TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3191c/-:

update plot	correlation	link to info on gene
Rv0399c/lpqK	(cc=0.6372)	info on Rv0399c/lpqK
Rv0940c/-	(cc=0.6145)	info on Rv0940c/-
Rv0160c/PE4	(cc=0.5738)	info on Rv0160c/PE4
Rv0456B/mazE1	(cc=0.5655)	info on Rv0456B/mazE1
Rv0932c/pstS2	(cc=0.5643)	info on Rv0932c/pstS2
Rv0342/iniA	(cc=0.5544)	info on Rv0342/iniA
Rv3233c/-	(cc=0.5308)	info on Rv3233c/-
Rv0115/hddA	(cc=0.5259)	info on Rv0115/hddA
Rv0413/mutT3	(cc=0.5236)	info on Rv0413/mutT3
Rv3365c/-	(cc=0.5124)	info on Rv3365c/-

Correlation of Rv3191c/- with Rv3365c/-

Normalized LFCs for Rv3191c/-:
(description and provenance of datasets)

	Rv3191c/-	Rv3365c/-
Fe_supp_jason_reseq	-0.024	-0.106
low_pH_jason_reseq	-0.37	-1.225
NO_jason_reseq	-0.06	-0.656
B6_jason_reseq	0.47	0.089
MHCII_jason_reseq	0.448	-0.529
Isoniazid02	-1.929	-1.793
Rifampicin4	0.625	-0.341
Ethambutol3	-2.151	-1.694
Meropenem3	-0.361	-0.516
Vancomycin16	-0.907	-0.114
Rv2680_day32	0.071	0.184
H37Rv_KO_MarP	0.409	-1.158
hypoxia_3wks	-0.395	-0.61
hypoxia_6wks	-0.683	-0.038
glycerol	-0.176	-0.647
cholesterol	-0.111	-0.054
AJ	0.424	0.0
Bibs02	0.283	-0.24
Bibs02c	0.57	0.203
BL6	-0.065	0.24
BL6a	0.716	0.27
BXD01	-0.167	0.326
BXD010	0.178	0.149
BXD011	0.436	-0.009
BXD03	0.247	0.4
BXD04	0.221	0.184
BXD05	0.692	0.183
BXD06	0.452	0.256
BXD07	0.158	0.171
BXD08	0.253	0.181
BXD09	0.623	0.209
CAST	0.439	-0.174
CCcont	0.151	0.155
DS01	0.862	0.068
DS02	0.285	0.769
DS04	1.062	0.859
DS0c	0.292	0.481
GP01	0.304	0.523
GP02	-0.484	1.221
GP0c	-0.684	0.135
NOD	0.539	0.277
NZO	0.585	-0.214
PWK	0.624	0.352
H37Rv_KO_CtpC	0.291	0.058
H37Rv_KO_CtpD	0.08	0.875
H37Rv_KO_Rv1272	0.547	0.362
H37Rv_KO_SugABC	0.526	0.654
H37Rv_KO_MbtN	0.429	0.401
Trans05	0.094	0.908
macrophage_unactivated	-0.174	0.615
IL1	-0.047	0.418
Rapamycin	-0.169	0.285
Tcell	-0.606	0.055
GMCSF	0.013	0.222
IFNab	0.287	1.267
IFNg	0.102	0.738
IFNg_GMCSF1	0.33	0.49
Rv1432_day32	0.316	0.471
Rv1565c_day32	-0.591	-0.649
secA2_input	-0.632	-0.21
delta_Rv3594	-0.08	0.014
delta_Rv3717	-0.216	0.177
delta_Rv3811	0.025	-0.217
delta_Rv0954	-0.26	-0.226
PonA1	0.123	0.335
EccD1_KO	-0.217	-0.059
EspI_KO	0.371	-0.402
PE35_KO	0.082	-0.773
PPE68_KO	-0.189	-0.419
glycerol2	-0.113	0.573
lignocerate	0.516	0.302
oleate	-0.413	-0.132
phosphatidylcholine	0.084	-0.623
acetate	0.57	1.385
glucAc	0.485	0.873
Rv0950ko	0.109	-0.072
Rv1096ko	0.38	1.179
Rv3684ko	0.301	1.009
delta_otsA_trehalose	-0.138	0.304