TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2724c/fadE20:

update plot	correlation	link to info on gene
Rv2489c/-	(cc=0.6298)	info on Rv2489c/-
Rv1101c/-	(cc=0.6137)	info on Rv1101c/-
Rv0796/-	(cc=0.5419)	info on Rv0796/-
Rv3233c/-	(cc=0.5394)	info on Rv3233c/-
Rv2479c/-	(cc=0.5235)	info on Rv2479c/-
Rv1567c/-	(cc=0.5234)	info on Rv1567c/-
Rv3326/-	(cc=0.5187)	info on Rv3326/-
Rv2167c/-	(cc=0.5137)	info on Rv2167c/-
Rv2355/-	(cc=0.5025)	info on Rv2355/-
Rv0932c/pstS2	(cc=0.5012)	info on Rv0932c/pstS2

Correlation of Rv2724c/fadE20 with Rv1567c/-

Normalized LFCs for Rv2724c/fadE20:
(description and provenance of datasets)

	Rv2724c/fadE20	Rv1567c/-
Fe_supp_jason_reseq	-0.052	0.767
low_pH_jason_reseq	-0.571	-0.627
NO_jason_reseq	0.215	0.57
B6_jason_reseq	0.553	1.235
MHCII_jason_reseq	-0.271	1.475
Isoniazid02	-0.431	0.17
Rifampicin4	0.317	0.008
Ethambutol3	-1.149	0.027
Meropenem3	-1.343	-0.162
Vancomycin16	-0.69	-1.098
Rv2680_day32	0.171	0.08
H37Rv_KO_MarP	0.282	-1.002
hypoxia_3wks	0.315	0.0
hypoxia_6wks	0.808	0.516
glycerol	-0.24	-0.922
cholesterol	-0.028	0.833
AJ	0.308	0.397
Bibs02	0.25	1.429
Bibs02c	0.467	1.132
BL6	0.089	0.8
BL6a	0.288	1.179
BXD01	0.361	0.751
BXD010	0.311	0.698
BXD011	0.141	0.41
BXD03	0.115	0.526
BXD04	0.583	0.66
BXD05	0.583	1.028
BXD06	0.171	0.772
BXD07	0.214	0.823
BXD08	0.082	0.557
BXD09	-0.129	0.901
CAST	0.639	0.484
CCcont	-0.202	0.438
DS01	0.462	0.932
DS02	0.451	0.993
DS04	0.448	0.004
DS0c	0.432	0.919
GP01	0.342	0.938
GP02	0.353	1.096
GP0c	-0.258	0.623
NOD	0.801	1.23
NZO	0.397	0.184
PWK	0.76	0.698
H37Rv_KO_CtpC	0.145	0.358
H37Rv_KO_CtpD	0.258	1.02
H37Rv_KO_Rv1272	-0.206	0.468
H37Rv_KO_SugABC	0.621	0.84
H37Rv_KO_MbtN	-0.248	0.264
Trans05	0.185	0.562
macrophage_unactivated	-0.398	0.395
IL1	-0.288	-0.199
Rapamycin	-0.712	-0.123
Tcell	-0.482	-0.248
GMCSF	-0.94	-0.338
IFNab	-0.209	0.354
IFNg	-0.58	0.091
IFNg_GMCSF1	-0.352	0.955
Rv1432_day32	-0.039	-0.413
Rv1565c_day32	0.319	0.531
secA2_input	-0.579	-0.661
delta_Rv3594	0.944	0.439
delta_Rv3717	0.439	0.857
delta_Rv3811	0.473	0.225
delta_Rv0954	0.731	1.813
PonA1	0.568	0.395
EccD1_KO	-0.306	-0.559
EspI_KO	0.305	-0.987
PE35_KO	-0.207	-0.263
PPE68_KO	-0.566	-0.717
glycerol2	-0.163	-0.09
lignocerate	-0.402	0.356
oleate	0.381	-0.679
phosphatidylcholine	-0.3	-0.211
acetate	-0.816	-0.121
glucAc	-0.573	-0.334
Rv0950ko	-0.054	0.528
Rv1096ko	-0.739	-0.477
Rv3684ko	0.059	0.075
delta_otsA_trehalose	-0.182	-0.301