TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2594c/ruvC:

update plot	correlation	link to info on gene
Rv3139/fadE24	(cc=0.6078)	info on Rv3139/fadE24
Rv3577/-	(cc=0.5449)	info on Rv3577/-
Rv2516c/-	(cc=0.518)	info on Rv2516c/-
Rv0436c/pssA	(cc=0.5065)	info on Rv0436c/pssA
Rv0437c/psd	(cc=0.4974)	info on Rv0437c/psd
Rv0551c/fadD8	(cc=0.4896)	info on Rv0551c/fadD8
Rv0143c/-	(cc=0.4891)	info on Rv0143c/-
Rv3742c/-	(cc=0.4885)	info on Rv3742c/-
Rv1068c/PE_PGRS20	(cc=0.4855)	info on Rv1068c/PE_PGRS20
Rv1347c/mbtK	(cc=0.481)	info on Rv1347c/mbtK

Correlation of Rv2594c/ruvC with Rv3139/fadE24

Normalized LFCs for Rv2594c/ruvC:
(description and provenance of datasets)

	Rv2594c/ruvC	Rv3139/fadE24
Fe_supp_jason_reseq	0.218	0.292
low_pH_jason_reseq	0.0	-0.738
NO_jason_reseq	0.0	-1.21
B6_jason_reseq	0.0	-0.934
MHCII_jason_reseq	0.0	-1.22
Isoniazid02	-0.351	-0.604
Rifampicin4	-1.026	-3.893
Ethambutol3	-0.461	-2.126
Meropenem3	-0.289	-3.097
Vancomycin16	-1.005	-3.815
Rv2680_day32	0.0	-2.504
H37Rv_KO_MarP	0.0	-1.547
hypoxia_3wks	0.0	-0.77
hypoxia_6wks	0.0	-0.054
glycerol	0.0	-0.287
cholesterol	0.0	-1.387
AJ	0.0	-1.39
Bibs02	0.0	-0.758
Bibs02c	0.0	-1.052
BL6	0.0	-0.629
BL6a	0.0	-0.558
BXD01	0.0	-1.52
BXD010	0.0	-0.426
BXD011	0.0	-0.268
BXD03	0.0	-0.522
BXD04	0.0	-0.827
BXD05	0.0	-0.9
BXD06	0.0	-0.671
BXD07	0.0	-0.535
BXD08	0.0	-0.842
BXD09	0.0	-0.505
CAST	0.0	-1.23
CCcont	0.733	0.979
DS01	0.0	-0.139
DS02	0.0	-0.309
DS04	0.0	-0.697
DS0c	0.0	-0.357
GP01	0.0	-1.759
GP02	0.0	-1.4
GP0c	0.0	-2.068
NOD	0.0	0.566
NZO	0.0	-0.663
PWK	0.0	-0.196
H37Rv_KO_CtpC	0.0	-0.031
H37Rv_KO_CtpD	0.0	0.462
H37Rv_KO_Rv1272	0.0	-0.397
H37Rv_KO_SugABC	0.0	-1.493
H37Rv_KO_MbtN	0.0	-0.807
Trans05	0.0	-0.158
macrophage_unactivated	0.0	-0.344
IL1	0.0	0.228
Rapamycin	0.0	-0.249
Tcell	0.0	-0.544
GMCSF	0.0	-1.31
IFNab	0.0	1.351
IFNg	0.0	-0.949
IFNg_GMCSF1	0.0	-1.92
Rv1432_day32	0.0	-2.607
Rv1565c_day32	0.0	-0.965
secA2_input	0.412	-0.086
delta_Rv3594	0.211	-2.521
delta_Rv3717	0.0	-2.81
delta_Rv3811	0.0	-2.06
delta_Rv0954	0.99	1.925
PonA1	0.304	0.822
EccD1_KO	0.0	0.303
EspI_KO	-0.394	0.04
PE35_KO	0.703	0.079
PPE68_KO	0.0	0.0
glycerol2	0.0	-0.643
lignocerate	0.0	-0.924
oleate	0.0	-1.418
phosphatidylcholine	0.0	-0.774
acetate	0.63	-0.111
glucAc	0.0	-0.069
Rv0950ko	0.38	1.291
Rv1096ko	0.38	1.782
Rv3684ko	0.789	1.615
delta_otsA_trehalose	1.482	0.044