TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2585c/-:

update plot	correlation	link to info on gene
Rv1035c/-	(cc=0.5171)	info on Rv1035c/-
Rv1773c/-	(cc=0.495)	info on Rv1773c/-
Rv0825c/-	(cc=0.4934)	info on Rv0825c/-
Rv1587c/-	(cc=0.4886)	info on Rv1587c/-
Rv0402c/mmpL1	(cc=0.4785)	info on Rv0402c/mmpL1
Rv3509c/ilvX	(cc=0.456)	info on Rv3509c/ilvX
Rv3649/-	(cc=0.4399)	info on Rv3649/-
Rv0646c/lipG	(cc=0.4322)	info on Rv0646c/lipG
Rv3695/-	(cc=0.4307)	info on Rv3695/-
Rv1767/-	(cc=0.4245)	info on Rv1767/-

Correlation of Rv2585c/- with Rv1767/-

Normalized LFCs for Rv2585c/-:
(description and provenance of datasets)

	Rv2585c/-	Rv1767/-
Fe_supp_jason_reseq	0.229	0.039
low_pH_jason_reseq	-1.047	-0.979
NO_jason_reseq	-0.798	0.528
B6_jason_reseq	0.492	-0.67
MHCII_jason_reseq	0.212	-0.553
Isoniazid02	0.028	0.207
Rifampicin4	0.615	0.236
Ethambutol3	0.924	0.753
Meropenem3	0.945	0.035
Vancomycin16	0.127	-0.162
Rv2680_day32	0.151	-0.363
H37Rv_KO_MarP	-0.913	0.113
hypoxia_3wks	-0.514	-0.881
hypoxia_6wks	-0.505	-0.912
glycerol	-0.092	0.949
cholesterol	0.846	-0.57
AJ	0.519	0.499
Bibs02	0.616	1.48
Bibs02c	0.358	-0.383
BL6	0.356	0.832
BL6a	0.505	0.426
BXD01	0.008	-0.108
BXD010	0.812	0.465
BXD011	0.672	1.117
BXD03	0.487	0.071
BXD04	0.17	-0.033
BXD05	0.746	0.602
BXD06	0.481	0.167
BXD07	0.367	0.394
BXD08	0.305	-0.258
BXD09	0.441	-0.051
CAST	0.143	0.496
CCcont	-0.558	-0.53
DS01	0.217	-0.587
DS02	0.109	0.706
DS04	0.617	0.101
DS0c	-0.099	-1.216
GP01	0.3	0.268
GP02	0.091	2.154
GP0c	-0.276	1.155
NOD	0.628	0.368
NZO	0.298	0.737
PWK	1.131	-0.2
H37Rv_KO_CtpC	-1.125	-0.315
H37Rv_KO_CtpD	-0.715	-0.117
H37Rv_KO_Rv1272	-0.278	0.748
H37Rv_KO_SugABC	0.296	-0.054
H37Rv_KO_MbtN	0.583	-0.019
Trans05	0.476	0.592
macrophage_unactivated	0.316	0.385
IL1	-0.374	-0.558
Rapamycin	-0.246	-0.184
Tcell	-0.632	-0.723
GMCSF	1.17	0.026
IFNab	0.351	-0.339
IFNg	0.436	-0.535
IFNg_GMCSF1	1.144	0.06
Rv1432_day32	1.643	0.383
Rv1565c_day32	0.433	1.232
secA2_input	-0.719	-2.855
delta_Rv3594	0.805	1.638
delta_Rv3717	0.75	1.457
delta_Rv3811	0.516	2.045
delta_Rv0954	0.185	1.659
PonA1	0.369	-0.95
EccD1_KO	0.628	0.109
EspI_KO	0.408	1.56
PE35_KO	-0.327	-0.516
PPE68_KO	0.067	0.07
glycerol2	-0.342	-1.211
lignocerate	-0.704	-0.408
oleate	0.312	-0.498
phosphatidylcholine	-0.668	-0.424
acetate	-0.432	0.166
glucAc	-0.641	-0.416
Rv0950ko	0.576	0.694
Rv1096ko	1.27	0.477
Rv3684ko	1.238	1.945
delta_otsA_trehalose	-0.21	-0.994