TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3672c/-:
Show top 50 genes. Show bottom 10 genes with LOWEST correlation.

Most correlated genes.

update plot	correlation	link to info on gene
Rv2525c/-	(cc=0.4996)	info on Rv2525c/-
Rv0111/-	(cc=0.4815)	info on Rv0111/-
Rv3330/dacB1	(cc=0.4745)	info on Rv3330/dacB1
Rv0999/-	(cc=0.4721)	info on Rv0999/-
Rv2594c/ruvC	(cc=0.4683)	info on Rv2594c/ruvC
Rv0129c/fbpC	(cc=0.4651)	info on Rv0129c/fbpC
Rv0231/fadE4	(cc=0.4649)	info on Rv0231/fadE4
Rv0937c/mku	(cc=0.4262)	info on Rv0937c/mku
Rv3267/-	(cc=0.4232)	info on Rv3267/-
Rv0500A/-	(cc=0.4231)	info on Rv0500A/-

Correlation of Rv3672c/- with Rv2525c/-

Normalized LFCs for Rv3672c/-:
(description and provenance of datasets)

Comparison of LFCs between selected condtions.

condition	Rv3672c/-	Rv2525c/-
Fe_supp_jason_reseq	0.991	0.016
low_pH_jason_reseq	-1.601	-1.698
NO_jason_reseq	-0.761	-0.362
B6_jason_reseq	-0.206	-1.161
MHCII_jason_reseq	-0.088	-0.859
Isoniazid02	-0.733	0.771
Rifampicin4	-4.164	-6.0
Ethambutol3	-2.047	-0.255
Meropenem3	-1.612	-3.837
Vancomycin16	-2.125	-3.658
Rv2680_day32	-1.553	-1.177
H37Rv_KO_MarP	-0.412	-0.412
hypoxia_3wks	1.719	-0.498
hypoxia_6wks	-0.347	-0.424
glycerol	0.976	-0.405
cholesterol	-0.156	0.509
AJ	0.513	-1.044
Bibs02	-1.991	0.301
Bibs02c	-0.702	0.086
BL6	0.668	-0.258
BL6a	-0.306	-0.247
BXD01	-0.866	-1.396
BXD010	0.847	-0.272
BXD011	1.964	-0.658
BXD03	1.312	-0.241
BXD04	-0.563	-0.461
BXD05	0.767	-0.366
BXD06	-0.338	-0.428
BXD07	-0.058	-0.41
BXD08	-0.028	-0.462
BXD09	0.465	0.083
CAST	-0.302	-1.245
CCcont	1.2	0.246
DS01	1.203	0.077
DS02	-0.61	-0.258
DS04	-0.544	-1.033
DS0c	-1.442	0.347
GP01	2.222	0.774
GP02	-0.521	-0.251
GP0c	0.449	0.864
NOD	-0.513	0.862
NZO	-0.455	-0.799
PWK	-0.35	-1.707
H37Rv_KO_CtpC	-1.352	0.368
H37Rv_KO_CtpD	-1.174	-0.561
H37Rv_KO_Rv1272	0.718	-1.197
H37Rv_KO_SugABC	-1.588	-0.257
H37Rv_KO_MbtN	-1.248	-0.977
Trans05	-0.401	-0.339
macrophage_unactivated	0.369	0.597
IL1	-1.353	0.917
Rapamycin	0.221	0.169
Tcell	0.668	0.469
GMCSF	1.814	0.222
IFNab	1.938	0.423
IFNg	0.767	0.107
IFNg_GMCSF1	1.863	-0.047
Rv1432_day32	0.0	-1.24
Rv1565c_day32	0.0	-1.178
secA2_input	0.133	0.712
delta_Rv3594	0.278	-0.574
delta_Rv3717	0.474	-0.019
delta_Rv3811	-0.201	-1.114
delta_Rv0954	0.283	-0.283
PonA1	0.971	0.275
EccD1_KO	-0.345	-0.483
EspI_KO	-0.767	-0.433
PE35_KO	-0.537	-1.044
PPE68_KO	-0.806	-0.822
glycerol2	-1.297	-0.174
lignocerate	-0.666	-0.486
oleate	-0.417	-0.537
phosphatidylcholine	-0.618	-0.391
acetate	-0.198	0.166
glucAc	0.076	-0.211
Rv0950ko	-0.781	0.588
Rv1096ko	0.419	1.013
Rv3684ko	0.871	0.508
delta_otsA_trehalose	1.708	-0.259