TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2592c/ruvB:

update plot	correlation	link to info on gene
Rv2202c/adoK	(cc=0.6533)	info on Rv2202c/adoK
Rv0651/rplJ	(cc=0.5505)	info on Rv0651/rplJ
Rv2965c/kdtB	(cc=0.5422)	info on Rv2965c/kdtB
Rv1636/TB15.3	(cc=0.5406)	info on Rv1636/TB15.3
Rv2246/kasB	(cc=0.5276)	info on Rv2246/kasB
Rv1177/fdxC	(cc=0.5242)	info on Rv1177/fdxC
Rv2827c/-	(cc=0.5108)	info on Rv2827c/-
Rv2256c/-	(cc=0.5085)	info on Rv2256c/-
Rv2603c/-	(cc=0.5)	info on Rv2603c/-
Rv1685c/-	(cc=0.4829)	info on Rv1685c/-

Correlation of Rv2592c/ruvB with Rv1685c/-

Normalized LFCs for Rv2592c/ruvB:
(description and provenance of datasets)

	Rv2592c/ruvB	Rv1685c/-
Fe_supp_jason_reseq	0.0	0.415
low_pH_jason_reseq	0.0	0.0
NO_jason_reseq	0.0	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	0.156	-0.551
Rifampicin4	-0.311	-0.653
Ethambutol3	-0.293	-0.461
Meropenem3	-0.138	-0.138
Vancomycin16	-0.639	-0.639
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	-0.313	-1.964
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	0.0	0.0
cholesterol	0.0	1.123
AJ	0.0	0.0
Bibs02	0.0	0.0
Bibs02c	0.0	0.0
BL6	0.0	0.0
BL6a	0.0	0.0
BXD01	0.0	0.0
BXD010	0.0	0.0
BXD011	0.0	0.127
BXD03	0.0	0.0
BXD04	0.0	0.0
BXD05	0.0	0.0
BXD06	0.0	0.0
BXD07	0.0	0.0
BXD08	0.0	0.0
BXD09	0.0	0.0
CAST	0.0	0.0
CCcont	0.285	1.662
DS01	0.0	0.0
DS02	0.0	0.0
DS04	0.0	0.194
DS0c	0.0	0.413
GP01	0.0	0.099
GP02	0.0	0.0
GP0c	0.0	0.0
NOD	0.0	0.0
NZO	0.0	0.0
PWK	0.0	0.0
H37Rv_KO_CtpC	0.0	0.162
H37Rv_KO_CtpD	0.0	0.0
H37Rv_KO_Rv1272	0.0	0.0
H37Rv_KO_SugABC	0.0	0.099
H37Rv_KO_MbtN	0.0	0.103
Trans05	0.0	0.0
macrophage_unactivated	0.0	0.0
IL1	0.0	0.0
Rapamycin	0.0	0.0
Tcell	0.0	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	0.0	0.0
IFNg_GMCSF1	0.0	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	1.263	0.816
delta_Rv3594	0.402	0.402
delta_Rv3717	0.0	0.0
delta_Rv3811	0.391	0.205
delta_Rv0954	0.34	2.048
PonA1	0.304	1.154
EccD1_KO	-0.454	0.243
EspI_KO	0.0	-0.456
PE35_KO	-0.403	0.983
PPE68_KO	0.0	2.95
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.0
glucAc	0.0	0.0
Rv0950ko	0.0	-0.582
Rv1096ko	-0.347	-0.793
Rv3684ko	-1.241	-1.916
delta_otsA_trehalose	-0.889	0.0