TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2269c/-:

update plot	correlation	link to info on gene
Rv2884/-	(cc=0.4365)	info on Rv2884/-
Rv2436/rbsK	(cc=0.409)	info on Rv2436/rbsK
Rv2674/msrB	(cc=0.4039)	info on Rv2674/msrB
Rv1615/-	(cc=0.396)	info on Rv1615/-
Rv2810c/-	(cc=0.3942)	info on Rv2810c/-
Rv2274A/mazE8	(cc=0.3838)	info on Rv2274A/mazE8
Rv0798c/cfp29	(cc=0.3705)	info on Rv0798c/cfp29
Rv2840c/-	(cc=0.3691)	info on Rv2840c/-
Rv1574/-	(cc=0.3683)	info on Rv1574/-
Rv1598c/-	(cc=0.3604)	info on Rv1598c/-

Correlation of Rv2269c/- with Rv2274A/mazE8

Normalized LFCs for Rv2269c/-:
(description and provenance of datasets)

	Rv2269c/-	Rv2274A/mazE8
Fe_supp_jason_reseq	-0.999	-1.073
low_pH_jason_reseq	0.766	0.408
NO_jason_reseq	-0.373	0.457
B6_jason_reseq	-0.527	-0.58
MHCII_jason_reseq	-0.244	-0.18
Isoniazid02	0.038	0.377
Rifampicin4	1.194	1.083
Ethambutol3	-0.308	0.043
Meropenem3	0.09	0.238
Vancomycin16	0.326	0.581
Rv2680_day32	1.417	0.359
H37Rv_KO_MarP	0.116	0.26
hypoxia_3wks	0.63	-0.048
hypoxia_6wks	-1.109	0.048
glycerol	1.2	-1.419
cholesterol	0.55	-1.219
AJ	-0.156	0.382
Bibs02	0.403	2.072
Bibs02c	-0.497	-2.099
BL6	0.788	0.275
BL6a	-0.595	0.765
BXD01	0.648	1.466
BXD010	-1.06	0.109
BXD011	-0.694	1.765
BXD03	0.645	0.769
BXD04	0.222	0.811
BXD05	-0.697	1.881
BXD06	0.258	0.952
BXD07	0.444	1.15
BXD08	0.459	2.183
BXD09	0.111	1.695
CAST	0.567	-1.246
CCcont	0.633	0.729
DS01	0.221	1.018
DS02	0.329	1.827
DS04	1.883	1.668
DS0c	0.448	0.591
GP01	-0.653	-0.935
GP02	-0.409	-1.187
GP0c	0.686	-0.61
NOD	0.747	-0.903
NZO	-0.316	0.543
PWK	-1.124	-2.342
H37Rv_KO_CtpC	0.461	1.727
H37Rv_KO_CtpD	-1.755	0.769
H37Rv_KO_Rv1272	1.378	2.315
H37Rv_KO_SugABC	0.376	3.786
H37Rv_KO_MbtN	1.539	2.954
Trans05	2.132	1.811
macrophage_unactivated	0.439	1.398
IL1	-0.819	1.353
Rapamycin	0.249	2.157
Tcell	0.635	1.743
GMCSF	0.969	1.888
IFNab	0.245	0.426
IFNg	-0.946	0.997
IFNg_GMCSF1	1.153	-0.556
Rv1432_day32	1.014	-0.426
Rv1565c_day32	-0.747	-0.382
secA2_input	-0.853	-1.035
delta_Rv3594	-0.477	-1.263
delta_Rv3717	-1.037	-1.195
delta_Rv3811	-1.41	-1.88
delta_Rv0954	-0.36	-1.616
PonA1	-0.563	-1.255
EccD1_KO	-0.069	1.756
EspI_KO	1.46	0.228
PE35_KO	0.939	0.563
PPE68_KO	1.241	1.126
glycerol2	0.675	-0.076
lignocerate	0.469	-0.359
oleate	0.308	-0.227
phosphatidylcholine	0.648	0.426
acetate	-0.066	-0.474
glucAc	-0.488	-0.524
Rv0950ko	-0.573	-0.1
Rv1096ko	-0.305	0.253
Rv3684ko	0.596	0.409
delta_otsA_trehalose	-0.247	-1.615