TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0180c/-:

update plot	correlation	link to info on gene
Rv3283/sseA	(cc=0.7268)	info on Rv3283/sseA
Rv0411c/glnH	(cc=0.7034)	info on Rv0411c/glnH
Rv2844/-	(cc=0.6519)	info on Rv2844/-
Rv0410c/pknG	(cc=0.6418)	info on Rv0410c/pknG
Rv0412c/-	(cc=0.623)	info on Rv0412c/-
Rv2130c/mshC	(cc=0.5752)	info on Rv2130c/mshC
Rv1388/mihF	(cc=0.5682)	info on Rv1388/mihF
Rv1436/gap	(cc=0.5482)	info on Rv1436/gap
Rv1002c/-	(cc=0.5434)	info on Rv1002c/-
Rv2507/-	(cc=0.5377)	info on Rv2507/-

Correlation of Rv0180c/- with Rv1388/mihF

Normalized LFCs for Rv0180c/-:
(description and provenance of datasets)

	Rv0180c/-	Rv1388/mihF
Fe_supp_jason_reseq	1.796	0.0
low_pH_jason_reseq	0.0	0.44
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	-1.101	-0.16
Rifampicin4	-2.762	-1.933
Ethambutol3	-0.761	-0.733
Meropenem3	-2.105	-0.926
Vancomycin16	-1.499	0.44
Rv2680_day32	0.0	-0.459
H37Rv_KO_MarP	-3.151	0.086
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	4.308	0.0
cholesterol	3.09	0.58
AJ	0.0	-0.541
Bibs02	0.0	0.0
Bibs02c	0.735	1.441
BL6	0.0	-0.53
BL6a	0.0	0.26
BXD01	0.0	-0.552
BXD010	0.0	-0.543
BXD011	0.0	-0.54
BXD03	0.0	-0.573
BXD04	0.0	-0.524
BXD05	0.0	-0.57
BXD06	0.0	-0.566
BXD07	0.0	-0.587
BXD08	0.0	-0.564
BXD09	0.0	-0.596
CAST	0.439	-0.976
CCcont	0.0	-0.633
DS01	3.713	1.16
DS02	0.597	0.537
DS04	0.533	-0.822
DS0c	1.788	-0.702
GP01	0.0	-0.418
GP02	0.0	-0.353
GP0c	0.0	-0.551
NOD	0.952	-0.952
NZO	0.0	0.0
PWK	0.0	-0.831
H37Rv_KO_CtpC	0.162	-0.688
H37Rv_KO_CtpD	0.0	-0.092
H37Rv_KO_Rv1272	0.0	-0.598
H37Rv_KO_SugABC	0.0	-0.42
H37Rv_KO_MbtN	0.283	-0.437
Trans05	0.0	-0.554
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	-1.207
Rv1565c_day32	0.0	0.0
secA2_input	-0.221	-0.047
delta_Rv3594	-0.211	0.895
delta_Rv3717	-0.174	0.0
delta_Rv3811	-0.205	0.205
delta_Rv0954	0.163	0.627
PonA1	2.587	3.038
EccD1_KO	0.0	-0.243
EspI_KO	0.0	-0.433
PE35_KO	5.507	2.354
PPE68_KO	3.846	2.451
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	-2.831	-1.987
Rv1096ko	0.856	-1.764
Rv3684ko	1.254	-0.861
delta_otsA_trehalose	-0.34	0.564