TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2532c/-:

update plot	correlation	link to info on gene
Rv0789c/-	(cc=0.6322)	info on Rv0789c/-
Rv1289/-	(cc=0.6041)	info on Rv1289/-
Rv0964c/-	(cc=0.6008)	info on Rv0964c/-
Rv3195/-	(cc=0.5664)	info on Rv3195/-
Rv2237A/-	(cc=0.5596)	info on Rv2237A/-
Rv1725c/-	(cc=0.5557)	info on Rv1725c/-
Rv0378/-	(cc=0.5433)	info on Rv0378/-
Rv2613c/-	(cc=0.5396)	info on Rv2613c/-
Rv2813/-	(cc=0.5383)	info on Rv2813/-
Rv2402/-	(cc=0.5381)	info on Rv2402/-

Correlation of Rv2532c/- with Rv1725c/-

Normalized LFCs for Rv2532c/-:
(description and provenance of datasets)

	Rv2532c/-	Rv1725c/-
Fe_supp_jason_reseq	0.077	-0.071
low_pH_jason_reseq	-0.142	-0.852
NO_jason_reseq	-0.927	0.333
B6_jason_reseq	0.261	-0.975
MHCII_jason_reseq	1.303	0.257
Isoniazid02	0.432	0.205
Rifampicin4	-1.313	0.265
Ethambutol3	-0.103	0.255
Meropenem3	-0.229	0.315
Vancomycin16	0.382	-0.085
Rv2680_day32	-0.539	0.205
H37Rv_KO_MarP	0.648	0.598
hypoxia_3wks	0.183	0.0
hypoxia_6wks	0.975	-0.136
glycerol	0.208	0.053
cholesterol	-0.189	-0.219
AJ	-0.252	0.513
Bibs02	-0.387	0.0
Bibs02c	0.799	-0.194
BL6	-1.155	0.439
BL6a	0.281	-0.277
BXD01	-1.316	-0.535
BXD010	-0.35	-0.478
BXD011	-0.82	-0.33
BXD03	-1.069	-0.407
BXD04	-0.068	-0.857
BXD05	-0.717	-0.532
BXD06	-1.0	-0.155
BXD07	-0.597	-0.332
BXD08	-0.882	0.1
BXD09	-0.771	-0.632
CAST	0.237	0.095
CCcont	-0.654	-0.114
DS01	-0.082	-0.387
DS02	-0.679	-1.068
DS04	0.093	0.284
DS0c	-0.011	-0.214
GP01	-1.7	0.065
GP02	-1.314	0.381
GP0c	-1.791	-0.418
NOD	-0.343	-0.739
NZO	-0.131	0.111
PWK	0.546	0.357
H37Rv_KO_CtpC	-0.008	0.601
H37Rv_KO_CtpD	-1.919	-1.686
H37Rv_KO_Rv1272	-1.683	0.895
H37Rv_KO_SugABC	-0.102	0.344
H37Rv_KO_MbtN	0.421	0.437
Trans05	-0.623	-0.106
macrophage_unactivated	-0.354	0.117
IL1	0.81	0.501
Rapamycin	-0.319	0.439
Tcell	-1.196	-0.485
GMCSF	1.428	0.618
IFNab	0.59	0.057
IFNg	0.609	0.267
IFNg_GMCSF1	0.327	0.531
Rv1432_day32	0.232	-0.675
Rv1565c_day32	-0.305	-0.128
secA2_input	0.0	0.152
delta_Rv3594	0.089	0.467
delta_Rv3717	-0.015	0.535
delta_Rv3811	-1.811	0.552
delta_Rv0954	-1.61	1.013
PonA1	0.91	-0.111
EccD1_KO	0.299	0.49
EspI_KO	-0.197	0.334
PE35_KO	0.446	0.0
PPE68_KO	0.829	0.163
glycerol2	1.208	1.223
lignocerate	2.474	1.836
oleate	-0.784	0.298
phosphatidylcholine	2.22	1.619
acetate	3.405	2.434
glucAc	2.638	2.05
Rv0950ko	-0.588	-0.235
Rv1096ko	-1.043	0.537
Rv3684ko	0.033	0.612
delta_otsA_trehalose	-0.965	-1.109