TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0131c/fadE1:

update plot	correlation	link to info on gene
Rv1598c/-	(cc=0.5109)	info on Rv1598c/-
Rv2970A/-	(cc=0.4673)	info on Rv2970A/-
Rv2330c/lppP	(cc=0.4658)	info on Rv2330c/lppP
Rv0804/-	(cc=0.4569)	info on Rv0804/-
Rv3153/nuoI	(cc=0.4555)	info on Rv3153/nuoI
Rv1471/trxB1	(cc=0.4552)	info on Rv1471/trxB1
Rv3146/nuoB	(cc=0.4506)	info on Rv3146/nuoB
Rv1831/-	(cc=0.4461)	info on Rv1831/-
Rv0844c/narL	(cc=0.4298)	info on Rv0844c/narL
Rv2852c/mqo	(cc=0.4238)	info on Rv2852c/mqo

Correlation of Rv0131c/fadE1 with Rv0804/-

Normalized LFCs for Rv0131c/fadE1:
(description and provenance of datasets)

	Rv0131c/fadE1	Rv0804/-
Fe_supp_jason_reseq	-0.808	-2.502
low_pH_jason_reseq	0.592	1.019
NO_jason_reseq	-0.457	-0.42
B6_jason_reseq	-0.523	1.095
MHCII_jason_reseq	-0.06	-0.108
Isoniazid02	0.081	-0.39
Rifampicin4	-0.525	-0.149
Ethambutol3	0.582	-0.137
Meropenem3	-0.448	0.032
Vancomycin16	-0.186	0.377
Rv2680_day32	0.885	1.871
H37Rv_KO_MarP	0.021	0.109
hypoxia_3wks	0.0	1.575
hypoxia_6wks	1.128	2.007
glycerol	0.743	0.897
cholesterol	-0.018	0.069
AJ	-0.059	-0.805
Bibs02	-0.497	0.172
Bibs02c	0.576	-0.409
BL6	0.99	0.694
BL6a	0.323	0.274
BXD01	0.432	0.578
BXD010	1.21	0.516
BXD011	0.938	0.414
BXD03	1.038	0.584
BXD04	0.375	0.28
BXD05	0.37	0.284
BXD06	0.538	0.213
BXD07	1.294	0.842
BXD08	0.747	0.988
BXD09	1.129	0.418
CAST	0.375	-0.417
CCcont	0.425	-0.544
DS01	-0.25	-0.392
DS02	-0.23	-0.195
DS04	-1.152	0.715
DS0c	0.053	-0.225
GP01	-0.352	-1.756
GP02	-0.161	-1.818
GP0c	-1.174	-1.077
NOD	-0.238	-0.76
NZO	0.429	-0.126
PWK	-0.566	-0.099
H37Rv_KO_CtpC	0.462	-0.884
H37Rv_KO_CtpD	0.757	-0.375
H37Rv_KO_Rv1272	1.012	-0.407
H37Rv_KO_SugABC	0.813	0.137
H37Rv_KO_MbtN	0.834	0.316
Trans05	0.36	0.282
macrophage_unactivated	-0.767	-1.588
IL1	0.196	0.537
Rapamycin	0.203	-0.371
Tcell	-0.665	-0.45
GMCSF	0.116	-0.341
IFNab	-0.136	0.07
IFNg	0.176	-0.021
IFNg_GMCSF1	1.251	0.327
Rv1432_day32	0.588	1.16
Rv1565c_day32	-0.319	-1.749
secA2_input	1.066	0.368
delta_Rv3594	-0.595	-0.84
delta_Rv3717	-0.05	0.609
delta_Rv3811	-0.455	-0.538
delta_Rv0954	-0.817	-1.107
PonA1	0.516	-1.146
EccD1_KO	0.506	0.724
EspI_KO	0.833	0.876
PE35_KO	0.656	0.242
PPE68_KO	0.582	0.208
glycerol2	1.442	-0.032
lignocerate	0.17	-0.555
oleate	0.815	1.46
phosphatidylcholine	0.475	-0.294
acetate	0.856	0.575
glucAc	0.398	-1.382
Rv0950ko	0.0	0.519
Rv1096ko	0.374	0.688
Rv3684ko	0.357	0.147
delta_otsA_trehalose	-1.683	0.17