0.719	1.916
BL6a	1.376	1.291
BXD01	1.114	1.932
BXD010	1.26	1.92
BXD011	1.352	1.774
BXD03	0.919	0.068
BXD04	1.05	1.641
BXD05	0.715	0.083
BXD06	1.159	1.331
BXD07	1.212	2.091
BXD08	1.846	2.942
BXD09	0.932	1.316
CAST	2.087	0.686
CCcont	0.487	1.304
DS01	1.234	-0.69
DS02	0.996	0.709
DS04	0.436	0.614
DS0c	0.435	1.975
GP01	0.0	1.64
GP02	0.42	2.305
GP0c	0.942	2.616
NOD	0.28	-1.461
NZO	0.376	0.828
PWK	0.32	0.0
H37Rv_KO_CtpC	-0.149	1.418
H37Rv_KO_CtpD	-0.793	0.208
H37Rv_KO_Rv1272	0.23	0.985
H37Rv_KO_SugABC	1.122	-0.911
H37Rv_KO_MbtN	1.02	1.979
Trans05	1.461	2.191
macrophage_unactivated	0.562	-1.61
IL1	1.382	-0.43
Rapamycin	0.902	-0.528
Tcell	1.476	0.332
GMCSF	1.605	-1.938
IFNab	0.396	-0.493
IFNg	0.35	-0.535
IFNg_GMCSF1	1.54	0.126
Rv1432_day32	0.926	1.802
Rv1565c_day32	0.049	-0.602
secA2_input	-0.08	0.454
delta_Rv3594	0.061	0.093
delta_Rv3717	0.099	2.139
delta_Rv3811	0.309	0.534
delta_Rv0954	-1.07	-0.105
PonA1	0.27	-0.553
EccD1_KO	0.237	0.428
EspI_KO	-0.034	-0.2
PE35_KO	-0.257	-0.551
PPE68_KO	0.483	0.573
glycerol2	-0.132	-0.383
lignocerate	-0.095	-2.325
oleate	0.224	-1.007
phosphatidylcholine	-0.373	-2.844
acetate	-0.239	-0.07
glucAc	0.149	0.622
Rv0950ko	0.832	1.83
Rv1096ko	1.028	0.962
Rv3684ko	2.351	1.634
delta_otsA_trehalose	-0.57	-1.881