TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2738c/-:

update plot	correlation	link to info on gene
Rv0399c/lpqK	(cc=0.6205)	info on Rv0399c/lpqK
Rv3919c/gid	(cc=0.5884)	info on Rv3919c/gid
Rv2650c/-	(cc=0.5845)	info on Rv2650c/-
Rv1678/-	(cc=0.5484)	info on Rv1678/-
Rv0160c/PE4	(cc=0.5353)	info on Rv0160c/PE4
Rv3572/-	(cc=0.5225)	info on Rv3572/-
Rv0940c/-	(cc=0.5083)	info on Rv0940c/-
Rv3191c/-	(cc=0.4943)	info on Rv3191c/-
Rv0968/-	(cc=0.4931)	info on Rv0968/-
Rv3291c/lrpA	(cc=0.4894)	info on Rv3291c/lrpA

Correlation of Rv2738c/- with Rv0160c/PE4

Normalized LFCs for Rv2738c/-:
(description and provenance of datasets)

	Rv2738c/-	Rv0160c/PE4
Fe_supp_jason_reseq	-0.415	0.011
low_pH_jason_reseq	1.104	-0.07
NO_jason_reseq	-1.013	-0.11
B6_jason_reseq	-1.973	0.416
MHCII_jason_reseq	-1.598	0.302
Isoniazid02	-4.829	-1.8
Rifampicin4	0.904	0.208
Ethambutol3	-3.412	-0.931
Meropenem3	-3.54	-1.482
Vancomycin16	-1.417	-0.836
Rv2680_day32	-1.982	-0.088
H37Rv_KO_MarP	0.579	0.748
hypoxia_3wks	-1.388	-0.191
hypoxia_6wks	-0.704	-0.175
glycerol	1.011	0.471
cholesterol	0.041	0.477
AJ	-0.632	0.062
Bibs02	0.366	0.886
Bibs02c	0.826	0.584
BL6	-1.448	0.188
BL6a	0.647	0.375
BXD01	-0.064	-0.029
BXD010	0.445	-0.023
BXD011	-0.063	0.241
BXD03	0.92	0.15
BXD04	0.058	0.354
BXD05	0.955	0.048
BXD06	0.235	0.316
BXD07	0.432	0.182
BXD08	0.851	0.338
BXD09	0.013	0.032
CAST	-1.875	0.427
CCcont	-1.564	-0.148
DS01	-0.89	0.281
DS02	0.274	0.584
DS04	1.116	0.126
DS0c	-1.353	-0.141
GP01	-0.109	0.358
GP02	-0.894	1.382
GP0c	0.107	-0.229
NOD	0.571	0.364
NZO	-0.139	0.887
PWK	-0.997	0.193
H37Rv_KO_CtpC	1.283	0.447
H37Rv_KO_CtpD	0.387	1.091
H37Rv_KO_Rv1272	0.226	1.015
H37Rv_KO_SugABC	-1.147	0.612
H37Rv_KO_MbtN	0.393	0.485
Trans05	1.008	0.807
macrophage_unactivated	-0.657	-0.354
IL1	-0.267	0.098
Rapamycin	0.298	0.239
Tcell	0.456	-0.248
GMCSF	-1.048	-0.09
IFNab	-0.103	0.039
IFNg	0.406	0.294
IFNg_GMCSF1	-0.129	0.085
Rv1432_day32	0.096	0.339
Rv1565c_day32	-0.76	0.458
secA2_input	0.387	-0.333
delta_Rv3594	0.277	-0.099
delta_Rv3717	0.147	-0.239
delta_Rv3811	0.891	-0.223
delta_Rv0954	0.0	0.358
PonA1	0.19	0.126
EccD1_KO	0.576	-0.444
EspI_KO	0.063	0.074
PE35_KO	-1.138	-0.446
PPE68_KO	-0.243	-0.221
glycerol2	-0.958	0.276
lignocerate	-0.401	0.284
oleate	-1.46	0.216
phosphatidylcholine	-0.287	0.387
acetate	0.048	0.083
glucAc	-0.127	0.264
Rv0950ko	0.917	0.479
Rv1096ko	-0.051	-0.13
Rv3684ko	0.688	0.134
delta_otsA_trehalose	0.382	0.026