TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2303c/-:

update plot	correlation	link to info on gene
Rv2881c/cdsA	(cc=0.549)	info on Rv2881c/cdsA
Rv3184/-	(cc=0.5372)	info on Rv3184/-
Rv1673c/-	(cc=0.5317)	info on Rv1673c/-
Rv2576c/-	(cc=0.5087)	info on Rv2576c/-
Rv1215c/-	(cc=0.5001)	info on Rv1215c/-
Rv2278/-	(cc=0.4905)	info on Rv2278/-
Rv1369c/-	(cc=0.4873)	info on Rv1369c/-
Rv3533c/PPE62	(cc=0.4837)	info on Rv3533c/PPE62
Rv3884c/eccA2	(cc=0.4774)	info on Rv3884c/eccA2
Rv1756c/-	(cc=0.4652)	info on Rv1756c/-

Correlation of Rv2303c/- with Rv3884c/eccA2

Normalized LFCs for Rv2303c/-:
(description and provenance of datasets)

	Rv2303c/-	Rv3884c/eccA2
Fe_supp_jason_reseq	-0.186	-0.377
low_pH_jason_reseq	0.269	-0.718
NO_jason_reseq	0.0	-0.845
B6_jason_reseq	0.047	0.201
MHCII_jason_reseq	0.088	0.406
Isoniazid02	0.111	-0.818
Rifampicin4	-0.195	-0.095
Ethambutol3	0.507	1.608
Meropenem3	0.864	-0.131
Vancomycin16	0.0	-0.39
Rv2680_day32	0.163	0.152
H37Rv_KO_MarP	0.134	0.222
hypoxia_3wks	0.439	0.0
hypoxia_6wks	0.23	-0.409
glycerol	0.452	0.601
cholesterol	0.196	0.315
AJ	0.355	0.845
Bibs02	-0.176	0.18
Bibs02c	-0.056	0.374
BL6	0.37	0.136
BL6a	0.076	0.373
BXD01	0.184	0.354
BXD010	0.136	0.241
BXD011	0.401	0.401
BXD03	-0.036	0.367
BXD04	0.896	0.845
BXD05	0.786	1.05
BXD06	0.447	0.581
BXD07	0.476	0.207
BXD08	0.101	-0.128
BXD09	0.215	0.292
CAST	0.245	0.434
CCcont	0.019	0.507
DS01	0.121	0.33
DS02	-0.306	0.0
DS04	0.394	0.347
DS0c	0.014	0.121
GP01	0.242	0.118
GP02	0.977	0.756
GP0c	0.067	-0.263
NOD	0.74	0.402
NZO	0.977	0.09
PWK	0.429	0.313
H37Rv_KO_CtpC	0.768	0.707
H37Rv_KO_CtpD	0.523	-0.06
H37Rv_KO_Rv1272	0.563	0.016
H37Rv_KO_SugABC	0.293	1.163
H37Rv_KO_MbtN	0.825	0.184
Trans05	0.981	0.308
macrophage_unactivated	-0.638	-0.514
IL1	-0.839	-0.89
Rapamycin	0.114	-1.221
Tcell	0.391	-0.349
GMCSF	-0.401	-0.137
IFNab	-0.587	-0.907
IFNg	-0.596	-0.553
IFNg_GMCSF1	-0.544	-1.471
Rv1432_day32	0.27	-1.159
Rv1565c_day32	-0.178	-0.319
secA2_input	-0.088	-0.409
delta_Rv3594	0.543	-0.563
delta_Rv3717	-0.115	-0.191
delta_Rv3811	-0.497	0.088
delta_Rv0954	-0.512	-0.048
PonA1	0.495	0.209
EccD1_KO	1.243	0.398
EspI_KO	0.924	0.163
PE35_KO	0.613	0.627
PPE68_KO	0.56	0.554
glycerol2	-0.167	0.343
lignocerate	-0.46	0.058
oleate	-0.139	0.164
phosphatidylcholine	-0.38	0.179
acetate	-0.08	-0.233
glucAc	-0.328	0.295
Rv0950ko	0.066	0.0
Rv1096ko	-0.718	-0.434
Rv3684ko	0.026	-0.848
delta_otsA_trehalose	0.098	-0.485