Rv2594c (ruvC)

Current annotations:
- TBCAP: (community-based annotations - see table at bottom of page)
- TBDB: crossover junction endodeoxyribonuclease ruvC
- REFSEQ: Holliday junction resolvase
- PATRIC: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)
- TUBERCULIST: Probable crossover junction endodeoxyribonuclease RuvC (holliday junction nuclease) (holliday junction resolvase)
- NCBI: Probable crossover junction endodeoxyribonuclease RuvC (holliday junction nuclease) (holliday junction resolvase)
- updated information (H37Rv4):
  - gene name: ruvC
  - function:
  - reference:
Type: Not Target
Start: 2924817
End: 2925383
Operon:

Trans-membrane region:
Role: II.A.5 - DNA replication, repair, recombination and restriction/modification
GO terms:
- GO:0090305 - nucleic acid phosphodiester bond hydrolysis (Uniprot)
- GO:0071932 - replication fork reversal (Uniprot)
- GO:0048476 - Holliday junction resolvase complex (Uniprot)
- GO:0046872 - metal ion binding (Uniprot)
- GO:0016787 - hydrolase activity (Uniprot)
- GO:0009432 - SOS response (Uniprot)
- GO:0008821 - crossover junction endodeoxyribonuclease activity (Uniprot)
- GO:0006974 - cellular response to DNA damage stimulus (Uniprot)
- GO:0006310 - DNA recombination (Uniprot)
- GO:0006281 - DNA repair (Uniprot)
- GO:0004520 - endodeoxyribonuclease activity (Uniprot)
- GO:0004518 - nuclease activity (Uniprot)
- GO:0003676 - nucleic acid binding (Uniprot)
- GO:0000725 - recombinational repair (Uniprot)
Reaction(s) (based on iSM810 metabolic model):
Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
Orthologs among selected mycobacteria
Protein structure:
Search for Homologs in PDB

Top 10 Homologs in PDB (as of Nov 2020):

PDB	aa ident	species	PDB title
1HJR	40%	Escherichia coli	ATOMIC STRUCTURE OF THE RUVC RESOLVASE: A HOLLIDAY JUNCTION-SPECIFIC ENDONUCLEASE FROM E. COLI
6LW3	38%	Pseudomonas aeruginosa	Crystal structure of RuvC from Pseudomonas aeruginosa
6S16	35%	Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)	T. thermophilus RuvC in complex with Holliday junction substrate
4EP4	35%	Thermus thermophilus	Thermus thermophilus RuvC structure

Links to additional information on ruvC:
- TBDB (updated)
- Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
- UniProt
- AlphaFold model
- Vulnerability = -3.115 (from Jeremy Rock's lab)
- KEGG - nucleotide and amino acid sequences of gene
- Mycobrowser
- PATRIC
- BioCyc
- Systems Biology

Amino Acid Sequence

VRVMGVDPGLTRCGLSLIESGRGRQLTALDVDVVRTPSDAALAQRLLAISDAVEHWLDTHHPEVVAIERVFSQLNVTTVMGTAQAGGVIALAAAKRGVDV
HFHTPSEVKAAVTGNGSADKAQVTAMVTKILALQAKPTPADAADALALAICHCWRAPTIARMAEATSRAEARAAQQRHAYLAKLKAAR

(Nucleotide sequence available on KEGG)

Additional Information

ESSENTIALITY

MtbTnDB - interactive tool for exploring a database of published TnSeq datasets for Mtb

TnSeqCorr - genes with correlated TnSeq profiles across >100 conditions *new*

Classification	Condition	Strain	Method	Reference	Notes
Uncertain	Sodium Oleate	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.896550; 6 non-insertions in a row out of 6 sites
Uncertain	Lignoceric Acid	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.972200; 6 non-insertions in a row out of 6 sites
Uncertain	Phosphatidylcholine	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.975800; 6 non-insertions in a row out of 6 sites
Uncertain	minimal media + 0.1% glycerol	H37RvMA	Gumbel	Griffin et al. (2011)	Probability of Essentiality: 0.965400; 6 non-insertions in a row out of 6 sites
Uncertain	minimal media + 0.01% cholesterol	H37RvMA	Gumbel	Griffin et al. (2011)	Probability of Essentiality: 0.962000; 6 non-insertions in a row out of 6 sites
No-Data	7H10-glycerol	H37RvMA	TraSH	Sassetti et al. (2003a)
Too-Short	C57BL/6J mice (8 weeks)	H37RvMA	TraSH	Sassetti et al. (2003b)	Hybridization Ratio: -1
Growth-Defect	7H09/7H10 + rich media	H37RvMA	MotifHMM	DeJesus et al. (2017)	Fully saturated (14 reps).

TnSeq Data No data currently available.

No TnSeq data currently available for this Target.

RNASeq Data No data currently available.

No RNA-Seq data currently available for this Target.

Metabolomic Profiles No data currently available.

No Metabolomic data currently available for this Target.

Proteomic Data No data currently available.

No Proteomic data currently available for this Target.

Regulatory Relationships from Systems Biology

BioCyc

Gene interactions based on ChIPSeq and Transcription Factor Over-Expression (TFOE) (Systems Biology)

NOTE: Green edges represent the connected genes being classified as differentially essential as a result of the middle gene being knocked out. These interactions are inferred based on RNASeq.

Interactions based on ChIPSeq data

Binds To:
- No bindings to other targets were found.
Bound By:

Interactions based on ChIPSeq data (Minch et al. 2014)

Binds To:
- No bindings to other targets were found.
Bound By:
- Rv0081 (-) (Direct binding)
- Rv1423 (whiA) (Direct binding)
- Rv3736 (-) (Direct binding)

Interactions based on TFOE data (Rustad et al. 2014)

Upregulates:
- Does not upregulate other genes.
Upregulated by:
- Not upregulated by other genes.
Downregulates:
- Does not downregulate other genes.
Downregulated by:

TBCAP

Tubculosis Community Annotation Project (

Slayden et al., 2013

Rv2594c (ruvC)

Property	Value	Creator	Evidence	PMID	Comment
Interaction	PhysicalInteraction Rv2973c	shahanup86	ISS		Structural Analysis D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003
Interaction	PhysicalInteraction Rv2973c	shahanup86	ISS		Structural Analysis authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000
Interaction	PhysicalInteraction Rv2973c	shahanup86	ISS		Structural Analysis authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004
Interaction	PhysicalInteraction Rv2973c	shahanup86	ISS		Structural Analysis authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001
Interaction	PhysicalInteraction Rv2973c	shahanup86	ISS		Structural Analysis authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002
Interaction	PhysicalInteraction Rv2973c	shahanup86	ISS		Structural Analysis authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999
Interaction	PhysicalInteraction Rv2973c	shahanup86	ISS		Spectrophotometric D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003
Interaction	PhysicalInteraction Rv2973c	shahanup86	ISS		Spectrophotometric authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000
Interaction	PhysicalInteraction Rv2973c	shahanup86	ISS		Spectrophotometric authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002
Interaction	PhysicalInteraction Rv2973c	shahanup86	ISS		Spectrophotometric authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004
Interaction	PhysicalInteraction Rv2973c	shahanup86	ISS		Spectrophotometric authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001
Interaction	PhysicalInteraction Rv2973c	shahanup86	ISS		Spectrophotometric authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999
Interaction	PhysicalInteraction Rv2603c	sureshks89	ISA		authors,MY. Galperin,EV. Koonin From complete genome sequence to 'complete' understanding? Trends Biotechnol. 2010
Interaction	PhysicalInteraction Rv2603c	sureshks89	ISA		authors,H. Liang,L. Li,Z. Dong,MG. Surette,K. Duan The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production. J. Bacteriol. 2008
Citation	Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. PC. Brooks, F. Movahedzadeh et al. J. Bacteriol. 2001	shahanup86	IEP	11443079	Co-expression (Functional linkage)
Interaction	PhysicalInteraction Rv2592c	shahanup86	IEP		Co-expression (Functional linkage) PC. Brooks, F. Movahedzadeh et al. Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. J. Bacteriol. 2001
Interaction	PhysicalInteraction Rv2593c	shahanup86	IEP		Co-expression (Functional linkage) PC. Brooks, F. Movahedzadeh et al. Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. J. Bacteriol. 2001
Citation	Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. JR. Prabu, S. Thamotharan et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006	shahanup86	IEP	16880543	Co-expression (Functional linkage)
Interaction	PhysicalInteraction Rv2592c	shahanup86	IEP		Co-expression (Functional linkage) JR. Prabu, S. Thamotharan et al. Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006
Interaction	PhysicalInteraction Rv2593c	shahanup86	IEP		Co-expression (Functional linkage) JR. Prabu, S. Thamotharan et al. Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006
Citation	Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. PC. Brooks, F. Movahedzadeh et al. J. Bacteriol. 2001	shahanup86	IEP	11443079	Co-expression (Functional linkage)
Interaction	PhysicalInteraction Rv2592c	shahanup86	IEP		Co-expression (Functional linkage) PC. Brooks, F. Movahedzadeh et al. Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. J. Bacteriol. 2001
Interaction	PhysicalInteraction Rv2593c	shahanup86	IEP		Co-expression (Functional linkage) PC. Brooks, F. Movahedzadeh et al. Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. J. Bacteriol. 2001
Citation	Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. JR. Prabu, S. Thamotharan et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006	shahanup86	IEP	16880543	Co-expression (Functional linkage)
Interaction	PhysicalInteraction Rv2592c	shahanup86	IEP		Co-expression (Functional linkage) JR. Prabu, S. Thamotharan et al. Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006
Interaction	PhysicalInteraction Rv2593c	shahanup86	IEP		Co-expression (Functional linkage) JR. Prabu, S. Thamotharan et al. Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006
Interaction	PhysicalInteraction Rv2593c	shahanup86	IDA		Structural Analysis JR. Prabu, S. Thamotharan et al. Crystallographic and modelling studies on Mycobacterium tuberculosis RuvA Additional role of RuvB-binding domain and inter species variability. Biochim. Biophys. Acta 2009
Interaction	PhysicalInteraction Rv2593c	shahanup86	IDA		Structural Analysis JS. Khanduja, P. Tripathi et al. Mycobacterium tuberculosis RuvA Induces Two Distinct Types of Structural Distortions between the Homologous and Heterologous Holliday Junctions (dagger). Biochemistry 2008
Interaction	PhysicalInteraction Rv2593c	shahanup86	IDA		Structural Analysis authors,CV. Privezentzev,A. Keeley,B. Sigala,IR. Tsaneva The role of RuvA octamerization for RuvAB function in vitro and in vivo. J. Biol. Chem. 2005
Interaction	PhysicalInteraction Rv2593c	shahanup86	IDA		Structural Analysis JR. Prabu, S. Thamotharan et al. Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006
Interaction	PhysicalInteraction Rv2593c	shahanup86	IDA		Structural Analysis PC. Brooks, F. Movahedzadeh et al. Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. J. Bacteriol. 2001
Interaction	Regulatory Rv0616c	akankshajain.21	IEP		Co-expression (Functional linkage) T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
Interaction	RegulatedBy Rv2720	yamir.moreno	TAS		Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support. G. Balzsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008
Interaction	RegulatedBy Rv0491	yamir.moreno	IEP		Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003
Other	TBPWY:Recombination repair	vmizrahi			recA-independent DNA damage-induced
Other	TBPWY:Recombination repair	vmizrahi			Increased expression in Mtb from clinical lung samples

Property

Value

Creator

Evidence

PMID

Comment

Interaction

PhysicalInteraction Rv2973c

shahanup86

ISS

Structural Analysis
D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003

Interaction

PhysicalInteraction Rv2973c

shahanup86

ISS

Structural Analysis
authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000

Interaction

PhysicalInteraction Rv2973c

shahanup86

ISS

Structural Analysis
authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004

Interaction

PhysicalInteraction Rv2973c

shahanup86

ISS

Structural Analysis
authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001

Interaction

PhysicalInteraction Rv2973c

shahanup86

ISS

Structural Analysis
authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002

Interaction

PhysicalInteraction Rv2973c

shahanup86

ISS

Structural Analysis
authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999

Interaction

PhysicalInteraction Rv2973c

shahanup86

ISS

Spectrophotometric
D. Schnappinger,S. Ehrt,MI. Voskuil,Y. Liu,JA. Mangan,IM. Monahan,G. Dolganov,B. Efron,PD. Butcher,C. Nathan,GK. Schoolnik Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment. J. Exp. Med. 2003

Interaction

PhysicalInteraction Rv2973c

shahanup86

ISS

Spectrophotometric
authors,P. McGlynn,AA. Mahdi,RG. Lloyd Characterisation of the catalytically active form of RecG helicase. Nucleic Acids Res. 2000

Interaction

PhysicalInteraction Rv2973c

shahanup86

ISS

Spectrophotometric
authors,AV. Gregg,P. McGlynn,RP. Jaktaji,RG. Lloyd Direct rescue of stalled DNA replication forks via the combined action of PriA and RecG helicase activities. Mol. Cell 2002

Interaction

PhysicalInteraction Rv2973c

shahanup86

ISS

Spectrophotometric
authors,ME. Robu,RB. Inman,MM. Cox Situational repair of replication forks: roles of RecG and RecA proteins. J. Biol. Chem. 2004

Interaction

PhysicalInteraction Rv2973c

shahanup86

ISS

Spectrophotometric
authors,MR. Singleton,S. Scaife,DB. Wigley Structural analysis of DNA replication fork reversal by RecG. Cell 2001

Interaction

PhysicalInteraction Rv2973c

shahanup86

ISS

Spectrophotometric
authors,GJ. Sharples,SM. Ingleston,RG. Lloyd Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA. J. Bacteriol. 1999

Interaction

PhysicalInteraction Rv2603c

sureshks89

ISA

authors,MY. Galperin,EV. Koonin From complete genome sequence to 'complete' understanding? Trends Biotechnol. 2010

Interaction

PhysicalInteraction Rv2603c

sureshks89

ISA

authors,H. Liang,L. Li,Z. Dong,MG. Surette,K. Duan The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production. J. Bacteriol. 2008

Citation

Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. PC. Brooks, F. Movahedzadeh et al. J. Bacteriol. 2001

shahanup86

IEP

11443079

Co-expression (Functional linkage)

Interaction

PhysicalInteraction Rv2592c

shahanup86

IEP

Co-expression (Functional linkage)
PC. Brooks, F. Movahedzadeh et al. Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. J. Bacteriol. 2001

Interaction

PhysicalInteraction Rv2593c

shahanup86

IEP

Citation

Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. JR. Prabu, S. Thamotharan et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006

shahanup86

IEP

16880543

Co-expression (Functional linkage)

Interaction

PhysicalInteraction Rv2592c

shahanup86

IEP

Co-expression (Functional linkage)
JR. Prabu, S. Thamotharan et al. Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006

Interaction

PhysicalInteraction Rv2593c

shahanup86

IEP

Citation

Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. PC. Brooks, F. Movahedzadeh et al. J. Bacteriol. 2001

shahanup86

IEP

11443079

Co-expression (Functional linkage)

Interaction

PhysicalInteraction Rv2592c

shahanup86

IEP

Interaction

PhysicalInteraction Rv2593c

shahanup86

IEP

Citation

Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. JR. Prabu, S. Thamotharan et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006

shahanup86

IEP

16880543

Co-expression (Functional linkage)

Interaction

PhysicalInteraction Rv2592c

shahanup86

IEP

Interaction

PhysicalInteraction Rv2593c

shahanup86

IEP

Interaction

PhysicalInteraction Rv2593c

shahanup86

IDA

Structural Analysis
JR. Prabu, S. Thamotharan et al. Crystallographic and modelling studies on Mycobacterium tuberculosis RuvA Additional role of RuvB-binding domain and inter species variability. Biochim. Biophys. Acta 2009

Interaction

PhysicalInteraction Rv2593c

shahanup86

IDA

Structural Analysis
JS. Khanduja, P. Tripathi et al. Mycobacterium tuberculosis RuvA Induces Two Distinct Types of Structural Distortions between the Homologous and Heterologous Holliday Junctions (dagger). Biochemistry 2008

Interaction

PhysicalInteraction Rv2593c

shahanup86

IDA

Structural Analysis
authors,CV. Privezentzev,A. Keeley,B. Sigala,IR. Tsaneva The role of RuvA octamerization for RuvAB function in vitro and in vivo. J. Biol. Chem. 2005

Interaction

PhysicalInteraction Rv2593c

shahanup86

IDA

Structural Analysis
JR. Prabu, S. Thamotharan et al. Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2006

Interaction

PhysicalInteraction Rv2593c

shahanup86

IDA

Structural Analysis
PC. Brooks, F. Movahedzadeh et al. Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding. J. Bacteriol. 2001

Interaction

Regulatory Rv0616c

akankshajain.21

IEP

Co-expression (Functional linkage)
T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003

Interaction

RegulatedBy Rv2720

yamir.moreno

TAS

Literature previously reported link (from Balazsi et al. 2008). Traceable author statement to experimental support.
G. Balzsi, AP. Heath et al. The temporal response of the Mycobacterium tuberculosis gene regulatory network during growth arrest. Mol. Syst. Biol. 2008

Interaction

RegulatedBy Rv0491

yamir.moreno

IEP

Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003

Other

TBPWY:Recombination repair

vmizrahi

recA-independent DNA damage-induced

Other

TBPWY:Recombination repair

vmizrahi

Increased expression in Mtb from clinical lung samples

Comments