TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2303c/-:

update plot	correlation	link to info on gene
Rv2881c/cdsA	(cc=0.549)	info on Rv2881c/cdsA
Rv3184/-	(cc=0.5372)	info on Rv3184/-
Rv1673c/-	(cc=0.5317)	info on Rv1673c/-
Rv2576c/-	(cc=0.5087)	info on Rv2576c/-
Rv1215c/-	(cc=0.5001)	info on Rv1215c/-
Rv2278/-	(cc=0.4905)	info on Rv2278/-
Rv1369c/-	(cc=0.4873)	info on Rv1369c/-
Rv3533c/PPE62	(cc=0.4837)	info on Rv3533c/PPE62
Rv3884c/eccA2	(cc=0.4774)	info on Rv3884c/eccA2
Rv1756c/-	(cc=0.4652)	info on Rv1756c/-

Correlation of Rv2303c/- with Rv3184/-

Normalized LFCs for Rv2303c/-:
(description and provenance of datasets)

	Rv2303c/-	Rv3184/-
Fe_supp_jason_reseq	-0.186	-0.835
low_pH_jason_reseq	0.269	0.739
NO_jason_reseq	0.0	-0.585
B6_jason_reseq	0.047	-0.225
MHCII_jason_reseq	0.088	-0.662
Isoniazid02	0.111	-0.423
Rifampicin4	-0.195	-0.07
Ethambutol3	0.507	0.783
Meropenem3	0.864	-0.738
Vancomycin16	0.0	-0.358
Rv2680_day32	0.163	-0.136
H37Rv_KO_MarP	0.134	-0.392
hypoxia_3wks	0.439	0.251
hypoxia_6wks	0.23	-0.161
glycerol	0.452	-0.576
cholesterol	0.196	0.054
AJ	0.355	1.316
Bibs02	-0.176	0.302
Bibs02c	-0.056	0.758
BL6	0.37	-0.357
BL6a	0.076	0.143
BXD01	0.184	0.56
BXD010	0.136	0.159
BXD011	0.401	0.076
BXD03	-0.036	0.228
BXD04	0.896	0.111
BXD05	0.786	0.524
BXD06	0.447	0.114
BXD07	0.476	0.273
BXD08	0.101	0.131
BXD09	0.215	0.065
CAST	0.245	0.651
CCcont	0.019	-0.354
DS01	0.121	0.59
DS02	-0.306	0.816
DS04	0.394	0.548
DS0c	0.014	0.742
GP01	0.242	1.005
GP02	0.977	1.225
GP0c	0.067	0.423
NOD	0.74	0.451
NZO	0.977	0.826
PWK	0.429	1.161
H37Rv_KO_CtpC	0.768	0.652
H37Rv_KO_CtpD	0.523	0.125
H37Rv_KO_Rv1272	0.563	-0.034
H37Rv_KO_SugABC	0.293	0.68
H37Rv_KO_MbtN	0.825	1.069
Trans05	0.981	0.374
macrophage_unactivated	-0.638	0.025
IL1	-0.839	-1.848
Rapamycin	0.114	-1.636
Tcell	0.391	-1.395
GMCSF	-0.401	-1.436
IFNab	-0.587	-2.029
IFNg	-0.596	-1.253
IFNg_GMCSF1	-0.544	-0.776
Rv1432_day32	0.27	1.485
Rv1565c_day32	-0.178	-0.695
secA2_input	-0.088	-0.416
delta_Rv3594	0.543	0.321
delta_Rv3717	-0.115	-0.36
delta_Rv3811	-0.497	-0.464
delta_Rv0954	-0.512	0.279
PonA1	0.495	-0.461
EccD1_KO	1.243	1.358
EspI_KO	0.924	1.999
PE35_KO	0.613	1.45
PPE68_KO	0.56	0.483
glycerol2	-0.167	-0.324
lignocerate	-0.46	-0.773
oleate	-0.139	-0.359
phosphatidylcholine	-0.38	-0.438
acetate	-0.08	-0.083
glucAc	-0.328	0.883
Rv0950ko	0.066	-0.103
Rv1096ko	-0.718	0.199
Rv3684ko	0.026	0.046
delta_otsA_trehalose	0.098	-0.443