TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3191c/-:

update plot	correlation	link to info on gene
Rv0399c/lpqK	(cc=0.6372)	info on Rv0399c/lpqK
Rv0940c/-	(cc=0.6145)	info on Rv0940c/-
Rv0160c/PE4	(cc=0.5738)	info on Rv0160c/PE4
Rv0456B/mazE1	(cc=0.5655)	info on Rv0456B/mazE1
Rv0932c/pstS2	(cc=0.5643)	info on Rv0932c/pstS2
Rv0342/iniA	(cc=0.5544)	info on Rv0342/iniA
Rv3233c/-	(cc=0.5308)	info on Rv3233c/-
Rv0115/hddA	(cc=0.5259)	info on Rv0115/hddA
Rv0413/mutT3	(cc=0.5236)	info on Rv0413/mutT3
Rv3365c/-	(cc=0.5124)	info on Rv3365c/-

Correlation of Rv3191c/- with Rv3233c/-

Normalized LFCs for Rv3191c/-:
(description and provenance of datasets)

	Rv3191c/-	Rv3233c/-
Fe_supp_jason_reseq	-0.024	-0.284
low_pH_jason_reseq	-0.37	-0.992
NO_jason_reseq	-0.06	0.179
B6_jason_reseq	0.47	0.054
MHCII_jason_reseq	0.448	0.65
Isoniazid02	-1.929	-1.117
Rifampicin4	0.625	0.236
Ethambutol3	-2.151	-1.294
Meropenem3	-0.361	-1.702
Vancomycin16	-0.907	-0.947
Rv2680_day32	0.071	0.518
H37Rv_KO_MarP	0.409	0.382
hypoxia_3wks	-0.395	-0.247
hypoxia_6wks	-0.683	-0.578
glycerol	-0.176	-0.995
cholesterol	-0.111	0.292
AJ	0.424	-0.034
Bibs02	0.283	-0.048
Bibs02c	0.57	0.382
BL6	-0.065	0.252
BL6a	0.716	-0.172
BXD01	-0.167	-0.537
BXD010	0.178	-0.443
BXD011	0.436	-0.305
BXD03	0.247	-0.016
BXD04	0.221	-0.282
BXD05	0.692	0.252
BXD06	0.452	-0.5
BXD07	0.158	-0.267
BXD08	0.253	-0.323
BXD09	0.623	-0.131
CAST	0.439	0.744
CCcont	0.151	-0.622
DS01	0.862	0.681
DS02	0.285	0.354
DS04	1.062	0.06
DS0c	0.292	0.327
GP01	0.304	0.382
GP02	-0.484	-0.673
GP0c	-0.684	-0.455
NOD	0.539	1.451
NZO	0.585	0.887
PWK	0.624	-0.064
H37Rv_KO_CtpC	0.291	-0.005
H37Rv_KO_CtpD	0.08	0.477
H37Rv_KO_Rv1272	0.547	-0.004
H37Rv_KO_SugABC	0.526	0.588
H37Rv_KO_MbtN	0.429	0.003
Trans05	0.094	-0.164
macrophage_unactivated	-0.174	-0.069
IL1	-0.047	-0.632
Rapamycin	-0.169	-0.371
Tcell	-0.606	-0.414
GMCSF	0.013	-0.029
IFNab	0.287	0.115
IFNg	0.102	-0.307
IFNg_GMCSF1	0.33	0.962
Rv1432_day32	0.316	0.098
Rv1565c_day32	-0.591	0.415
secA2_input	-0.632	-0.704
delta_Rv3594	-0.08	-0.072
delta_Rv3717	-0.216	-0.185
delta_Rv3811	0.025	0.39
delta_Rv0954	-0.26	-0.146
PonA1	0.123	0.898
EccD1_KO	-0.217	0.0
EspI_KO	0.371	0.031
PE35_KO	0.082	-0.146
PPE68_KO	-0.189	-0.106
glycerol2	-0.113	-0.377
lignocerate	0.516	-0.476
oleate	-0.413	0.043
phosphatidylcholine	0.084	-0.52
acetate	0.57	-0.986
glucAc	0.485	-0.808
Rv0950ko	0.109	0.482
Rv1096ko	0.38	0.591
Rv3684ko	0.301	0.553
delta_otsA_trehalose	-0.138	-0.19