TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2585c/-:

update plot	correlation	link to info on gene
Rv1035c/-	(cc=0.5171)	info on Rv1035c/-
Rv1773c/-	(cc=0.495)	info on Rv1773c/-
Rv0825c/-	(cc=0.4934)	info on Rv0825c/-
Rv1587c/-	(cc=0.4886)	info on Rv1587c/-
Rv0402c/mmpL1	(cc=0.4785)	info on Rv0402c/mmpL1
Rv3509c/ilvX	(cc=0.456)	info on Rv3509c/ilvX
Rv3649/-	(cc=0.4399)	info on Rv3649/-
Rv0646c/lipG	(cc=0.4322)	info on Rv0646c/lipG
Rv3695/-	(cc=0.4307)	info on Rv3695/-
Rv1767/-	(cc=0.4245)	info on Rv1767/-

Correlation of Rv2585c/- with Rv1587c/-

Normalized LFCs for Rv2585c/-:
(description and provenance of datasets)

	Rv2585c/-	Rv1587c/-
Fe_supp_jason_reseq	0.229	-0.292
low_pH_jason_reseq	-1.047	-0.253
NO_jason_reseq	-0.798	0.26
B6_jason_reseq	0.492	0.172
MHCII_jason_reseq	0.212	0.352
Isoniazid02	0.028	0.201
Rifampicin4	0.615	0.0
Ethambutol3	0.924	0.485
Meropenem3	0.945	1.945
Vancomycin16	0.127	-0.069
Rv2680_day32	0.151	-0.18
H37Rv_KO_MarP	-0.913	-0.135
hypoxia_3wks	-0.514	0.044
hypoxia_6wks	-0.505	-0.583
glycerol	-0.092	-1.005
cholesterol	0.846	-0.17
AJ	0.519	0.607
Bibs02	0.616	0.264
Bibs02c	0.358	-0.106
BL6	0.356	0.71
BL6a	0.505	0.198
BXD01	0.008	-0.162
BXD010	0.812	0.572
BXD011	0.672	0.759
BXD03	0.487	-0.009
BXD04	0.17	0.415
BXD05	0.746	0.286
BXD06	0.481	0.133
BXD07	0.367	0.138
BXD08	0.305	0.36
BXD09	0.441	-0.017
CAST	0.143	0.332
CCcont	-0.558	-0.521
DS01	0.217	0.25
DS02	0.109	0.651
DS04	0.617	0.616
DS0c	-0.099	0.786
GP01	0.3	0.51
GP02	0.091	0.794
GP0c	-0.276	0.229
NOD	0.628	-0.143
NZO	0.298	0.808
PWK	1.131	0.71
H37Rv_KO_CtpC	-1.125	-0.459
H37Rv_KO_CtpD	-0.715	0.287
H37Rv_KO_Rv1272	-0.278	-0.803
H37Rv_KO_SugABC	0.296	-1.055
H37Rv_KO_MbtN	0.583	-0.444
Trans05	0.476	-0.075
macrophage_unactivated	0.316	-0.533
IL1	-0.374	-0.347
Rapamycin	-0.246	-0.485
Tcell	-0.632	-0.906
GMCSF	1.17	-0.446
IFNab	0.351	-1.125
IFNg	0.436	0.195
IFNg_GMCSF1	1.144	-0.305
Rv1432_day32	1.643	2.374
Rv1565c_day32	0.433	0.022
secA2_input	-0.719	-0.596
delta_Rv3594	0.805	0.658
delta_Rv3717	0.75	-0.115
delta_Rv3811	0.516	0.573
delta_Rv0954	0.185	0.937
PonA1	0.369	0.099
EccD1_KO	0.628	0.141
EspI_KO	0.408	-0.573
PE35_KO	-0.327	-0.265
PPE68_KO	0.067	-0.07
glycerol2	-0.342	-0.687
lignocerate	-0.704	-0.505
oleate	0.312	-0.43
phosphatidylcholine	-0.668	-0.562
acetate	-0.432	-0.073
glucAc	-0.641	-0.167
Rv0950ko	0.576	0.615
Rv1096ko	1.27	0.615
Rv3684ko	1.238	0.704
delta_otsA_trehalose	-0.21	-0.018