TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0131c/fadE1:

update plot	correlation	link to info on gene
Rv1598c/-	(cc=0.5109)	info on Rv1598c/-
Rv2970A/-	(cc=0.4673)	info on Rv2970A/-
Rv2330c/lppP	(cc=0.4658)	info on Rv2330c/lppP
Rv0804/-	(cc=0.4569)	info on Rv0804/-
Rv3153/nuoI	(cc=0.4555)	info on Rv3153/nuoI
Rv1471/trxB1	(cc=0.4552)	info on Rv1471/trxB1
Rv3146/nuoB	(cc=0.4506)	info on Rv3146/nuoB
Rv1831/-	(cc=0.4461)	info on Rv1831/-
Rv0844c/narL	(cc=0.4298)	info on Rv0844c/narL
Rv2852c/mqo	(cc=0.4238)	info on Rv2852c/mqo

Correlation of Rv0131c/fadE1 with Rv1598c/-

Normalized LFCs for Rv0131c/fadE1:
(description and provenance of datasets)

	Rv0131c/fadE1	Rv1598c/-
Fe_supp_jason_reseq	-0.808	-0.101
low_pH_jason_reseq	0.592	-0.43
NO_jason_reseq	-0.457	-0.57
B6_jason_reseq	-0.523	-2.25
MHCII_jason_reseq	-0.06	-1.365
Isoniazid02	0.081	0.898
Rifampicin4	-0.525	0.057
Ethambutol3	0.582	0.026
Meropenem3	-0.448	-0.277
Vancomycin16	-0.186	0.454
Rv2680_day32	0.885	0.78
H37Rv_KO_MarP	0.021	-0.257
hypoxia_3wks	0.0	-0.658
hypoxia_6wks	1.128	0.752
glycerol	0.743	0.929
cholesterol	-0.018	0.624
AJ	-0.059	-0.392
Bibs02	-0.497	0.156
Bibs02c	0.576	-0.676
BL6	0.99	1.5
BL6a	0.323	-0.09
BXD01	0.432	0.571
BXD010	1.21	1.393
BXD011	0.938	1.554
BXD03	1.038	0.357
BXD04	0.375	-0.79
BXD05	0.37	0.195
BXD06	0.538	0.155
BXD07	1.294	0.045
BXD08	0.747	0.523
BXD09	1.129	-0.165
CAST	0.375	0.587
CCcont	0.425	0.61
DS01	-0.25	0.128
DS02	-0.23	-0.703
DS04	-1.152	0.146
DS0c	0.053	-0.453
GP01	-0.352	0.226
GP02	-0.161	-1.152
GP0c	-1.174	0.765
NOD	-0.238	-0.076
NZO	0.429	-1.49
PWK	-0.566	-0.547
H37Rv_KO_CtpC	0.462	-0.171
H37Rv_KO_CtpD	0.757	1.076
H37Rv_KO_Rv1272	1.012	1.206
H37Rv_KO_SugABC	0.813	0.894
H37Rv_KO_MbtN	0.834	1.943
Trans05	0.36	1.179
macrophage_unactivated	-0.767	0.249
IL1	0.196	0.068
Rapamycin	0.203	-0.611
Tcell	-0.665	-0.114
GMCSF	0.116	0.121
IFNab	-0.136	-0.142
IFNg	0.176	-0.428
IFNg_GMCSF1	1.251	-0.148
Rv1432_day32	0.588	0.566
Rv1565c_day32	-0.319	0.163
secA2_input	1.066	1.295
delta_Rv3594	-0.595	-1.872
delta_Rv3717	-0.05	-0.799
delta_Rv3811	-0.455	-1.224
delta_Rv0954	-0.817	-1.976
PonA1	0.516	-0.998
EccD1_KO	0.506	0.043
EspI_KO	0.833	1.146
PE35_KO	0.656	1.4
PPE68_KO	0.582	0.669
glycerol2	1.442	0.07
lignocerate	0.17	0.36
oleate	0.815	0.449
phosphatidylcholine	0.475	0.265
acetate	0.856	0.424
glucAc	0.398	-0.403
Rv0950ko	0.0	0.531
Rv1096ko	0.374	0.0
Rv3684ko	0.357	-0.072
delta_otsA_trehalose	-1.683	-1.62