TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2269c/-:

update plot	correlation	link to info on gene
Rv2884/-	(cc=0.4365)	info on Rv2884/-
Rv2436/rbsK	(cc=0.409)	info on Rv2436/rbsK
Rv2674/msrB	(cc=0.4039)	info on Rv2674/msrB
Rv1615/-	(cc=0.396)	info on Rv1615/-
Rv2810c/-	(cc=0.3942)	info on Rv2810c/-
Rv2274A/mazE8	(cc=0.3838)	info on Rv2274A/mazE8
Rv0798c/cfp29	(cc=0.3705)	info on Rv0798c/cfp29
Rv2840c/-	(cc=0.3691)	info on Rv2840c/-
Rv1574/-	(cc=0.3683)	info on Rv1574/-
Rv1598c/-	(cc=0.3604)	info on Rv1598c/-

Correlation of Rv2269c/- with Rv1574/-

Normalized LFCs for Rv2269c/-:
(description and provenance of datasets)

	Rv2269c/-	Rv1574/-
Fe_supp_jason_reseq	-0.999	1.146
low_pH_jason_reseq	0.766	0.785
NO_jason_reseq	-0.373	-0.465
B6_jason_reseq	-0.527	1.2
MHCII_jason_reseq	-0.244	0.378
Isoniazid02	0.038	0.351
Rifampicin4	1.194	0.341
Ethambutol3	-0.308	0.293
Meropenem3	0.09	3.363
Vancomycin16	0.326	0.639
Rv2680_day32	1.417	-1.997
H37Rv_KO_MarP	0.116	-2.994
hypoxia_3wks	0.63	0.0
hypoxia_6wks	-1.109	0.77
glycerol	1.2	-1.024
cholesterol	0.55	-0.475
AJ	-0.156	1.585
Bibs02	0.403	0.725
Bibs02c	-0.497	-0.467
BL6	0.788	2.01
BL6a	-0.595	0.227
BXD01	0.648	1.367
BXD010	-1.06	1.662
BXD011	-0.694	-0.418
BXD03	0.645	0.249
BXD04	0.222	2.507
BXD05	-0.697	-0.369
BXD06	0.258	0.765
BXD07	0.444	0.728
BXD08	0.459	1.454
BXD09	0.111	0.109
CAST	0.567	0.913
CCcont	0.633	1.886
DS01	0.221	0.092
DS02	0.329	1.297
DS04	1.883	0.357
DS0c	0.448	-1.248
GP01	-0.653	-0.986
GP02	-0.409	-0.831
GP0c	0.686	-1.299
NOD	0.747	0.257
NZO	-0.316	-1.011
PWK	-1.124	-0.644
H37Rv_KO_CtpC	0.461	-1.623
H37Rv_KO_CtpD	-1.755	-0.729
H37Rv_KO_Rv1272	1.378	1.674
H37Rv_KO_SugABC	0.376	-0.89
H37Rv_KO_MbtN	1.539	0.38
Trans05	2.132	0.718
macrophage_unactivated	0.439	1.174
IL1	-0.819	1.198
Rapamycin	0.249	1.142
Tcell	0.635	0.398
GMCSF	0.969	1.312
IFNab	0.245	1.318
IFNg	-0.946	-0.355
IFNg_GMCSF1	1.153	2.181
Rv1432_day32	1.014	0.18
Rv1565c_day32	-0.747	-3.216
secA2_input	-0.853	-4.156
delta_Rv3594	-0.477	-2.169
delta_Rv3717	-1.037	-4.501
delta_Rv3811	-1.41	-4.497
delta_Rv0954	-0.36	-2.702
PonA1	-0.563	-2.581
EccD1_KO	-0.069	0.881
EspI_KO	1.46	1.477
PE35_KO	0.939	1.832
PPE68_KO	1.241	2.4
glycerol2	0.675	2.221
lignocerate	0.469	2.297
oleate	0.308	-1.704
phosphatidylcholine	0.648	2.004
acetate	-0.066	3.401
glucAc	-0.488	2.883
Rv0950ko	-0.573	-0.392
Rv1096ko	-0.305	-1.405
Rv3684ko	0.596	1.398
delta_otsA_trehalose	-0.247	0.0