TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2532c/-:

update plot	correlation	link to info on gene
Rv0789c/-	(cc=0.6322)	info on Rv0789c/-
Rv1289/-	(cc=0.6041)	info on Rv1289/-
Rv0964c/-	(cc=0.6008)	info on Rv0964c/-
Rv3195/-	(cc=0.5664)	info on Rv3195/-
Rv2237A/-	(cc=0.5596)	info on Rv2237A/-
Rv1725c/-	(cc=0.5557)	info on Rv1725c/-
Rv0378/-	(cc=0.5433)	info on Rv0378/-
Rv2613c/-	(cc=0.5396)	info on Rv2613c/-
Rv2813/-	(cc=0.5383)	info on Rv2813/-
Rv2402/-	(cc=0.5381)	info on Rv2402/-

Correlation of Rv2532c/- with Rv2402/-

Normalized LFCs for Rv2532c/-:
(description and provenance of datasets)

	Rv2532c/-	Rv2402/-
Fe_supp_jason_reseq	0.077	0.208
low_pH_jason_reseq	-0.142	-0.125
NO_jason_reseq	-0.927	0.021
B6_jason_reseq	0.261	0.748
MHCII_jason_reseq	1.303	1.001
Isoniazid02	0.432	1.094
Rifampicin4	-1.313	0.125
Ethambutol3	-0.103	0.817
Meropenem3	-0.229	0.541
Vancomycin16	0.382	0.146
Rv2680_day32	-0.539	-0.218
H37Rv_KO_MarP	0.648	0.013
hypoxia_3wks	0.183	-0.518
hypoxia_6wks	0.975	-0.065
glycerol	0.208	0.61
cholesterol	-0.189	0.13
AJ	-0.252	0.763
Bibs02	-0.387	0.183
Bibs02c	0.799	0.582
BL6	-1.155	-0.175
BL6a	0.281	0.1
BXD01	-1.316	-0.618
BXD010	-0.35	-0.64
BXD011	-0.82	0.114
BXD03	-1.069	-0.307
BXD04	-0.068	-0.187
BXD05	-0.717	-0.639
BXD06	-1.0	-0.401
BXD07	-0.597	-0.527
BXD08	-0.882	0.02
BXD09	-0.771	-0.403
CAST	0.237	0.556
CCcont	-0.654	-0.601
DS01	-0.082	0.46
DS02	-0.679	-0.104
DS04	0.093	0.902
DS0c	-0.011	0.746
GP01	-1.7	0.153
GP02	-1.314	0.588
GP0c	-1.791	0.495
NOD	-0.343	0.679
NZO	-0.131	0.301
PWK	0.546	0.631
H37Rv_KO_CtpC	-0.008	-0.68
H37Rv_KO_CtpD	-1.919	-0.192
H37Rv_KO_Rv1272	-1.683	-0.231
H37Rv_KO_SugABC	-0.102	0.288
H37Rv_KO_MbtN	0.421	0.327
Trans05	-0.623	-0.577
macrophage_unactivated	-0.354	-0.341
IL1	0.81	-0.32
Rapamycin	-0.319	-0.178
Tcell	-1.196	-0.629
GMCSF	1.428	-0.026
IFNab	0.59	-0.484
IFNg	0.609	-0.208
IFNg_GMCSF1	0.327	-0.405
Rv1432_day32	0.232	-0.155
Rv1565c_day32	-0.305	-1.114
secA2_input	0.0	-0.626
delta_Rv3594	0.089	-0.303
delta_Rv3717	-0.015	-0.072
delta_Rv3811	-1.811	-0.476
delta_Rv0954	-1.61	0.048
PonA1	0.91	0.133
EccD1_KO	0.299	0.033
EspI_KO	-0.197	0.057
PE35_KO	0.446	-0.239
PPE68_KO	0.829	0.128
glycerol2	1.208	0.633
lignocerate	2.474	1.305
oleate	-0.784	0.06
phosphatidylcholine	2.22	0.878
acetate	3.405	1.48
glucAc	2.638	1.751
Rv0950ko	-0.588	-0.395
Rv1096ko	-1.043	-0.148
Rv3684ko	0.033	0.187
delta_otsA_trehalose	-0.965	-0.305