TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2851c/-:

update plot	correlation	link to info on gene
Rv2240c/-	(cc=0.5973)	info on Rv2240c/-
Rv3575c/-	(cc=0.5889)	info on Rv3575c/-
Rv0442c/PPE10	(cc=0.5562)	info on Rv0442c/PPE10
Rv2237/-	(cc=0.5264)	info on Rv2237/-
Rv3194c/-	(cc=0.5052)	info on Rv3194c/-
Rv1237/sugB	(cc=0.5007)	info on Rv1237/sugB
Rv3213c/-	(cc=0.4912)	info on Rv3213c/-
Rv0432/sodC	(cc=0.4862)	info on Rv0432/sodC
Rv1987/-	(cc=0.482)	info on Rv1987/-
Rv3534c/hsaF	(cc=0.4775)	info on Rv3534c/hsaF

Correlation of Rv2851c/- with Rv0432/sodC

Normalized LFCs for Rv2851c/-:
(description and provenance of datasets)

	Rv2851c/-	Rv0432/sodC
Fe_supp_jason_reseq	-0.021	0.606
low_pH_jason_reseq	-0.852	0.609
NO_jason_reseq	2.539	0.289
B6_jason_reseq	0.843	-1.779
MHCII_jason_reseq	1.51	-1.466
Isoniazid02	0.781	-0.554
Rifampicin4	-0.319	-1.752
Ethambutol3	0.14	-0.255
Meropenem3	0.478	-0.546
Vancomycin16	-0.653	-1.21
Rv2680_day32	1.779	0.147
H37Rv_KO_MarP	0.562	0.262
hypoxia_3wks	0.809	-1.332
hypoxia_6wks	0.472	-1.234
glycerol	0.884	-0.696
cholesterol	-1.323	-0.31
AJ	-0.484	-1.519
Bibs02	0.0	-0.705
Bibs02c	-0.217	-0.762
BL6	0.463	0.12
BL6a	0.08	-0.257
BXD01	0.373	-0.753
BXD010	0.052	0.518
BXD011	0.149	-0.25
BXD03	-0.99	-0.886
BXD04	0.744	-1.171
BXD05	0.514	-1.014
BXD06	-0.091	-0.382
BXD07	-0.131	-0.061
BXD08	0.589	-0.54
BXD09	1.403	-0.062
CAST	-1.333	-1.91
CCcont	0.612	0.402
DS01	-0.517	-1.745
DS02	1.549	-0.602
DS04	-0.632	-1.872
DS0c	0.635	-1.226
GP01	2.288	-0.292
GP02	0.201	-0.491
GP0c	1.225	0.254
NOD	-0.835	-1.298
NZO	0.533	-0.21
PWK	-0.776	-1.823
H37Rv_KO_CtpC	0.248	-0.42
H37Rv_KO_CtpD	0.484	0.185
H37Rv_KO_Rv1272	0.609	-0.697
H37Rv_KO_SugABC	2.202	0.609
H37Rv_KO_MbtN	1.314	-0.345
Trans05	1.236	-1.436
macrophage_unactivated	0.956	-0.833
IL1	1.777	0.587
Rapamycin	2.55	0.11
Tcell	1.033	0.117
GMCSF	1.067	-0.177
IFNab	0.051	0.193
IFNg	3.814	0.826
IFNg_GMCSF1	4.286	0.113
Rv1432_day32	1.601	-1.246
Rv1565c_day32	-0.31	-2.504
secA2_input	-0.56	-0.985
delta_Rv3594	0.716	0.333
delta_Rv3717	0.405	-0.092
delta_Rv3811	0.882	0.739
delta_Rv0954	0.031	0.078
PonA1	-1.27	0.615
EccD1_KO	0.789	-0.829
EspI_KO	0.819	-0.95
PE35_KO	0.289	-1.604
PPE68_KO	0.451	-1.315
glycerol2	3.544	0.464
lignocerate	3.187	0.991
oleate	-1.418	-0.44
phosphatidylcholine	3.27	1.158
acetate	2.809	1.049
glucAc	2.649	0.668
Rv0950ko	0.585	0.479
Rv1096ko	0.558	0.721
Rv3684ko	1.041	0.37
delta_otsA_trehalose	2.311	0.849