TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2724c/fadE20:

update plot	correlation	link to info on gene
Rv2489c/-	(cc=0.6298)	info on Rv2489c/-
Rv1101c/-	(cc=0.6137)	info on Rv1101c/-
Rv0796/-	(cc=0.5419)	info on Rv0796/-
Rv3233c/-	(cc=0.5394)	info on Rv3233c/-
Rv2479c/-	(cc=0.5235)	info on Rv2479c/-
Rv1567c/-	(cc=0.5234)	info on Rv1567c/-
Rv3326/-	(cc=0.5187)	info on Rv3326/-
Rv2167c/-	(cc=0.5137)	info on Rv2167c/-
Rv2355/-	(cc=0.5025)	info on Rv2355/-
Rv0932c/pstS2	(cc=0.5012)	info on Rv0932c/pstS2

Correlation of Rv2724c/fadE20 with Rv1101c/-

Normalized LFCs for Rv2724c/fadE20:
(description and provenance of datasets)

	Rv2724c/fadE20	Rv1101c/-
Fe_supp_jason_reseq	-0.052	-0.557
low_pH_jason_reseq	-0.571	-0.992
NO_jason_reseq	0.215	-0.633
B6_jason_reseq	0.553	0.396
MHCII_jason_reseq	-0.271	0.097
Isoniazid02	-0.431	-0.997
Rifampicin4	0.317	-0.428
Ethambutol3	-1.149	-1.253
Meropenem3	-1.343	-0.998
Vancomycin16	-0.69	-2.417
Rv2680_day32	0.171	0.58
H37Rv_KO_MarP	0.282	0.516
hypoxia_3wks	0.315	1.16
hypoxia_6wks	0.808	1.086
glycerol	-0.24	-0.111
cholesterol	-0.028	0.03
AJ	0.308	-0.163
Bibs02	0.25	0.168
Bibs02c	0.467	0.74
BL6	0.089	-0.027
BL6a	0.288	0.32
BXD01	0.361	-0.137
BXD010	0.311	0.054
BXD011	0.141	-0.037
BXD03	0.115	-0.36
BXD04	0.583	-0.13
BXD05	0.583	0.48
BXD06	0.171	0.158
BXD07	0.214	-0.161
BXD08	0.082	0.088
BXD09	-0.129	0.059
CAST	0.639	0.387
CCcont	-0.202	-0.14
DS01	0.462	0.888
DS02	0.451	0.578
DS04	0.448	0.0
DS0c	0.432	0.222
GP01	0.342	-0.245
GP02	0.353	0.773
GP0c	-0.258	0.063
NOD	0.801	-0.21
NZO	0.397	0.569
PWK	0.76	-0.092
H37Rv_KO_CtpC	0.145	-0.51
H37Rv_KO_CtpD	0.258	0.375
H37Rv_KO_Rv1272	-0.206	0.555
H37Rv_KO_SugABC	0.621	1.071
H37Rv_KO_MbtN	-0.248	0.735
Trans05	0.185	0.867
macrophage_unactivated	-0.398	-0.051
IL1	-0.288	-0.128
Rapamycin	-0.712	-0.098
Tcell	-0.482	-0.355
GMCSF	-0.94	-0.333
IFNab	-0.209	0.647
IFNg	-0.58	-0.029
IFNg_GMCSF1	-0.352	0.0
Rv1432_day32	-0.039	0.958
Rv1565c_day32	0.319	0.861
secA2_input	-0.579	-0.667
delta_Rv3594	0.944	0.881
delta_Rv3717	0.439	0.813
delta_Rv3811	0.473	0.909
delta_Rv0954	0.731	0.789
PonA1	0.568	0.29
EccD1_KO	-0.306	-0.049
EspI_KO	0.305	0.411
PE35_KO	-0.207	0.44
PPE68_KO	-0.566	0.259
glycerol2	-0.163	-0.935
lignocerate	-0.402	-0.76
oleate	0.381	-0.153
phosphatidylcholine	-0.3	-0.66
acetate	-0.816	-1.175
glucAc	-0.573	-0.837
Rv0950ko	-0.054	0.033
Rv1096ko	-0.739	-0.347
Rv3684ko	0.059	0.74
delta_otsA_trehalose	-0.182	0.238