TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3392c/cmaA1:

update plot	correlation	link to info on gene
Rv1638A/-	(cc=0.5142)	info on Rv1638A/-
Rv1742/-	(cc=0.4832)	info on Rv1742/-
Rv0866/moaE2	(cc=0.4786)	info on Rv0866/moaE2
Rv2806/-	(cc=0.4722)	info on Rv2806/-
Rv0837c/-	(cc=0.4646)	info on Rv0837c/-
Rv1075c/-	(cc=0.4553)	info on Rv1075c/-
Rv1982A/vapB36	(cc=0.4465)	info on Rv1982A/vapB36
Rv1149/-	(cc=0.4458)	info on Rv1149/-
Rv1773c/-	(cc=0.4398)	info on Rv1773c/-
Rv2966c/-	(cc=0.4394)	info on Rv2966c/-

Correlation of Rv3392c/cmaA1 with Rv1149/-

Normalized LFCs for Rv3392c/cmaA1:
(description and provenance of datasets)

	Rv3392c/cmaA1	Rv1149/-
Fe_supp_jason_reseq	0.373	-1.566
low_pH_jason_reseq	0.783	-1.532
NO_jason_reseq	-1.748	-0.37
B6_jason_reseq	0.085	0.532
MHCII_jason_reseq	1.089	0.553
Isoniazid02	0.054	0.048
Rifampicin4	-0.772	1.235
Ethambutol3	-0.14	0.495
Meropenem3	0.086	0.767
Vancomycin16	0.329	0.499
Rv2680_day32	-0.365	-0.613
H37Rv_KO_MarP	0.689	0.073
hypoxia_3wks	0.319	1.236
hypoxia_6wks	1.244	1.347
glycerol	0.844	0.255
cholesterol	0.07	0.146
AJ	0.726	0.813
Bibs02	-1.179	0.287
Bibs02c	0.55	1.363
BL6	-0.731	-0.264
BL6a	0.936	0.913
BXD01	0.309	0.281
BXD010	-0.206	0.804
BXD011	0.742	-0.142
BXD03	0.227	0.807
BXD04	0.208	-0.546
BXD05	1.133	0.505
BXD06	0.482	0.326
BXD07	0.725	0.399
BXD08	0.656	-0.707
BXD09	0.387	0.493
CAST	-0.462	0.232
CCcont	-0.633	-0.865
DS01	1.237	0.743
DS02	1.267	0.432
DS04	-0.167	0.195
DS0c	0.484	0.03
GP01	-1.899	-2.51
GP02	-0.955	-1.23
GP0c	-1.78	-0.676
NOD	0.532	1.751
NZO	-0.481	0.0
PWK	1.124	0.895
H37Rv_KO_CtpC	0.625	3.594
H37Rv_KO_CtpD	0.853	1.213
H37Rv_KO_Rv1272	-0.745	0.01
H37Rv_KO_SugABC	0.984	-1.653
H37Rv_KO_MbtN	1.266	0.607
Trans05	0.456	0.951
macrophage_unactivated	-0.051	-0.432
IL1	0.181	0.059
Rapamycin	0.0	0.092
Tcell	-0.264	0.254
GMCSF	0.784	0.106
IFNab	0.78	-0.184
IFNg	-0.444	-0.136
IFNg_GMCSF1	-0.578	-0.063
Rv1432_day32	0.394	0.658
Rv1565c_day32	-0.283	1.054
secA2_input	0.85	0.734
delta_Rv3594	2.022	0.165
delta_Rv3717	2.085	1.187
delta_Rv3811	2.411	0.745
delta_Rv0954	2.335	0.933
PonA1	1.021	-0.591
EccD1_KO	0.47	1.885
EspI_KO	1.075	1.6
PE35_KO	0.61	1.671
PPE68_KO	1.206	2.451
glycerol2	-0.474	-0.719
lignocerate	-0.363	-0.865
oleate	0.0	-0.293
phosphatidylcholine	-0.21	-0.629
acetate	-0.027	-0.547
glucAc	-1.118	-0.572
Rv0950ko	0.763	0.859
Rv1096ko	0.712	1.517
Rv3684ko	1.094	0.933
delta_otsA_trehalose	-0.239	-0.873